Core Insights - Guardant Health Inc. shares increased over 25% to $90 in premarket trading following strong financial results for Q3 2025 and an upward revision of its full-year outlook [1][3][4] Financial Performance - For Q3 2025, revenue reached $265.2 million, marking a 39% increase from $191.5 million in Q3 2024, primarily due to a 40% year-over-year growth in Oncology test volume [3] - The non-GAAP net loss for Q3 2025 narrowed to $48.3 million or $0.39 per share, compared to a loss of $55.0 million or $0.45 per share in the same quarter last year [3] Future Outlook - The company now anticipates full-year 2025 revenue between $965 million and $970 million, an increase from the previous guidance of $915 million to $925 million [4] Product Offerings - Guardant Health provides several tests including the Guardant360 Liquid test, Guardant360 CDx test, Guardant Reveal blood test, and Guardant360 Response blood test, which are designed for various cancer diagnostics and monitoring [2] - The company also introduced Shield, a blood-based screening test for colorectal cancer, which is now available through a collaboration with Quest Diagnostics [5] Stock Performance - Over the past year, Guardant Health's stock has fluctuated between $21.85 and $73.31, closing at $72.27, up 3.87% prior to the recent surge [6]

Company Overview - Tempus AI, Inc. has launched xM for treatment response monitoring (TRM), a liquid biopsy assay aimed at detecting molecular responses to immune-checkpoint inhibitor (ICI) therapy in advanced solid tumors, enhancing its portfolio of assays for monitoring molecular response and minimal residual disease (MRD) [1][7] - The xM for TRM utilizes a multi-parametric algorithm to assess changes in circulating tumor DNA (ctDNA) from blood samples, allowing for early molecular response evaluation in patients undergoing ICI therapies [3][7] Industry Insights - The increasing incidence of various cancers, including lung, breast, bladder, and cervical cancers, has led to a growing adoption of immune checkpoint inhibitor therapies, which are projected to drive the global immune checkpoint inhibitors market to $154.25 billion by 2030, with a CAGR of 17.9% from 2024 to 2030 [2] - Competitors in the industry, such as Exact Sciences and Guardant Health, are also advancing their product offerings, with Exact Sciences launching new tests for colon cancer screening and molecular residual disease monitoring, while Guardant Health has enhanced its liquid biopsy tests with new applications and comprehensive biomarker testing [4][5] Financial Performance - Tempus AI's stock has seen a significant increase of 91% year-to-date, outperforming the industry growth of 24.1% and the S&P 500's 8.2% improvement [6] - The company's current valuation is high, trading at a forward 12-month Price-to-Sales (P/S) ratio of 7.84X, compared to the industry average of 5.90X [8] Earnings Estimates - Recent projections indicate an improvement in Tempus AI's projected loss per share, with a 2.8% improvement for 2025 and a 12% improvement for 2026 [10]