Financial Data and Key Metrics Changes - Total revenue for the full year 2024 was 38.6million,a641.3 million in 2023 [28] - Total revenue in Q4 2024 was 8.7million,representinga4515.7 million in Q4 2023 [28] - Core revenue for Q4 2024 was 8.6million,anincreaseof207.2 million in the prior year [28] - Core revenue for the full year 2024 was 32.5million,up929.8 million in 2023 [30] - Gross margin for Q4 2024 was 74%, down from 90% in Q4 2023 [33] Business Line Data and Key Metrics Changes - Instrument revenue for Q4 2024 was 1.6million,downfrom2.3 million in Q4 2023 [29] - License revenue for Q4 2024 was 2.6million,slightlyupfrom2.4 million in Q4 2023 [29] - Processing assembly (PA) revenue for Q4 2024 was 4.2million,significantlyupfrom2.2 million in Q4 2023 [29] - For the full year 2024, instrument revenue was 7.1million,downfrom8.3 million in 2023 [30] - PA revenue for the full year 2024 was 14million,upfrom10.3 million in 2023 [30] Market Data and Key Metrics Changes - As of the end of 2024, there were 28 active SPL customers, including 18 active clinical programs and one commercial program [15] - The total pre-commercial milestone potential across SPL agreements is greater than 2billion[15]−Thetotalpre−commercialmilestonepotentialforthe18activeclinicalprogramsisgreaterthan220 million, with about 10millionalreadyreceived[16]CompanyStrategyandDevelopmentDirection−TheacquisitionofSeQureDxisseenasastrategicmovetoenhancesafetyassessmentsincellandgenetherapydevelopment[9]−Thecompanyaimstobecomeapremierend−to−endcellandgeneengineeringplatform,providingacomprehensivesuiteofofferings[12]−Thefocusremainsonorganicandinorganicinvestmentsthatofferthebestoutcomesforcustomerswhilemaintainingahealthybalancesheet[26]Management′sCommentsonOperatingEnvironmentandFutureOutlook−Managementexpressedcautiousoptimismfor2025,expectinganimprovementinthefundingenvironmentforcustomers[14]−Thecompanyiscommittedtomaintainingastreamlinedorganizationtosupportlong−termgrowth[37]−Managementnotedthattheoperationalchangesmadein2024havepositionedthecompanywellforfuturegrowth[8]OtherImportantInformation−Thecompanyended2024with190.3 million in cash and cash equivalents, with no debt [34] - The guidance for 2025 includes expected core revenue growth of 8% to 15%, inclusive of revenue from SeQure Dx [35] Q&A Session Summary Question: Guidance for Core business excluding SeQure Dx - Management indicated continued growth across the customer base and operational changes that should support year-over-year growth [41][42] Question: Revenue track record for SeQure Dx - SeQure Dx is expected to grow modestly in 2025, with a fee-for-service business model currently in place [46][49] Question: Integration costs for SeQure Dx - Integration costs are expected to be immaterial, leveraging existing commercial infrastructure [58][60] Question: Exposure to academic markets and NIH spending - The company's exposure to NIH grants is minimal, with no significant impact expected in the short term [64] Question: SPL environment and customer agreements - Most customers are still signing agreements at the pre-IND level, indicating a healthy business environment [68] Question: Combined company gross margins post-SeQure integration - Management expects combined gross margins to remain in the low to mid-80s [80] Question: Potential upside to top-line numbers for 2025 - The guidance is conservative, not assuming significant market recovery, but there is potential for upside if conditions improve [82][96]