Core Insights - Adagene has partnered with ConjugateBio to provide a proprietary antibody for the development of bispecific antibody-drug conjugates (ADCs) [1][2][3] - The ADC market is projected to exceed $30 billion by 2030, indicating significant growth potential in this sector [2] - Adagene will receive an undisclosed upfront payment along with milestone and royalty payments, while retaining all non-ADC rights to the partnered antibody [3] Company Overview: Adagene - Adagene Inc. is a clinical-stage biotechnology company focused on novel antibody-based cancer immunotherapies, utilizing computational biology and artificial intelligence [4] - The company employs its SAFEbody precision masking technology to enhance safety and tolerability in antibody therapeutics, allowing for targeted action in the tumor microenvironment [5] - Adagene's lead clinical program, ADG126, is currently in phase 1b/2 studies for metastatic microsatellite-stable colorectal cancer, showcasing the application of its SAFEbody platform [6] Company Overview: ConjugateBio - ConjugateBio is a privately held biotechnology company specializing in first-in-class bispecific ADCs targeting solid tumors, leveraging advanced linker-payload technologies [8] - The company aims to develop innovative therapeutics across a wide range of cancer indications, indicating a strong focus on addressing unmet medical needs in oncology [8]

Core Insights - Adagene Inc. has appointed Dr. John Maraganore as Executive Advisor to provide strategic guidance and mentorship to the company's leadership team [1][2] Company Overview - Adagene Inc. is a clinical-stage biotechnology company focused on developing novel antibody-based cancer immunotherapies, utilizing computational biology and artificial intelligence [4] - The company has established strategic collaborations with global partners to leverage its SAFEbody precision masking technology [4] Technology and Innovation - Adagene's proprietary Dynamic Precision Library (DPL) platform includes NEObody™, SAFEbody®, and POWERbody™ technologies, aimed at addressing safety and tolerability challenges in antibody therapeutics [5] - The SAFEbody technology allows for tumor-specific targeting of antibodies while minimizing on-target off-tumor toxicity in healthy tissues [5] Clinical Development - Adagene's lead clinical program, ADG126 (muzastotug), is a masked anti-CTLA-4 SAFEbody currently in phase 1b/2 clinical studies, particularly targeting Metastatic Microsatellite-stable Colorectal Cancer [6] - The SAFEbody platform is validated for application across various antibody-based therapeutic modalities, including Fc empowered antibodies and antibody-drug conjugates [6] Leadership and Expertise - Dr. John Maraganore previously served as CEO of Alnylam, where he led the company through the approval and commercialization of four RNA interference therapeutic medicines, creating over $25 billion in market capitalization [2][3] - He has extensive experience advising and mentoring life sciences CEOs and sits on the boards of public and private companies [3]