Core Insights - GoDaddy's analysis reveals the Most Entrepreneurial Cities of 2025, highlighting both small and large cities as key drivers of innovation in the U.S. [1][2][6] Summary by Category Entrepreneurial Rankings - The ranking is based on the number of new ventures created in the previous calendar year, showcasing cities that have emerged as entrepreneurial hotspots [2][3]. - The top 10 cities include San Francisco, Los Angeles, Denver, Oklahoma City, Frankfort, Ontario, Wilmington (DE), Wilmington (NC), Katy, and Alameda [4]. City Highlights - San Francisco leads with 173,054 new businesses, reflecting its strong tech culture and access to venture capital [4][7]. - Smaller suburban cities like Frankfort, Ontario, Katy, and Alameda have emerged as significant entrepreneurial centers, challenging traditional urban business hubs [7]. - Wilmington is noted for having two cities in the top 10, indicating a growing trend for small businesses in areas with the same name [7]. California's Role - California is identified as a new epicenter for small businesses, with four cities in the top 10, despite its high cost of living [7]. Research Methodology - The GoDaddy Small Business Research Lab analyzes over 20 million online businesses, focusing on microbusinesses that employ fewer than ten people [8].