Core Insights - BillionToOne, Inc. has announced a collaboration with Epic to integrate its prenatal and oncology testing portfolio with Epic's Aura diagnostics suite, enhancing the patient and provider experience [1][2][3] Company Overview - BillionToOne is a next-generation molecular diagnostics company based in Menlo Park, California, focused on creating accessible and accurate tests [5] - The company utilizes a patented Quantitative Counting Templates™ (QCT™) molecular counting platform, which is the only multiplex technology capable of accurately counting DNA molecules at the single-molecule level [5] Integration Details - The integration allows clinicians to order BillionToOne's UNITY Complete® prenatal test and Northstar Select® and Northstar Response® liquid biopsy tests directly within Epic's EHR [2][4] - Test results will flow back into the electronic health record, facilitating clinical decision support and improving the experience for patients and providers across various healthcare settings [2][4] Clinical Impact - UNITY Complete is the first clinically validated non-invasive prenatal test that provides direct fetal risk assessment for multiple conditions from a single maternal blood sample [3] - Northstar Select assists in identifying appropriate therapies for advanced cancer patients, while Northstar Response enables ongoing treatment monitoring [3] User Experience Enhancement - Results will be delivered directly into Epic and accessible through the MyChart patient portal, promoting faster clinical decision-making and a more connected patient experience [4]

Table of Contents As filed with the Securities and Exchange Commission on October 17, 2025. Registration Statement No. 333-290761 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 AMENDMENT NO.1 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 BILLIONTOONE, INC. (Exact name of Registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 8071 81-1082020 (Primary Standard Industrial Classification Code Number) 1035 O'B ...

Table of Contents As filed with the Securities and Exchange Commission on October 7, 2025. Registration Statement No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 BILLIONTOONE, INC. (Exact name of Registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 8071 81-1082020 (Primary Standard Industrial Classification Code Number) 1035 O'Brien Drive Menlo Park, CA ...