Core Insights - IBA announces that a landmark study published in The Lancet recommends proton therapy as the new standard of care for oropharyngeal cancer, providing the highest level of evidence for its benefits over conventional radiotherapy [1][4]. Industry Overview - Oropharyngeal cancer is a significant global health issue, with over 100,000 new cases diagnosed annually. Current treatments often lead to severe side effects, highlighting the need for more effective therapies [2]. Clinical Trial Details - The study involved over 20 institutions and enrolled 440 patients, marking the first level 1 randomized phase 3 trial comparing Intensity-Modulated Proton Therapy (IMPT) with advanced photon therapy (IMRT) [3]. - The trial provides strong evidence for proton therapy's safety and effectiveness, establishing it as a transformative solution for oropharyngeal cancer [3]. Key Findings - The five-year overall survival rate for patients receiving IMPT is 90.9%, compared to 81.0% for those receiving IMRT, indicating a significant improvement in survival [6]. - IMPT also shows a 42% reduction in the hazard of death and significantly lower rates of severe toxicities compared to IMRT [6]. Expert Commentary - Experts emphasize the importance of this study in establishing proton therapy as the standard of care for advanced oropharyngeal cancer, with potential for increased accessibility for patients [4].

(Article 14, paragraph 1 of the law of 2 May 2007 on the disclosure of major holdings) Louvain-la-Neuve, Belgium, April 28th, 2024 06:00 PM Summary of the notification IBA (Ion Beam Applications), the world’s leading provider of proton therapy solutions for the treatment of cancer, announces that it has to issue a transparency notification, in accordance with Article 14, al. 1 of the Transparency Law of May 2, 2007 on disclosure of major holdings, further to the notification received on April 8th, 2025. I ...