Prothena (PRTA) Investor Presentation - Slideshow

15 PRX012 0.070a >67b Data represent KD values from SPRa (nM) or IC50 from ELISAb (nM). • How does binding to protofibrils compare? PRX012s Binds Aβ Protofibrils With Very High Affinity SPR Binding Kinetics Greater affinity is driven largely by a slower binding dissociation Culture time 72 hours at 37°C PRX012s facilitates concentration-dependent clearance of pyroglutamate-modified Aβ (N3pE-Aβ) at concentrations that may be relevant for PRX012 clinical exposure PRX012s Promotes Simultaneous Microglia-Mediat ...