Key Takeaways VNDA won FDA approval for tradipitant, branded Nereus, to prevent vomiting caused by motion sickness.Vanda Pharmaceuticals said Nereus is the first new motion sickness drug in more than 40 years.VNDA shares surged 18% after hours following the approval, extending gains into pre-market trading.Vanda Pharmaceuticals, Inc. (VNDA) announced that the FDA has approved its candidate tradipitant for the prevention of vomiting induced by motion.The drug has been approved under the brand name Nereus.Tra ...

Core Insights - Lexaria Bioscience Corp. has successfully completed its Phase 1b, 12-week chronic study GLP-1-H24-4 in Australia, demonstrating superiority in reducing side effects compared to Novo Nordisk's Rybelsus [1][2] Study Results - The study achieved its primary endpoint, showing that all four DehydraTECH (DHT) formulations were safe and well tolerated, with lower rates of treatment-emergent adverse events (AEs) compared to Rybelsus [3] - DHT-semaglutide showed a 47.9% reduction in total AEs and a 54.9% reduction in gastrointestinal AEs compared to Rybelsus [4] - The reduction in HbA1c levels was comparable between DHT-semaglutide and Rybelsus, but bodyweight reduction was better in the Rybelsus arm at both week 12 and week 16 evaluations [5] Future Development - Lexaria plans to further develop the DHT-semaglutide formulation and is considering incorporating salcaprozate sodium (SNAC) in future studies [6] - The company is evaluating options for follow-on human clinical testing of a DehydraTECH + SNAC + semaglutide formulation against Rybelsus [6][7] Market Reaction - Following the news, Lexaria's stock (LEXX) experienced a decline of 7.42%, trading at $0.63 [8]