Amgen(US:AMGN)2025-12-03 19:45Financial Data and Key Metrics Changes - The company reported a 10% revenue growth through the first nine months of the year, with product sales growth at 11% driven by a 14% volume growth [9][10] - In Q3, revenue growth was 12%, also driven by 14% volume growth, indicating strong momentum in the business [9][10] - Non-GAAP research and development expenses increased by 31% year over year in Q3, with a total of approximately $200 million spent on business development [12][28] Business Line Data and Key Metrics Changes - Repatha experienced a 30% year-over-year growth over the first nine months, with significant potential for future growth due to low penetration rates in the PCSK9 therapy market [13] - Evenity also grew by 30% year over year, holding a 60% market share in the bone builder market in the US, with a large untapped patient population [13] - Tezspire achieved 50% year-over-year growth, surpassing $1 billion in sales in the US for severe asthma [14] - The rare disease portfolio is annualizing at close to $5 billion, growing 12% year over year, with Uplizna growing 50% year over year [15] Market Data and Key Metrics Changes - The biosimilar portfolio grew by 40% year over year, now annualizing at approximately $3 billion, with cumulative revenues of $13 billion since inception [15] - The company expects increasing competitive intensity in the biosimilar market, particularly for Prolia and Xgeva, which may lead to revenue declines [43][44] Company Strategy and Development Direction - The company emphasizes innovation as its top capital allocation priority, with a focus on internal and external growth opportunities [26][28] - The company is actively engaging with the current administration regarding pricing and access policies, aiming to enhance affordability for patients [31][32] - The company is exploring opportunities in rare diseases, indicating a strong interest in expanding its portfolio in this area [48][57] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the strong momentum of the business and pipeline, highlighting the importance of volume-driven growth strategies [9][10] - The company remains optimistic about the long-term growth outlook, driven by its therapeutic areas and ongoing investments in innovation [10][12] - Management acknowledged the challenges posed by increasing competition in the biosimilar market but believes that growth drivers in other areas will offset these challenges [46] Other Important Information - The company is preparing for upcoming PDUFA dates, particularly for Uplizna, which is expected to drive further growth [15] - The company is focused on expanding its manufacturing capabilities to support the increased volume growth [29][30] Q&A Session Summary Question: What is Amgen's current position regarding agreements with the administration on manufacturing and pricing? - The company is actively engaging with the administration and has had positive relations, emphasizing its commitment to innovation and affordability for patients [31][32] Question: How does the company view the competitive landscape for Maritide in the obesity and diabetes space? - The company is confident in its ability to navigate pricing and access challenges, leveraging its experience from previous product launches [35][39] Question: What are the expectations for the denosumab biosimilar market? - The company anticipates increased competitive intensity and revenue declines for Prolia and Xgeva, but expects growth from other product lines to offset these declines [43][44] Question: How does the company plan to approach business development in rare diseases? - The company is open to various business development strategies, including licensing and acquisitions, to expand its rare disease portfolio [48][57]