TABLE OF CONTENTS As filed with the Securities and Exchange Commission on June 16, 2025. Registration No. 333-287551 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 2 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 CARIS LIFE SCIENCES, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Texas 8071 85-2077369 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer ...

Amendment No. 1 TABLE OF CONTENTS As filed with the Securities and Exchange Commission on June 9, 2025. Registration No. 333-287551 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 CARIS LIFE SCIENCES, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Texas 8071 85-2077369 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer ...

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on May 23, 2025. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 CARIS LIFE SCIENCES, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Texas 8071 85-2077369 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identification Number) 75 ...