Shares of Guardant Health Inc. (GH) are up over 25% at $90 in premarket trading on Thursday, after the company reported exceptionally strong financial results for the quarter ended September 30, 2025, and raised its full-year 2025 outlook.This commercial-stage precision oncology company Guardant360 Liquid test and Guardant360 CDx test, the first comprehensive liquid biopsy test approved by the FDA to provide tumor mutation profiling with solid tumors and to be used as a companion diagnostic in connection w ...

Company Overview - Tempus AI, Inc. has launched xM for treatment response monitoring (TRM), a liquid biopsy assay aimed at detecting molecular responses to immune-checkpoint inhibitor (ICI) therapy in advanced solid tumors, enhancing its portfolio of assays for monitoring molecular response and minimal residual disease (MRD) [1][7] - The xM for TRM utilizes a multi-parametric algorithm to assess changes in circulating tumor DNA (ctDNA) from blood samples, allowing for early molecular response evaluation in patients undergoing ICI therapies [3][7] Industry Insights - The increasing incidence of various cancers, including lung, breast, bladder, and cervical cancers, has led to a growing adoption of immune checkpoint inhibitor therapies, which are projected to drive the global immune checkpoint inhibitors market to $154.25 billion by 2030, with a CAGR of 17.9% from 2024 to 2030 [2] - Competitors in the industry, such as Exact Sciences and Guardant Health, are also advancing their product offerings, with Exact Sciences launching new tests for colon cancer screening and molecular residual disease monitoring, while Guardant Health has enhanced its liquid biopsy tests with new applications and comprehensive biomarker testing [4][5] Financial Performance - Tempus AI's stock has seen a significant increase of 91% year-to-date, outperforming the industry growth of 24.1% and the S&P 500's 8.2% improvement [6] - The company's current valuation is high, trading at a forward 12-month Price-to-Sales (P/S) ratio of 7.84X, compared to the industry average of 5.90X [8] Earnings Estimates - Recent projections indicate an improvement in Tempus AI's projected loss per share, with a 2.8% improvement for 2025 and a 12% improvement for 2026 [10]