Core Insights - Novartis is investing $23 billion to expand its U.S. manufacturing and R&D footprint over the next five years [3] - Approximately 42% of Novartis' annual revenue last year came from U.S. sales, highlighting the importance of the U.S. market [4] - The new manufacturing hub in North Carolina will create 700 jobs by 2030 and is expected to enhance operational efficiencies [6][8] Investment Details - The North Carolina manufacturing hub will involve a total investment of $771 million [8] - The project includes constructing two new sites and expanding an existing facility, covering over 700,000 square feet [8] - The North Carolina Economic Investment Committee awarded Novartis a Job Development Investment Grant, potentially reimbursing nearly $7.56 million over 12 years [7] Strategic Goals - The manufacturing hub aims to produce all medicines from start to finish in the U.S., enhancing supply chain resilience [5][8] - The facilities will focus on manufacturing biologics, sterile packaging, and solid dosage forms [8] - Novartis is also establishing an R&D hub in San Diego and expanding existing sites in California, New Jersey, and Indiana [7]