Core Insights - Prime Medicine, Inc. is participating in the 8th Annual Evercore Healthcare Conference on December 2, 2025, with CEO Allan Reine as a speaker [1] - The company focuses on developing a new class of one-time curative genetic therapies using its proprietary Prime Editing platform [3] Company Overview - Prime Medicine is a biotechnology company dedicated to gene editing therapies, utilizing a precise and efficient technology that minimizes unwanted DNA modifications [3] - The Prime Editing platform has the potential to repair various genetic mutations across multiple tissues, organs, and cell types, unlocking opportunities for thousands of potential indications [3] Therapeutic Programs - The company is advancing a diversified portfolio of investigational therapeutic programs in core areas such as liver, lung, immunology, and oncology [4] - Each program targets diseases with well-understood biology and a clear clinical development path, aiming to expand into additional opportunities over time [4] - Prime Medicine plans to leverage the versatility of its Prime Editing platform to address a wide range of genetic, immunological, and infectious diseases, impacting millions of people [4]

Core Insights - Prime Medicine, Inc. is a biotechnology company focused on developing one-time curative genetic therapies using its proprietary Prime Editing platform [3][4] - The CEO, Allan Reine, will participate in a fireside chat at the Jefferies Global Healthcare Conference on November 18, 2025 [1] - A live audio webcast of the event will be available on the company's website, with a replay accessible for 90 days post-event [2] Company Overview - Prime Medicine is dedicated to creating advanced gene editing therapies, aiming to repair various genetic mutations across multiple tissues and organs [3] - The company is advancing a diversified portfolio of therapeutic programs primarily in liver, lung, immunology, and oncology [4] - Prime Medicine plans to expand its therapeutic potential beyond current diseases to include genetic, immunological, and infectious diseases, impacting millions of people [4]

Core Insights - Prime Medicine, Inc. is set to host a virtual event on November 12, 2025, to discuss its liver disease franchise, particularly focusing on Wilson's Disease [1][2] - The company plans to file an investigational new drug (IND) and/or clinical trial application (CTA) for PM577, targeting H1069Q-driven Wilson's Disease, in the first half of 2026, with initial clinical data expected in 2027 [1][8] Company Overview - Prime Medicine is a biotechnology company focused on developing a new class of one-time curative genetic therapies using its proprietary Prime Editing platform, which allows precise and efficient gene editing [4][5] - The company is advancing a diversified portfolio of investigational therapeutic programs in core areas such as liver, lung, immunology, and oncology, targeting diseases with well-understood biology [5] Strategic Focus - The upcoming event will feature presentations from the management team and Dr. Michael Schilsky, highlighting the treatment landscape for Wilson's Disease, which currently lacks a curative therapy [2][8] - Prime Medicine aims to leverage the modularity of its Prime Editing platform to accelerate the development of multiple Prime Editors for Wilson's Disease and potentially other diseases [8][9] Market Opportunity - The company identifies a significant global market opportunity for Wilson's Disease treatment, noting that current standard-of-care options are limited by compliance, cost, and tolerability [8] - Prime Editing technology has the potential to provide durable cures by precisely addressing the genetic causes of Wilson's Disease, which could impact millions of patients [8][9]

Group 1 - Prime Medicine, Inc. closed its underwritten public offering of 43,700,000 shares of common stock at a price of $3.30 per share, raising approximately $144.2 million in gross proceeds before expenses [1] - The offering included the full exercise of the underwriters' option to purchase an additional 5,700,000 shares, with no discounts or commissions for 1,818,181 shares sold to the Cystic Fibrosis Foundation [1] - TD Cowen and BMO Capital Markets served as joint book-running managers for the offering [2] Group 2 - The shares were offered under an effective shelf registration statement filed with the SEC on November 3, 2023, and declared effective on November 13, 2023 [3] - A final prospectus supplement detailing the terms of the offering was filed with the SEC and is available on their website [3] Group 3 - Prime Medicine is focused on developing a new class of one-time curative genetic therapies using its proprietary Prime Editing platform, which aims for precise and efficient gene editing [6] - The company is advancing a diversified portfolio of investigational therapeutic programs in core areas such as liver, lung, immunology, and oncology, targeting diseases with well-understood biology [7]

Core Points - Prime Medicine, Inc. announced a public offering of 38,000,000 shares at a price of $3.30 per share, aiming to raise approximately $125.4 million in gross proceeds before expenses [1] - The offering includes a 30-day option for underwriters to purchase an additional 5,700,000 shares [1] - The offering is expected to close around August 1, 2025, pending customary closing conditions [1] Company Overview - Prime Medicine is a biotechnology company focused on developing one-time curative genetic therapies using its proprietary Prime Editing platform, which allows for precise gene editing [6] - The company is advancing a portfolio of investigational therapeutic programs in core areas such as liver, lung, immunology, and oncology, targeting diseases with well-understood biology [7] Offering Details - The shares are being offered under an effective shelf registration statement filed with the SEC on November 3, 2023, and declared effective on November 13, 2023 [3] - The final prospectus supplement will be filed with the SEC and will be available through designated contacts [4]

Core Viewpoint - Prime Medicine, Inc. has initiated an underwritten public offering of its common stock, with plans to grant underwriters a 30-day option to purchase an additional 15% of the shares offered [1] Company Overview - Prime Medicine is a biotechnology company focused on developing a new class of one-time curative genetic therapies using its proprietary Prime Editing platform, which aims to provide precise and efficient gene editing [6] - The company is advancing a diversified portfolio of investigational therapeutic programs in core areas such as liver, lung, immunology, and oncology, targeting diseases with well-understood biology and clear clinical development paths [7] Offering Details - The shares are being offered under an effective shelf registration statement filed with the U.S. Securities and Exchange Commission (SEC) on November 3, 2023, and declared effective on November 13, 2023 [3] - The final terms of the offering will be disclosed in a final prospectus supplement to be filed with the SEC [5]