NEW HOPE, Pa., March 03, 2026 (GLOBE NEWSWIRE) -- Orchestra BioMed Holdings, Inc. (Nasdaq: OBIO) (“Orchestra BioMed” or the “Company”), a biomedical company accelerating high-impact technologies to patients through strategic partnerships with market-leading global medical device companies, today announced two presentations that will be given at the Technology Heart Failure and Therapeutics (“THT”) and Cardiovascular Research Technologies (“CRT”) 2026 Meetings highlighting the potential for the Company’s Atr ...

Core Insights - Orchestra BioMed is collaborating with Medtronic to develop and commercialize AVIM Therapy for treating uncontrolled hypertension in patients indicated for a pacemaker [1][4] - The company presented at the 2025 Innovation in Cardiology Intervention meeting, focusing on AVIM Therapy and Virtue Sirolimus AngioInfusion™ Balloon [1][2] Company Overview - Orchestra BioMed is a biomedical innovation company that accelerates high-impact technologies through strategic collaborations with leading medical device companies [4] - The two flagship products, AVIM Therapy and Virtue SAB, represent multi-billion-dollar annual global market opportunities [4] AVIM Therapy - AVIM Therapy is designed to lower blood pressure significantly and persistently in patients with hypertension who are also indicated for a pacemaker [5][6] - Pilot studies showed net reductions of 8.1 mmHg in ambulatory systolic blood pressure and 12.3 mmHg in office systolic blood pressure at six months compared to control patients [6] - The BACKBEAT global pivotal study is currently evaluating the safety and efficacy of AVIM Therapy in patients with systolic blood pressure above target despite anti-hypertensive medication [6] Virtue Sirolimus AngioInfusion™ Balloon (Virtue SAB) - Virtue SAB is a novel drug delivery system designed for coronary artery disease treatment, utilizing a non-coated microporous AngioInfusion™ Balloon [3][7] - The system delivers a proprietary extended-release formulation of sirolimus, achieving sustained tissue levels above the therapeutic concentration required to inhibit restenosis [7] - Virtue SAB has shown positive three-year clinical data in coronary in-stent restenosis and has received Breakthrough Device Designation from the FDA for multiple indications [7]

Core Insights - Orchestra BioMed Holdings, Inc. has granted stock options to 12 newly hired employees, totaling 151,250 shares, as part of its 2025 New Hire Inducement Plan [1][2] - The stock options will vest 25% on the first anniversary of employment, with the remainder vesting quarterly over three years [2] Company Overview - Orchestra BioMed is focused on accelerating high-impact biomedical technologies through partnerships with leading global medical device companies [3] - The company's flagship products include Atrioventricular Interval Modulation (AVIM) Therapy for hypertension and Virtue Sirolimus AngioInfusion™ Balloon (Virtue SAB) for atherosclerotic artery disease, both targeting multi-billion-dollar market opportunities [3] - AVIM Therapy aims to provide significant blood pressure reduction in patients with hypertensive heart disease and has FDA Breakthrough Device Designation [3] - Virtue SAB is a novel drug delivery system for treating coronary ISR, small vessel disease, and below-the-knee peripheral artery disease, also granted Breakthrough Device Designation by the FDA [3]