ADC Therapeutics (ADCT) 2025 Conference Transcript

Summary of ADC Therapeutics Conference Call Company Overview - Company: ADC Therapeutics - Industry: Biotechnology, specifically focused on antibody-drug conjugates (ADCs) - Lead Product: ZYNLONTA (anti-CD19 ADC) approved for third-line treatment of diffuse large B-cell lymphoma (DLBCL) as a monotherapy [2][3] Core Points and Arguments - Market Opportunity: ADC Therapeutics estimates a peak sales opportunity for ZYNLONTA between $600 million to $1 billion, driven by ongoing clinical trials and a favorable competitive landscape [4][3] - Clinical Trials: - LOTIS-5: Phase 3 study combining ZYNLONTA with rituximab in second-line DLBCL, with data expected by the end of the year [5][15] - LOTIS-7: Phase 2 study combining ZYNLONTA with Roche's glofitamab, showing promising early results with a 93% overall response rate and 87% complete response rate in initial patients [25][27] - Competitive Landscape: The company believes that the DLBCL market is less competitive than perceived, with only 20% of patients receiving CAR-T therapy due to accessibility issues, leaving a significant opportunity for ZYNLONTA [7][9] Important Data Points - LOTIS-5 Expectations: Aiming for a progression-free survival (PFS) benefit of approximately 6 months over the current standard of care, with a complete response (CR) rate target of 40-50% [16][19] - LOTIS-7 Results: The combination therapy has shown a favorable safety profile with no new safety signals and a lower incidence of neutropenia compared to historical data [28][30] - Indolent Lymphomas: Ongoing studies in high-grade follicular and marginal zone lymphoma show promising early results, with a 97% overall response rate and 77% complete response rate in follicular lymphoma [42][43] Financial Position - Cash Position: ADC Therapeutics ended Q2 with $265 million in cash, providing a runway into 2028 [54] - Upcoming Catalysts: Expected revenue opportunities from potential approvals and guideline inclusions for LOTIS-5 and LOTIS-7 by the first half of 2027 [54] Additional Insights - Regulatory Engagement: The company is actively engaging with the FDA and plans to submit data for LOTIS-5, aiming for a swift transition from data readout to submission [24][36] - Partnership with Roche: Roche is a key partner in the LOTIS-7 study, providing clinical drug supply and regulatory insights [37][38] - Market Dynamics: The company highlights that the DLBCL market is evolving, with a significant portion of patients still lacking effective treatment options, positioning ZYNLONTA as a potential new standard of care [10][12] This summary encapsulates the key points discussed during the conference call, focusing on ADC Therapeutics' strategic direction, clinical trial progress, market opportunities, and financial health.