Cybin (NYSEAM:CYBN) 2025 Conference Transcript

Summary of Cybin's Conference Call Company Overview - Company: Cybin - Industry: Neuropsychiatry, focusing on psychedelic-based therapeutics for mental health disorders Key Points and Arguments 1. Current Treatment Landscape: Traditional treatments for depression and anxiety primarily involve SSRIs and SNRIs, with two-thirds of patients not responding initially. Side effects include weight gain and sexual dysfunction [2][3] 2. Interventional Psychiatry Growth: The rise of interventional psychiatry practices, such as transcranial magnetic stimulation and ketamine treatments, has led to approximately 8,000 clinics in the US [2] 3. Cybin's Mission: Cybin aims to provide rapid and long-lasting relief for mood and behavioral disorders with as few as two doses per year, reducing administrative burdens for patients and providers [3] 4. Clinical Assets: Cybin has two proprietary clinical assets, CYB003 and CYB004, with over 100 granted patents and 250 pending. CYB003 has received breakthrough therapy designation from the FDA and is in a phase three program for major depressive disorder (MDD) [3][4] 5. Study Details: - CYB003: Phase two study showed a 13-14 point separation on the MADRS scale compared to placebo after a single dose, with 71% of patients in remission after two doses [10][11] - CYB004: Currently in a phase 2 proof of concept study for generalized anxiety disorder (GAD), with top-line data expected in Q1 next year [4][18] 6. Market Opportunity: MDD and GAD have around 20 million patients each in the US, with significant overlap. Cybin aims to broaden access and leverage a common commercialization platform [6][8] 7. Dosing Regimen: CYB003 requires only two doses three weeks apart, contrasting with Spravato's more frequent dosing regimen of 30-50 doses annually [24] 8. Safety Profile: Adverse events reported were mild to moderate, with no serious adverse events of suicidality noted during the 12-month follow-up [11] 9. Financial Position: Cybin has $84 million in cash as of September 30 and raised an additional $175 million in gross proceeds recently, positioning the company well for upcoming milestones [18] Additional Important Content 1. Regulatory Environment: The FDA mandates clinical supervision during dosing sessions, which is designed to mitigate risks associated with psychedelic treatments [21] 2. Commercial Strategy: Cybin's treatments are positioned as adjunctive therapies rather than first-line treatments, targeting patients who have not responded to initial therapies [26][28] 3. Potential for Combination Therapies: There is interest in exploring combination therapies with other treatments like TMS, although this has not yet been tested in studies [29] 4. Use of Proceeds: The funds raised will primarily be used for executing phase three studies and achieving data readouts next year [31]