Core Insights - The study published in The Lancet Respiratory Medicine indicates a significant rise in obstructive sleep apnea (OSA) in the U.S. over the next three decades, driven by factors such as an aging population and increasing body mass index (BMI) [1][2][3] Group 1: Prevalence Estimates - By 2050, OSA is projected to affect nearly 77 million U.S. adults, a relative increase of nearly 35% from 2020, impacting 46% of adults aged 30-69 [2] - A 65% relative increase in OSA prevalence among women is expected, reaching 30.4 million cases by 2050, highlighting the need for greater awareness of OSA symptoms in women [6] - A 19% relative increase in OSA prevalence among men is anticipated, reaching 45.9 million cases by 2050, indicating ongoing risks in aging male populations [6] Group 2: Health Implications - OSA is linked to serious health issues, including hypertension, cardiovascular disease, diabetes, and stroke, with over 80% of cases remaining undiagnosed and untreated [3] - The study emphasizes the urgent need for earlier diagnosis, preventative strategies, and healthcare resource allocation to address OSA as a major public health concern [3][5] Group 3: Industry Response - The research calls for expanded screening, increased awareness of symptoms, and improved access to testing and treatment, particularly in home settings [4][5] - The anticipated impact of GLP-1 therapies on future OSA prevalence is limited, with reductions estimated at under 5%, indicating that obesity is just one of many contributing factors to OSA [6] - The study serves as a data-driven forecast to help health systems, payers, and policymakers prepare for the growing prevalence of OSA and improve long-term patient outcomes [5][6]