Core Insights - Amarin Corporation has transitioned to a fully partnered commercialization model across all international markets, which is expected to enhance its operational efficiency and market reach [1][3] - The Q3 2025 financial results indicate a positive trend with a 17% increase in total net revenue compared to Q3 2024, driven primarily by strong U.S. sales [4][6] - The company aims to achieve sustainable positive free cash flow by 2026, reflecting confidence in its strategic actions and operational improvements [1][4] Financial Performance - Total net revenue for Q3 2025 was $49.7 million, up from $42.3 million in Q3 2024, marking a 17% increase [4][6] - Product revenue, net increased by 16% to $48.6 million, primarily due to higher U.S. sales, which rose by 34% to $40.9 million [5][7] - Operating expenses decreased by 20% to $33.3 million, largely due to a restructuring plan implemented in June 2025 [9][12] Operating Metrics - The operating loss for Q3 2025 was $11.1 million, significantly improved from a loss of $25.2 million in Q3 2024, reflecting a 56% reduction [4][14] - The net loss for Q3 2025 was $7.7 million, compared to a net loss of $25.1 million in the same quarter of the previous year, indicating a 69% improvement [15][34] - Cash and investments at the end of Q3 2025 totaled $286.6 million, down from $305.7 million in Q3 2024 [15] Strategic Initiatives - The company has established partnerships with seven parties across nearly 100 countries to leverage regional expertise and infrastructure for the commercialization of VASCEPA/VAZKEPA [3][17] - Amarin is focused on enhancing shareholder value through strategic actions and is optimistic about its global business potential [3][4]

Core Insights - The 2025 ESC/EAS Dyslipidemia Guideline Update reaffirms high-dose icosapent ethyl (IPE) as a Class IIA recommended therapy for high-risk or very high-risk patients to reduce cardiovascular events based on the REDUCE-IT trial findings [1][14] Group 1: REDUCE-IT Trial Findings - Three sub-analyses from the REDUCE-IT trial demonstrate significant reductions in cardiovascular disease (CVD) risk and outcomes associated with IPE administration in patients with cardiovascular-kidney-metabolic (CKM) syndrome, stratified by baseline apolipoprotein B (ApoB) and fasting triglyceride-rich lipoprotein cholesterol (TRL-C) levels [1][2] - IPE treatment showed a 44% relative risk reduction (RRR) for the primary composite endpoint in patients with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m², with a hazard ratio (HR) of 0.56 (95% CI 0.39, 0.79), P = 0.001, and an absolute risk reduction (ARR) of 11.2% [4][5] Group 2: Impact on Major Adverse Cardiovascular Events (MACE) - IPE treatment resulted in significant reductions in MACE across all quartiles of baseline ApoB and TRL-C concentrations, with HRs ranging from 0.72 to 0.80 for ApoB and from 0.74 to 0.68 for TRL-C, all with P ≤ 0.02 [8][9] Group 3: Hospitalization and Mortality Outcomes - IPE significantly reduced total hospitalizations (HR 0.91, 95% CI 0.84, 0.98, P=0.017) and increased the likelihood of surviving without hospitalization (odds ratio (OR) 1.12, 95% CI 1.02, 1.22, P=0.016) [12][13] Group 4: Clinical Recommendations - The ESC/EAS guidelines recommend high-dose IPE for patients with elevated triglyceride levels (135–499 mg/dL) despite statin therapy, emphasizing its role in reducing CVD events [14]

Core Insights - Amarin Corporation will present new data on icosapent ethyl (IPE) at the European Society of Cardiology (ESC) Congress 2025, highlighting its cardioprotective effects [1][2] - The data will focus on IPE's role in reducing cardiovascular risk through various mechanisms, including inflammation and lipoprotein oxidation [2][3] Presentation Highlights - New analyses from the REDUCE-IT trial will evaluate the clinical benefits of IPE, including its impact on hospitalization risk and duration [2][3] - Mechanistic studies will explore the effects of eicosapentaenoic acid (EPA) on inflammasome activation and pro-inflammatory protein expression in endothelial cells [2][3] Educational Initiatives - Amarin will support educational programming addressing residual cardiovascular risk, featuring presentations by medical and scientific leaders in Europe [3][5] Symposium and Abstracts - Moderated poster presentations will include topics such as the reduction of cardiovascular disease risk in cardiovascular-kidney-metabolic syndrome and the impact of IPE across different apolipoprotein B and triglyceride levels [4][7] - Oral presentations will cover the effects of IPE on hospitalization risks and the modulation of inflammasome activation in macrophages [7] Company Overview - Amarin is focused on advancing cardiovascular disease management and understanding residual cardiovascular risk beyond traditional therapies [8] - The company has a global presence with offices in the United States, Ireland, Switzerland, and partnerships worldwide [8] Product Information - VASCEPA (icosapent ethyl) is the first FDA-approved treatment solely comprising IPE, aimed at high-risk patients with persistent cardiovascular risk despite statin therapy [9] - Since its launch, VASCEPA has been prescribed over 25 million times and is covered by most major medical insurance plans [9]