Core Viewpoint - The article highlights the significant advancements in mass spectrometry products developed by domestic companies in China, supported by national policies, showcasing a trend towards self-innovation and technological breakthroughs in the industry [1][5]. Policy Support and Development - Since the issuance of the "Opinions on Promoting the Demonstration Application of First Sets of Major Technical Equipment" in April 2018, various provinces have released recognition lists, providing policy support and financial rewards amounting to millions, which has greatly stimulated corporate innovation [3]. - The introduction of the "Management Measures for the Detection and Evaluation of China's First Sets of Major Technical Equipment (Trial)" in 2024 clarifies the definition, scope, evaluation criteria, and procedures for first sets, promoting equipment quality improvement and industrial upgrading [4]. Technological Breakthroughs - The article compiles a list of major technological breakthroughs in the mass spectrometry field, detailing various first sets of equipment recognized in 2023, indicating a growing trend of domestic innovation [5][6]. - Mass spectrometry products are becoming a focal point in the scientific instrument sector, with advancements ranging from single-cell metabolomics analysis to rapid microbial identification, showcasing the transition of domestic mass spectrometers from "capable of being produced" to "reliable and usable" [25]. Equipment and Performance - Specific examples of first sets of major technical equipment include: - Single-cell metabolomics analysis mass spectrometer SinCell-100 developed by Ningbo Huayi Ningchuang Intelligent Technology Co., Ltd. [7] - Multi-channel RF-enhanced proton transfer reaction time-of-flight mass spectrometer developed by Hangzhou Puyu Technology Development Co., Ltd. [11] - Fully automated microbial mass spectrometry detection system by Chongqing Zhongyuan Huiji Biotechnology Co., Ltd. [12] - Triple quadrupole inductively coupled plasma mass spectrometer LabMS 5000 ICP-MS/MS by Beijing Leibotai Technology Co., Ltd. [14] Industry Outlook - The significance of the first set of equipment extends beyond being a mere label; it represents a critical step for domestic equipment to transition from production capability to trusted usability. With the continuous improvement of the first set policy system and the transparency of detection and evaluation mechanisms, the Chinese mass spectrometry industry is poised to move from "breakthrough" to "rise" [25].