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MindRank Announces First Patient Dosed in Phase III Trial of AI-Designed Oral GLP-1 Receptor Agonist MDR-001
Globenewswire· 2026-02-26 02:22
Core Insights - MindRank has initiated the Phase III clinical trial for MDR-001, an AI-designed oral GLP-1 receptor agonist aimed at treating obesity and type 2 diabetes in China [1][2] - The trial, named MOBILE, will involve approximately 750 patients across 50 clinical centers, assessing the long-term efficacy and safety of MDR-001 [2] - MDR-001 has shown promising results in a Phase IIb trial, demonstrating clinically meaningful efficacy and favorable tolerability [3] Company Overview - MindRank is a clinical-stage biotechnology company that leverages AI for drug discovery, focusing on "hard-to-drug" targets to enhance the efficiency and success rate of new drug development [9] - The company utilizes its proprietary AI platform, Molecule Pro™, which integrates various scientific disciplines to optimize drug discovery processes [7][9] Technology and Innovation - The Molecule Pro™ platform employs advanced AI techniques, including deep learning and generative AI, to facilitate drug discovery and optimize lead compounds [7][8] - The platform's capabilities include predicting drug safety and optimizing molecular design to improve the chances of successful drug development [8] Development Milestones - The development of MDR-001 progressed from project initiation to U.S. IND clearance in 19 months and reached Phase III within approximately 4.5 years [4] - The dosing of the first patient in Phase III is considered a significant milestone for both MDR-001 and AI-driven drug development [6]