Summary of Zoetis Update / Briefing December 02, 2025 Company Overview - **Company**: Zoetis (NYSE: ZTS) - **Industry**: Animal Health - **Market Size**: Total addressable market is approximately $50 billion, expected to nearly double by 2035 [4][38] Core Insights and Arguments 1. **Innovation and R&D Commitment**: Zoetis emphasizes its strong commitment to research and development, which is crucial for pioneering new solutions in animal health [1][2][3] 2. **Market Dynamics**: The company identifies a new generation of pet owners driving demand for high-quality veterinary care, leading to increased medicalization and longer pet lifespans [5][8] 3. **Chronic Disease Management**: There is a growing demand for advanced therapies in chronic conditions such as chronic kidney disease, oncology, and cardiology, which are becoming more prevalent as pets age [9][28] 4. **Livestock Market Resilience**: The livestock sector is experiencing mid-single-digit growth, driven by global demand for safe, sustainable animal protein, with a shift from treatment to prevention [11][12] 5. **Technological Advancements**: The integration of AI, genetics, and precision health is enhancing R&D capabilities, allowing for earlier insights and more personalized medicine [6][15] Pipeline and Future Opportunities 1. **Diverse Pipeline**: Zoetis has a robust pipeline with 12 products identified as having blockbuster potential, focusing on unmet medical needs in chronic kidney disease, oncology, and cardiology [25][38] 2. **Regulatory Approvals**: The company anticipates significant regulatory approvals in the coming years, with a major market approval expected annually [42][24] 3. **Investment in R&D**: Over $5 billion has been invested in R&D since 2013, resulting in over 2,000 regulatory approvals in the past decade [13][14] Key Areas of Focus 1. **Chronic Kidney Disease (CKD)**: CKD is a major unmet need, with 80% of cats and 10% of dogs likely to develop the condition by age 13. Zoetis is developing seven assets to address this [31][50] 2. **Oncology**: Cancer is a leading cause of death in dogs, with Zoetis targeting lymphoma and melanoma through innovative therapies [34][52] 3. **Cardiology**: The company is developing novel therapeutics for cardiovascular diseases, aiming to provide better outcomes for affected pets [35] Market Trends and Consumer Behavior 1. **Pet Ownership Trends**: Rising pet ownership and increased spending on pet care are driving growth in the animal health market [37][43] 2. **Consumer Expectations**: There is a growing demand for transparency and sustainability in animal care, influencing product development and market strategies [6][11] Financial Performance and Growth Strategy 1. **Sustainable Growth**: Zoetis has delivered high single-digit growth over the past five years, with strong margins and returns on invested capital [41][42] 2. **Capital Allocation**: The company maintains a disciplined approach to capital allocation, ensuring that investments in innovation align with market needs [39][40] Additional Insights 1. **Global Reach and Scale**: Zoetis's extensive global network and manufacturing capabilities position it as a leader in the animal health industry [12][63] 2. **Collaboration and Partnerships**: The company leverages external collaborations to enhance its R&D efforts and expand its innovation pipeline [23][24] This summary encapsulates the key points from the Zoetis update, highlighting the company's strategic focus on innovation, market dynamics, and future growth opportunities in the animal health sector.