Exscientia (EXAI) Investor Presentation _-Slideshow

Timeline for illustrative purposes EXS74539 ('539) (LSD1 inhibitor) • LSD1 demethylates histones, playing a critical role in suppressing the expression of genes required for cellular differentiation • Drives the proliferation and survival of several tumour types • LSD1 is overexpressed in many cancer types across haematology and oncology • Inhibiting LSD1 reactivates expression of genes driving differentiation; can inhibit cell growth and sensitise any remaining cells to other agents A brain penetrant LSD1 ...