Kiniksa(US:KNSA)2025-07-29 12:30ARCALYST Performance and Market - ARCALYST has generated over $1 billion in revenue since its launch[7] - Expected 2025 ARCALYST revenue is projected to be between $625 million and $640 million[7, 51] - ARCALYST has achieved approximately 15% penetration into the target population of recurrent pericarditis patients as of Q2 2025[7, 23, 29] - Approximately 80% of ARCALYST prescriptions are for patients with ≥3rd recurrence[23] - Approximately 20% of ARCALYST prescriptions are for patients in their 1st recurrence[23] - Payer approval for ARCALYST exceeds 90% of completed cases[28] - Approximately 45% of patients restarted ARCALYST therapy following initial discontinuation within ~8 weeks[37, 40] - The average total duration of ARCALYST therapy is approximately 30 months[28, 40] Financial Position - Kiniksa reported Q2 2025 cash reserves of approximately $308 million[8] - Kiniksa's operating plan is expected to remain cash flow positive on an annual basis[7, 78] - ARCALYST net sales for Q2 2025 were $156.8 million, compared to $103.4 million in Q2 2024[77] KPL-387 Development - A Phase 2/3 trial for KPL-387 in recurrent pericarditis has been initiated, with Phase 2 dose-focusing data expected in the second half of 2026[8]