Financial Data and Key Metrics Changes - Net sales for Q4 2024 were approximately 668million,a2681 million in Q4 2023, and a 2.3% decrease on a currency-neutral basis [23] - Full-year net sales for 2024 were 2.557billion,representinga3.92.671 billion in 2023, with a 3.6% decrease on a currency-neutral basis [30] - Q4 reported GAAP gross margin was 51.2%, down from 53.8% in Q4 2023, primarily due to restructuring expenses and reimbursement reductions [26] - Non-GAAP net income for Q4 2024 was 81million,or2.90 diluted earnings per share [30] Business Line Data and Key Metrics Changes - Life Science Group sales in Q4 2024 were 275million,adeclineof5.5291 million in Q4 2023, with a 6% decrease on a currency-neutral basis [23] - Clinical Diagnostics Group sales in Q4 2024 were approximately 393million,anincreaseof0.9389 million in Q4 2023, driven by demand for quality control and blood typing products [25] - Full-year sales for the Life Science Group were approximately 1.028billion,adeclineof12.81.178 billion in 2023, while Clinical Diagnostics Group sales increased by 3.3% to 1.538billion[31][32]MarketDataandKeyMetricsChanges−TheAsiaPacificregionsawadeclineindiagnosticperformanceduetoareimbursementchangefordiabetestestinginChina[13]−InEurope,fundingremainsmixed,withmodestincreasesinGermanyandtheUK,whileFrancecontinuestobesoft[18]−TheUSacademicandgovernmentsegmentrepresentsapproximatelyahighsingle−digitpercentageoftotalrevenue,withfederallyfundedresearchexposureestimatedatabout450 to 55millionin2025[27]−Full−yearfreecashflowfor2024wasapproximately290 million, with a target of 310millionto330 million for 2025 [38][47] Q&A Session Summary Question: Life sciences guidance and DDPCR growth - Management indicated that DDPCR growth is expected to be around 1% to 2%, with process chromatography projected to grow in the high single digits [56][57] Question: Process chromatography decline - Confirmation that the process chromatography product line declined more than 50% in Q4 and for the full year [65][66] Question: Operating margin bridge for 2025 - Management explained that the decline in operating margin is primarily due to China diagnostics and foreign currency effects, with additional impacts from R&D expenses [69][72] Question: Stilla acquisition rationale - The acquisition is seen as complementary, allowing the company to address both entry-level and high-end digital PCR markets [78][81] Question: First quarter sales forecast - Management expects Q1 sales to be down 5% to 7% year-over-year, with a gradual recovery anticipated throughout the year [91][93] Question: NIH funding impact - Management noted that researchers are in a wait-and-see mode regarding NIH funding changes, which may affect capital equipment spending [114] Question: DDPCR market growth and competition - The DDPCR market remains competitive, with the company focusing on maintaining market share through innovation and acquisitions [118][120]