Prothena(PRTA) - 2022 Q4 - Earnings Call Presentation

Global Neuroscience Collaboration with Bristol Myers Squibb – This propagation of pathology is thought to be mediated by tau "seeds" containing the MTBR of tau2 • Phase 1 SAD data in HVs demonstrated dose-proportional PRX005 concentrations in plasma with robust CNS penetration and generally safe and well tolerated 1Ahmed, Z., Cooper, J.. et al. A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proxim ...