Financial Data and Key Metrics Changes - Total revenue for Q3 2025 was $149 million, down 2% year-over-year but up 2% sequentially, excluding one-time license and royalty revenue from Q2 [4][16] - Total consumables revenue was $127.9 million, up 1%, while Chromium consumables revenue was $92.5 million, down 4% due to lower average selling prices [16] - Gross profit for Q3 was $100.3 million, with a gross margin decrease to 67% from 70% the prior year, primarily due to changes in product mix and higher inventory write-downs [18] - Operating loss for Q3 was $32.2 million, an improvement from a loss of $41.5 million in the same period last year [18] - The company ended the quarter with $482 million in cash, cash equivalents, and marketable securities, reflecting a $35 million increase from the prior quarter [19] Business Line Data and Key Metrics Changes - Spatial consumables revenue was $35.4 million, up 19%, driven by strong demand for Xenium consumables [16] - Total instrument revenue was $12 million, down 37%, with Chromium instrument revenue at $4.9 million, down 36% [16] - Services revenue increased by 29% to $8.1 million, primarily due to an increase in Xenium service plans [17] Market Data and Key Metrics Changes - Americas revenue was $79.9 million, down 9% year-over-year, while AMEA revenue was $41.6 million, up 10% [17] - APAC revenue was $27.5 million, up 6% year-over-year but down 14% sequentially due to a customer-driven pull forward in Q2 [17] Company Strategy and Development Direction - The company is focused on advancing its innovation roadmap and driving greater adoption of its products, with recent product launches and partnerships aimed at addressing data analysis bottlenecks [6][11] - The introduction of the next generation of Chromium Flex is expected to enhance scalability and support AI-driven initiatives [8] - The company sees a growing opportunity in translational research and clinical applications, as evidenced by collaborations with institutions like CLI-SEQ and the Weizmann Institute [12][14] Management's Comments on Operating Environment and Future Outlook - Management noted ongoing funding pressures and policy uncertainty but expressed confidence in the company's ability to navigate these challenges and invest in long-term growth [6][19] - The outlook for Q4 anticipates revenue in the range of $154 million to $158 million, reflecting a 5% growth compared to Q3 at the midpoint [19] - Management emphasized the importance of maintaining flexibility in customer engagements amid cautious spending behavior [6][19] Other Important Information - The company is experiencing strong customer enthusiasm for its products, particularly Xenium, which is becoming the preferred solution for spatial biology needs [10] - The partnership with Anthropic aims to make data analysis more accessible through integration with Claude for life sciences [11] Q&A Session Summary Question: Can you walk through how much of the expected 5% sequential pickup in Q4 is anticipated from instruments versus consumables? - Management indicated a potential uptick on the instrument side in Q4, factoring in the government shutdown's impact on guidance [25][26] Question: What are the contributions from Xenium and Visium in spatial consumables? - Management noted a consistent increase in usage of the Xenium platform, with a trend towards more runs and price per run [37][39] Question: Can you elaborate on early adoption trends for Xenium Protein? - Initial feedback on Xenium Protein has been positive, with customers excited about the capability to measure both proteins and RNA from the same sample [51][52] Question: What impact is the transition from NextGen to GEM-X expected to have? - Management stated that the bulk of the effects on P&L from this transition have already been realized, with remaining impacts being marginal [70] Question: How is the company addressing the macroeconomic challenges in the pharma segment? - Management acknowledged challenges in the pharma segment but noted positive trends in large-scale experiments and translational applications [60][61]

Core Insights - 10x Genomics reported a revenue of $149.0 million for Q3 2025, reflecting a 2% decrease compared to Q3 2024, primarily due to a decline in instrument revenue [3][12] - The company experienced a gross margin of 67% in Q3 2025, down from 70% in the same period last year, attributed to changes in product mix and higher inventory write-downs [4] - Operating expenses decreased by 10% to $132.5 million in Q3 2025, driven by lower personnel and legal expenses, resulting in an operating loss of $32.2 million [5] - The net loss for Q3 2025 was $27.5 million, an improvement from a net loss of $35.8 million in Q3 2024 [6] - Cash and cash equivalents, along with marketable securities, totaled $482.1 million as of September 30, 2025, marking a $35 million increase from the previous quarter [12] Financial Performance - Revenue breakdown: - Products and services revenue was $148.0 million, with consumables contributing $127.9 million and instruments $11.9 million [14] - License and royalty revenue was $983,000 [14] - Sequential revenue comparison: Q3 2025 revenue was $149.0 million, compared to $172.9 million in Q2 2025, which included $27.3 million from one-time license and royalty revenue [12] - Operating loss improved from $41.5 million in Q3 2024 to $32.2 million in Q3 2025 [5] Future Guidance - For Q4 2025, 10x Genomics anticipates revenue between $154 million and $158 million, indicating a 6% decline year-over-year but a 5% growth sequentially at the midpoint [7] Product Developments - The company launched the next-generation Chromium Flex, aimed at cost-effective, scalable single-cell analysis [12] - The introduction of Xenium Protein, a fully-integrated spatial multiomic workflow, allows simultaneous RNA and protein detection on the same tissue section [12] Market Position - 10x Genomics is recognized as a leader in single-cell and spatial biology, providing integrated research solutions that support advancements in various fields, including oncology and immunology [9]

Core Insights - 10x Genomics has launched Xenium Protein, the first fully integrated spatial multiomic assay that allows simultaneous RNA and protein detection in the same cell and tissue section, enhancing biological insights without the need for data integration from multiple technologies [1][2] Group 1: Product Features - Xenium Protein expands the Xenium Spatial platform with ready-to-use protein subpanels that work seamlessly with RNA panels, focusing on proteins involved in cell growth, signaling, and immune response, which are crucial for studying cancer and immunology [2][4] - The new assay simplifies experimental design by reducing the need for separate workflows or sample sections, allowing researchers to capture both RNA and protein data in a single automated run, thus accelerating the pace of discoveries [3][4] Group 2: Industry Impact - Integrated multiomic analysis is essential for advancing the understanding of complex diseases and accelerating therapeutic discovery, as highlighted by industry experts [2][4] - Early access customers are already utilizing Xenium Protein for various research applications, from early discovery to large-scale atlasing efforts, indicating its broad applicability in the field [3]