Core Insights - The 2025 Top 50 Bed Bug Cities List by Orkin reveals significant shifts in bed bug activity, with Hartford, Connecticut making the largest leap, rising 48 spots to No. 35, indicating a notable increase in infestations [1][2] - Chicago remains the most bed bug-infested city for the fifth consecutive year, while cities like Charlotte, Philadelphia, and New York have seen significant drops in their rankings, suggesting improved control measures [1][4] Summary by Category Bed Bug Activity - Hartford, Connecticut jumped 48 spots to No. 35, indicating a significant rise in bed bug activity [1] - Chicago continues to hold the top position as the most infested city [1] - Charlotte, Philadelphia, and New York experienced significant drops in their rankings, suggesting fewer reported infestations [1][4] Treatment Data - The rankings are based on treatment data from May 15, 2024, to May 14, 2025, covering both residential and commercial bed bug treatments [2] - The list reflects the metro areas where Orkin performed the most bed bug treatments during this period [2] Prevention and Control - Orkin emphasizes the importance of early detection and proactive prevention due to bed bugs' growing resistance to certain treatments [7] - Travelers are advised to inspect hotel rooms and luggage to prevent bringing bed bugs home, with specific tips provided under the acronym S.L.E.E.P. [5][6] - Orkin offers training for hospitality teams and strategic responses to bed bug infestations [7]