Breast Cancer Index (BCI) Test
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Hologic's BCI Test Shows Growing Impact in Endocrine Therapy Decisions
ZACKS· 2025-12-04 16:26
Core Insights - Hologic's acquisition of Biotheranostics in 2021 has significantly enhanced its position in the oncology sector, which is characterized by rapid growth and higher profit margins compared to its traditional service offerings [2] - The Breast Cancer Index (BCI) test, developed by Biotheranostics, is the only test endorsed by major clinical guidelines for predicting the benefits of extended endocrine therapy in early-stage, HR+ breast cancer patients, although it has not received FDA approval [2] - Hologic and Biotheranostics will present 11 studies at the 2025 San Antonio Breast Cancer Symposium, focusing on the BCI test's expanded utility and consistent performance across various patient demographics [3] Business Performance - Biotheranostics has contributed positively to Hologic's Molecular Diagnostics business, with ongoing growth driven by increased adoption and coverage of the BCI test [5] - An analysis presented at the 2025 American Society of Clinical Oncology Annual Meeting indicated that BCI testing altered treatment recommendations in approximately 40% of cases among over 2,800 patients, enhancing physician confidence and patient comfort regarding treatment decisions [4] Competitive Landscape - Medtronic has received FDA clearance for its Hugo robotic-assisted surgery system, expanding options for urologic surgical procedures [6] - Becton, Dickinson and Company has launched new cell analyzers with advanced imaging technologies, facilitating research in immunology and cancer therapy [7] Stock Performance and Valuation - Hologic's stock has increased by 18.9% over the past six months, outperforming the industry average growth of 14% [8] - The company is currently trading at a forward five-year price-to-sales ratio of 3.87X, which is lower than the industry average of 4.39X [10] Earnings Projections - Analysts project Hologic's earnings for fiscal years 2025 and 2026 to be $4.50 and $4.96 per share, respectively, with current quarter estimates at $1.09 [12]