当人体内神经元受损时，RNA片段会产生可帮助修复损伤的蛋白质。但在患有"渐冻症"和脊髓性肌 萎缩症等神经系统疾病，以及脊髓在遭受损伤时，把完成修复工作所必须的RNA转移到细胞内受伤部 位的机制是失效的。 换句话说，RNA分子"迷路了"。它们无法到达需要的地方，这时损伤就成了永久性的。 但现在，美国斯坦福大学研究人员开发出一种"基因魔剪"（CRISPR）新技术，可将RNA运输到神 经元内特定位置，在那里它可以"重整旗鼓"，修复甚至再生细胞的部分区域。这项工作得到了美国国立 卫生研究院的支持，为被称为空间RNA医学的新型疗法奠定了基础。 这也意味着，凭借空间RNA医学提供的体内"邮政编码"，能实现"按图索骥"治疗神经系统疾病和创 伤性损伤。 CRISPR变身"邮递员" 你也许没有想到，人体中最长的细胞就是神经元——单个神经元可能超过1米长，而衰老、受伤和 突变都会破坏它在如此长的距离内运输微小RNA的能力。 近年来，研究人员逐渐意识到，RNA在细胞内的分布（即特定分子所在的位置），可能与其功能 同样重要。因此人们要实现治疗的目的，不仅需要了解RNA在细胞内部的重要工作，还要在需要的位 置，精准定向放置RNA。 " ...

7月23日，国新办新闻发布会释放重磅消息：海南自贸港封关定于2025年12月18日正式启动。 全岛封关运作是海南自贸港建设的标志性工程，也是进一步扩大开放的重要举措。封关后对企业和人员往 来有何影响？有哪些新的税收政策？如何进一步推动海南自贸港高水平对外开放？围绕这些市场关切问 题，证券时报记者采访了海南省开放型经济研究会会长李世杰、安永华南区主管合伙人黄寅。 证券时报记者：如何看待海南自贸港建设以来的开放举措？ 黄寅： 海南自贸港开放政策聚焦系统性制度创新与多层次产业布局，正加速吸引全球资本与产业链集聚， 形成"政策红利—产业升级—投资虹吸"的良性循环。 证券时报记者：封关日期的确定，会给海南自贸港的建设带来哪些影响？ 李世杰： 海南在发展深海科技方面很有优势，但这并不意味着要把深海科技领域的所有环节都放在海南， 海南最有优势的地方在深海探测，因此只需要把组装和测试的环节放在本地发展即可。再比如卫星发射方 面，和甘肃酒泉相比，海南文昌更适合发射重载火箭，因为这里离赤道近，可节省发射燃料，同时航运也 更适合运输重载火箭。综合起来，海南并不适合发展产业链特别长的产业，但可以因地制宜地壮大深海科 技、生物医药等高 ...

Group 1 - The Shaanxi Provincial Science and Technology Department has released the second batch of capability lists for concept verification centers and pilot test bases to enhance the efficiency of open sharing services and apply technological innovation results to specific industries and industrial chains [1][2] - Five provincial concept verification centers, including the Shaanxi Provincial Defense Technology (Radar) Concept Verification Center, aim to improve the maturity of technological achievements through principle verification, technical feasibility verification, and commercial feasibility verification [1] - Eleven pilot test bases, such as the Shaanxi High-Strength Lightweight Aluminum Alloy Materials Pilot Test Base, focus on providing intermediate testing services for technology achievement maturation and production process development to facilitate the engineering, productization, and industrialization of technological results [1] Group 2 - The provincial government plans to cultivate and recognize 60 concept verification centers and pilot test bases by the end of 2026, aiming to conduct 500 concept verifications and 500 pilot maturation services, leading to the launch of 300 new products and the incubation of 200 technology-based enterprises [2] - This initiative is designed to accelerate the transformation of technological achievements, upgrade traditional industries, foster emerging industries, and lay the groundwork for future industries with a unique Shaanxi model [2]

宏观热点 7月23日，海关总署制定了《中华人民共和国海关对海南自由贸易港监管办法》，现予发布。海关依照 本办法对下列对象实施监督管理：（一）海南自贸港与中华人民共和国关境外其他国家和地区（以下简 称境外）之间进出的交通运输工具、货物集装箱等运输设备、人员、货物、物品；（二）自海南自贸港 进入中华人民共和国关境内其他地区的"零关税"货物及其加工制成品、享受加工增值免关税政策的保税 货物、自境外进入海南自贸港时放宽贸易管理措施货物及其加工制成品；（三）海南自贸港内尚未办结 海关手续的货物。 科技部发布《驾驶自动化技术研发伦理指引》 7月23日，科技部官网公布《驾驶自动化技术研发伦理指引》，意在防范技术研发与产品应用过程中的 科技伦理风险，推动该领域健康发展。 这份由国家科技伦理委员会人工智能伦理分委员会组织编写的文件，遵循以人为本、增进福祉，安全优 先、尊重生命，公平公正、避免偏见，知情保障、信息公开的基本原则。其中特别强调，在面对不可避 免的交通事故或极端行车环境时，应确保驾驶自动化系统能高度尊重生命，积极寻求有效应对方法最大 限度降低对人的伤害；与驾驶自动化技术相关的算法、模型等内容应当被清晰记录、随时可查。 ...

Core Insights - The Jiangsu Provincial Strategic Emerging Industry Fund has become a benchmark for capital layout in strategic emerging industries nationwide after one year of operation [1] - The fund aims to support technological innovation and industrial upgrading, providing tangible benefits to many enterprises [1] - Future strategies include enhancing mechanisms to better cultivate local innovation ecosystems while continuing to play a guiding role [1] Group 1: Investment Strategy - The Jiangsu Huanghai Financial Holdings Group is actively planning its first direct investment project in the green low-carbon sector, indicating a clear focus on strategic emerging industries [1] - The Suzhou AI industry has developed into a trillion-level industry, with over 2,000 AI companies, showcasing the city's commitment to this sector [1] - Selecting potential enterprises requires high professional insight and industry judgment due to the increasing difficulty in accurately assessing emerging technologies [1][2] Group 2: Fund Operations and Support - Companies receiving fund support express a desire for more precise and comprehensive assistance, particularly in market expansion and resource connections [3][4] - There is a call for more diverse special funds to accompany enterprises through various financing cycles, emphasizing the need for tailored support [4] - Fund management faces challenges in cross-regional resource coordination and must optimize resource allocation and service response speed [4] Group 3: Long-term Vision and Ecosystem Development - The fund emphasizes a "long-termism" approach, focusing on nurturing a healthy industrial innovation ecosystem [5] - The fund aims to guide capital towards strategic areas and weak links, willing to bear necessary risks to support innovation [5] - Future plans include enhancing investment strategies by building industry maps with leading enterprises to improve early project selection accuracy [6] Group 4: Fund Cluster Effect - The revised management measures for the Jiangsu Provincial Strategic Emerging Industry Fund encourage collaboration with state-owned enterprises and international investment institutions to attract quality capital [7] - The signing of a 10 billion yuan fund indicates the integration of central enterprise resources into Jiangsu's industrial layout [7] - The fund cluster is expected to significantly contribute to the development of emerging industry ecosystems in Jiangsu [7]

1）主动公募基金港股持仓占比从去年底的25.8%提升至32.5%，当前此类基金总规模约1.55万亿港元，年初至今港股配置提升规模约1,000-1,200亿港元。 不过考虑到其中存在指数价格因素后（平均涨幅15%左右），年内此类基金港股净增量约850-1,050亿港元 ， 贡献年初以来南向约8,000亿港元流入的10- 15%左右； 2）公募整体港股持仓占比从去年底的30.5%提升至目前39.8%左右，此类基金总规模约2.62万亿港元，年初至今港股配置提升规模约2,500-3,000亿港元， 同样考虑价格因素，年初至今港股净增量约2,200-2,800亿港元。排除主动公募约900亿港元， 此类（ETF为主）基金港股净增量约1,500-2,000亿港元，贡 献南向的25-30%； 3) 余下约50%的部分相对难以拆解，其中保险部分更多是稳步买入分红尤其是银行， 我们也看到年初以来港股银行板块AH溢价已经低于理论上125% 的"隐形底"（贡献约25-35%）；而另外15-20%的部分则属于直接开通港股通交易的个人投资者与私募基金等。 结合公募基金最新披露的二季报，我们更 新公募基金的港股持仓和配置变化，以此提供更多 ...

Group 1 - The 2025 Fortune China 500 list ranks State Grid Corporation at the top with a revenue of $548.41 billion, followed by China National Petroleum and China Petroleum & Chemical with revenues of $412.65 billion and $407.49 billion respectively [1][2] - Hubei province has 9 companies on the list, maintaining the same number as in 2024, with a total revenue of $147.01 billion, an increase of $15.38 billion or 11.69% year-on-year [1][3] Group 2 - The 9 companies from Hubei include Dongfeng Motor Group ($51.31 billion, rank 73), Zall Smart ($22.57 billion, rank 160), Hubei Lian Investment Group ($21.10 billion, rank 164), and others, with 5 companies showing improved rankings [2][3] - Hubei Lian Investment is the only new entrant this year, while Tianmao Group dropped off the list. Five companies improved their rankings significantly, with Zall Smart rising 22 places and Wenta Technology rising 46 places [3][4] Group 3 - The revenue threshold for the 2025 list is approximately $3.62 billion, a decrease of about 3% from 2024 [4] - The total revenue of the 500 companies on the list is about $14.2 trillion, a decrease of approximately 2.7% from the previous year, while net profit increased by about 7% to $756.4 billion [3][4] Group 4 - Dongfeng Motor is focusing on new energy and intelligent connected vehicles, aiming for rapid revenue growth and improved profitability [5][6] - YF Communication is expanding into strategic emerging industries like network security and AI, achieving breakthroughs in radiation-resistant fiber optic cables [5][6] - Hubei Lian Investment is enhancing its core competitiveness through innovation in fine chemicals, new materials, and new energy, reporting significant revenue and profit growth in the first half of 2025 [6][7] - Jiuzhoutong is transforming its development strategy to enhance its position as a leading pharmaceutical distributor, emphasizing legal and risk management for sustainable growth [7] - Huaxin Cement is a major supplier for large hydropower projects, having supplied over 2 million tons of cement, showcasing its high-quality products in significant infrastructure projects [7]

炒股就看金麒麟分析师研报，权威，专业，及时，全面，助您挖掘潜力主题机会！ IPO雷达|九年估值升45倍，麦济生物赴港上市胜算几何？ 日前，湖南麦济生物技术股份有限公司（下称"麦济生物"）向港交所主板递交上市申请，中金公司担任独家保荐人。这 家成立于2016年的创新生物药企由张成海博士及其外甥女李敏共同创立，目前仅有43名员工。八年间，公司围绕过敏性 及自身免疫疾病打造出8款抗体候选药管线，其中核心产品MG-K10已推进至注册性III期临床。 然而截至2024年底，麦济生物尚无自主产品收入，过去两年累计研发投入达3.16亿元人民币，经营亏损居高不下（招股 书）。在持续"烧钱"背景下，公司估值却通过多轮融资攀升至约26.4亿元人民币。麦济生物旗下产品押注"长效抗体"这 一热门赛道，MG-K10作为长效抗IL-4Rα单抗，瞄准全球过敏疾病用药市场。 麦济生物能否通过本次募资熬过关键临床验证期，并凭借长效抗体的差异化优势实现商业化突围？这一悬念考验着投资 人对于"烧钱换未来"模式的信心。 估值持续提高 2016年至今，麦济生物历经多轮股权融资，估值曲线陡升但资金始终紧平衡。据统计，公司成立以来合计融资超过7亿 元人民 ...

药明生物：预计上半年净利润同比增长56% 金十数据7月24日讯，药明生物(02269.HK)港交所公告，预期上半年本公司收益将增长约16%；毛利率 将同比提升约3.6%；本公司截至二零二五年六月三十日止六个月的利润及归属于本公司权益股东的利 润相比于去年同期将分别增长约54%和约56%。 ...

智通财经7月24日电，药明生物在港交所公告，预期与去年同期比较上半年收益增长约16%；上半年利 润及归属于公司权益股东的利润相比于去年同期将分别增长约54%和约56%。 ...