Progranulin (PGRN)-Elevating Franchise - Alector's pivotal Phase 3 data readout for Latozinemab (AL001) in FTD-GRN is expected by mid-Q4 2025[13, 65] - The Phase 2 clinical trial for Nivisnebart (AL101/GSK4527226) in Alzheimer's Disease completed enrollment in April 2025[13, 68] - Latozinemab and nivisnebart have demonstrated a 2- to 3-fold increase in PGRN levels in clinical trials[50] - In the INFRONT-2 trial, Latozinemab treatment showed an estimated ~48% slowing of annual disease progression in FTD-GRN participants compared to historical controls, representing a 31-point change[61] Alector Brain Carrier (ABC) Platform - Alector expects to initiate a first-in-human clinical trial with its Alector Brain Carrier in 2026[13, 120] - AL037, an ABC-enabled anti-Aβ antibody, at 3mg/kg reached 38 nM in vessel-containing frontal cortex in NHP, showing an 18x increase compared to the naked antibody[114] - AL137, a second anti-Aβ antibody lead, at 3mg/kg reached 84 nM in vessel-containing frontal cortex in NHP, showing a 32x increase compared to the naked antibody[117] - AL050, an ABC-enabled GCase ERT, demonstrated a 5- to 19-fold enhancement in brain delivery in NHPs[149] - Peripheral delivery of SOD1 siRNA-ABC resulted in 50-80% knockdown across multiple brain structures in mice[171] Financial Resources - Alector has over $300 million in cash, providing a runway into the second half of 2027[13]