Ventyx Biosciences (NasdaqGS:VTYX) Earnings Call Presentation

VTX3232 Phase 2 Trial Results - VTX3232 demonstrated statistically significant decrease in hsCRP of up to 80% within the first week of treatment[11] - A majority of participants achieved hsCRP levels of <2 mg/L at Week 12, a critical threshold for determining CV risk[11] - VTX3232 induced rapid and durable reductions in hsCRP, with ~80% decrease after 1 week of treatment sustained through Week 12[28, 31] - In the modified analysis set, a significant proportion of participants on VTX3232 had hsCRP of <2 mg/L at Week 12[37] - VTX3232 reduces IL-6 levels below CV risk threshold while maintaining immune homeostasis[45] - VTX3232 also Reduced Lipoprotein(a), Fibrinogen, and ESR[46] - VTX3232 decreased liver inflammation at Week 12, with greater effects observed when combined with semaglutide in participants with ≥ 5% baseline liver fat[55] Safety and Tolerability - VTX3232 was safe and well-tolerated in the Phase 2 study, with rates of adverse events comparable to placebo[11, 58] - There was no evidence of increased risk of infection with VTX3232[58] Market Opportunity - There is a vast market opportunity for residual inflammation reduction in CVD, with tens of millions of CV patients globally with residual inflammatory risk[60]