Financial Data and Key Metrics Changes - GTV for Q4 2025 was $9.85 billion, up 14% year-over-year, marking the strongest growth in three years [21] - Orders reached 89.5 million, up 16% year-over-year, while average order value decreased by 1% year-over-year [21] - GAAP net income was $81 million, down 46% year-over-year, primarily due to higher G&A expenses related to non-recurring legal matters [23] - Adjusted EBITDA grew 20% year-over-year to $303 million, with operating cash flow of $184 million, also up 20% year-over-year [23] Business Line Data and Key Metrics Changes - Advertising and other revenue grew 10% year-over-year, driven by strong GTV performance and onboarding of more Carrot Ads partners [22] - Transaction revenue grew 13% year-over-year, representing 7.1% of GTV, which was flat year-over-year [21] - The number of brands advertising on Instacart increased to over 9,000, up from 7,000 a year ago [46] Market Data and Key Metrics Changes - Instacart's marketplace now includes more than 2,200 retail banners across nearly 100,000 locations [8] - The company reported that approximately 10 million unique customers placed at least one order in December 2025, a new high [18] Company Strategy and Development Direction - The company aims to be the trusted platform for all grocery needs, leveraging technology for grocers and creating an advertising ecosystem for brands [8] - Instacart is focusing on expanding its enterprise partnerships, which include deeper integrations and shared planning with retailers [9] - The company is investing in AI to enhance operational efficiency and improve customer experiences [14][16] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to drive durable, profitable growth, citing strong momentum and a favorable operating environment [6][19] - The company anticipates GTV for Q1 2026 to range between $10.125 billion and $10.275 billion, representing year-over-year growth of 11%-13% [24] - Management noted that competition in the grocery e-commerce space is not negatively impacting Instacart's growth, as the market opportunity remains large [39] Other Important Information - The company will transition to an annual shareholder letter starting Q1 2026, aiming for a more holistic assessment of its long-term strategy [3] - Instacart repurchased $1.4 billion of shares in 2025, including $1.1 billion in Q4 alone [24] Q&A Session Summary Question: How should we think about the scope of the opportunity in marketplace and enterprise adoption? - Management highlighted that both marketplace and enterprise sides are growing, with enterprise providing deeper strategic conversations and technical integrations with retailers [30] Question: What has driven the acceleration in business metrics? - Management noted strong user growth and engagement, with record customer retention and increased spend per customer [36] Question: Can you discuss the stronger-than-expected advertising performance? - Management attributed the strong advertising performance to GTV growth and a diversification strategy across supply and demand [46] Question: How are you approaching international growth? - Management expressed excitement about international markets, noting that many retailers are still underdeveloped in e-commerce [50] Question: What is the status of Instacart Plus adoption? - Management reported that Instacart Plus continues to represent the majority of GTV and orders, with growing engagement and retention among members [67]

Financial Data and Key Metrics Changes - The company reported gross revenues of BRL 19.5 billion in 2025, an 8% increase year-over-year [9][33] - Adjusted net income for Q4 2025 was BRL 1.3 billion, and BRL 5.2 billion for the full year, representing a 15% expansion year-over-year [10][38] - The return on equity (ROE) reached 23.9% in 2025, a 94 basis points increase compared to 2024 [11][40] - The year-end BIS ratio was 20.4%, indicating a strong capital position [11][41] Business Line Data and Key Metrics Changes - Retail revenues totaled BRL 3.9 billion in Q4 2025, up 8% year-over-year, and BRL 14.6 billion for the full year, also an 8% increase [33][34] - Corporate and issuer services revenue reached BRL 895 million in Q4 2025, a 49% increase year-over-year, and BRL 2.7 billion for the full year, up 19% compared to 2024 [35][36] - The wholesale bank has become a key pillar of the company's strategy, integrating investment banking and institutional access [27][28] Market Data and Key Metrics Changes - Total client assets, including AUM and AUA, reached BRL 2.1 trillion, representing a 22% growth year-over-year [21] - Retail net new money was BRL 20 billion, while corporate and institutional net new money totaled BRL 12 billion, amounting to BRL 32 billion for the period [21][22] - The company faced challenges with small and medium enterprises withdrawing BRL 3 billion in investments, but individual client inflows totaled BRL 23 billion [22] Company Strategy and Development Direction - The company aims to become Brazil's leading investment platform by 2033, focusing on market share and democratizing wealth planning for retail clients [51][52] - A third wave of strategy is being implemented to enhance service models and client segmentation, moving away from a product-driven approach [52][54] - Continued investments in technology and advisor training are expected to drive growth and improve service quality [18][45] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in capturing future opportunities despite a challenging environment for 2026 [7][22] - The company is focused on maintaining strong returns while expanding its credit offerings and addressing the needs of small and medium enterprises [29][45] - Concerns were raised regarding recent irregularities in the financial system, with a commitment to support structural improvements [46][48] Other Important Information - The company returned BRL 2.4 billion to shareholders through dividends and buybacks in 2025 [39] - Adjusted EPS for Q4 was BRL 2.56, growing 15% year-over-year, and for the full year, it reached BRL 9.81, an 18% increase [40][41] - The company is launching new products, including a proprietary dollar-backed stablecoin and expanding its insurance offerings [23][24] Q&A Session Summary Question: Ambition to become Brazil's leading investment platform by 2033 - The company aims for market share leadership by 2033, with plans indicating the ability to achieve this in seven years through democratizing wealth planning and enhancing service models [51][52] Question: Impact of entry into the controlling group - The CEO stated that there is no change in management style or operations, emphasizing stronger alignment among executives [54] Question: Impact of CVM's recommendation on RLP business - Management views the removal of caps on orders as positive for the RLP business, enhancing market-making capabilities [60][62] Question: Tax increases and their relation to revenue mix - The CFO clarified that the increase in taxes is due to the revenue mix, particularly from corporate and issuer services, and not related to structural changes [63][64] Question: Strategy to capture volumes from Banco Master reimbursements - The company is seeing a significant inflow from Banco Master, retaining over 85% of the funds, and will disclose net new money figures in Q1 [68][69]

Financial Data and Key Metrics Changes - In Q4 2025, total revenue grew 14% year-over-year to $44.6 million, with a sequential increase of 16% [7][27] - For the full year 2025, total revenue reached $160 million, representing a 4% growth over 2024 [7][30] - Non-GAAP gross margin improved to 40% in Q4 2025, up from 31% in Q4 2024, and for the full year, it was also 40%, compared to 33% in 2024 [31][24] - Non-GAAP operating expenses decreased to $56.2 million in Q4 2025, down 18% year-over-year, and for the full year, they were $229.9 million, down from $289.2 million in 2024 [32][24] - Cash burn improved from $214 million in 2023 to $105 million in 2025, with approximately $280 million in cash and investments at year-end [25][34] Business Line Data and Key Metrics Changes - Consumable revenue in Q4 2025 increased 15% year-over-year to $21.6 million, driven by an increase in the installed base and consistent system utilization [27][28] - Instrument revenue rose 13% in Q4 to $17.3 million, primarily due to increased shipments of Vega systems [28] - For the full year 2025, consumables revenue increased 16% to $82 million, while instrument revenue decreased 18% to $53.8 million [30] Market Data and Key Metrics Changes - Revenue from the Americas increased 3% to $20.7 million in Q4 2025, while Asia Pacific revenue rose 4% to $9.3 million, and EMEA revenue surged 45% to $14.6 million [29][10] - EMEA's strong growth was attributed to increased Vega instrument shipments and higher Revio consumables as clinical customers transitioned from pilot testing to broader adoption [11][29] Company Strategy and Development Direction - The company aims to enhance the economics of HiFi sequencing through the launch of SparkNex and multi-use smart cells, targeting increased market penetration [37] - Focus areas include accelerating clinical adoption in rare disease, oncology, and carrier screening, as well as enabling population-scale sequencing studies [37] - The company plans to leverage AI to unlock biological insights from multi-omic HiFi data [37] Management's Comments on Operating Environment and Future Outlook - Management anticipates continued growth in clinical markets, particularly in rare disease and whole genome sequencing, despite a challenging academic funding environment [11][54] - The outlook for 2026 projects revenue between $165 million and $180 million, representing approximately 8% growth at the midpoint [34] - Management expects non-GAAP gross margin to improve by 100-400 basis points in 2026, driven by a higher consumables mix and the introduction of SparkNex [35] Other Important Information - The company sold its short-read sequencing assets for net proceeds of approximately $48 million, strengthening its balance sheet and extending its cash runway [26] - The company is committed to supporting existing customers during the transition period following the divestment of short-read assets [26] Q&A Session Summary Question: What should we expect for Revio pull-through and consumables growth? - Management expects SparkNex to lower sample costs, likely increasing utilization and expanding market share, while maintaining pull-through in the range of $225K-$250K [41][43] Question: What is the outlook for clinical growth outside the U.S.? - Management sees strong growth in clinical markets, particularly in EMEA, with significant movement from pilot phases to production [53] Question: Where are the biggest opportunities for OpEx reduction? - Management plans to focus on managing G&A expenses and R&D while continuing to reduce production costs through insourcing [66][68] Question: What impact will the short-read divestment have on costs? - Management indicated that while there won't be substantial additional costs taken out immediately, the divestment will provide a tailwind to gross margin over time [72] Question: How does long-read sequencing compare to standard care in terms of cost? - Long-read sequencing is expected to provide better diagnostic yield, faster turnaround times, and lower overall costs by consolidating multiple tests into one [74]

Financial Data and Key Metrics Changes - Recurring gross profits increased by 33% in 2025, with adjusted EBITDA margins expanding to 34% [5][26] - Annual recurring revenue (ARR) grew by 26%, reaching over $2 billion, with payment volume hitting $195 billion [26] - GAAP operating income rose to $292 million from $16 million a year ago, driven by strong adjusted EBITDA and effective management of stock-based compensation [27][30] Business Line Data and Key Metrics Changes - SaaS ARR and subscription revenue each grew by 28% year-over-year, with SaaS ARPU in the core growing even faster than total SaaS ARPU [29] - Subscription gross profit increased by 33%, with SaaS gross margin expanding by 300 basis points year-over-year to 80% in Q4 [30] - Payments ARR grew by 24%, while fintech gross profit increased by 25% in Q4 [30] Market Data and Key Metrics Changes - The company added a record 30,000 net locations in 2025, ending the year with 164,000 locations [26] - The net retention rate remained healthy at 109% in 2025, supported by upsell and location expansion from existing customers [30] - The company powers 20% of SMB and mid-market restaurants in the U.S., nearly doubling over the past three years [8] Company Strategy and Development Direction - The company aims to double market share in its core U.S. SMB and mid-market restaurants, while also expanding into new markets [8][12] - Investments will focus on product differentiation, particularly in AI and customer support, to enhance operational efficiency [10][21] - The company plans to launch new products, including a drive-thru solution, to capture additional market segments [14][73] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in sustaining high growth for the next 5-10 years, driven by strong customer signals and market opportunities [38] - The company anticipates a 20%-22% growth in recurring gross profit streams for 2026, with adjusted EBITDA expected to be between $775 million and $795 million [36] - Management highlighted the importance of disciplined capital allocation while investing in high-priority initiatives [24][35] Other Important Information - The company has repurchased approximately 8 million shares for $235 million since the inception of its buyback authorization in 2024 [35] - The company is experiencing cost pressures from higher memory chip costs, which are expected to impact margins in the second half of 2026 [36][37] Q&A Session Summary Question: SaaS ARR per location and enterprise metrics - Management confirmed confidence in mid-single-digit SaaS ARPU growth for 2026, with core SaaS ARPU growing faster than total company metrics [41][44] - Enterprise sales cycles are different, and management evaluates them on a deal-by-deal basis, focusing on total ARR [44] Question: Net adds and new verticals - Management indicated that net add growth in 2026 is expected to be higher than in 2025, with a similar pattern of growth from core and new towns [48][50] Question: AI disruption and competitive landscape - Management views AI as an opportunity to enhance the platform rather than a threat, emphasizing the unique value Toast provides through its integrated solutions [51][56] Question: R&D investment and margin framework - Management confirmed that the margin framework allows for increased R&D investment to capitalize on AI opportunities while targeting long-term margins of 40% [60][62] Question: Drive-through product rollout - The company plans to launch a drive-through product this year, which will significantly expand its market reach [73][74]

Pacific Biosciences of California (NasdaqGS:PACB) Q4 2025 Earnings call February 12, 2026 05:00 PM ET Company ParticipantsChristian Henry - CEODan Brennan - Managing DirectorJim Gibson - CFOKelly Guru - Director of Investors RelationsConference Call ParticipantsDavid Westenberg - Managing Director and Equity Research AnalystDoug Shenko - Senior AnalystJack Meehan - Equity Research AnalystKyle Mixon - Equity Research AnalystMason Carrico - Equity Research AnalystSubbu Nambi - Managing Director and Healthcare ...

Electrovaya (NasdaqCM:ELVA) Q1 2026 Earnings call February 12, 2026 05:00 PM ET Company ParticipantsColin Rusch - Managing Director and Head of Sustainable Growth and Resource Optimization ResearchDaniel Magder - Managing Director of Investment BankingGraham Tanaka - PresidentJohn Gibson - CFORaj DasGupta - CEOConference Call ParticipantsAmit Dayal - Managing Director and Senior Technology AnalystCraig Irwin - Managing Director and Senior Research AnalystEric Stine - Senior Research AnalystJeffrey Campbell ...

Financial Performance - Total revenue decreased approximately $3 million or 2.7% to approximately $108.5 million for the quarter ended December 31, 2025, compared to revenue of approximately $111.5 million in the prior year period [4] - Operating income increased approximately $2.7 million or 352.9% to $3.5 million for the first quarter, compared with operating income of approximately $800,000 in the prior year period [9] - Adjusted EBITDA for the first quarter was approximately $7.8 million, an increase of approximately $2 million or 35.7% compared to $5.7 million in the prior year period [10] Business Segment Performance - Retail-Flooring segment revenue for the first quarter was approximately $25.3 million, down $6.4 million or 20.2% compared to $31.7 million in the prior year period, primarily due to changes in store footprint and softness in the housing market [5] - Flooring Manufacturing segment revenue for the first quarter was approximately $28.9 million, a decrease of approximately $300,000 or 1.1% compared to approximately $29.2 million in the prior year period [6] - Steel Manufacturing segment revenue for the first quarter was approximately $31.9 million, a decrease of approximately $1.4 million or 4.3% compared to approximately $33.3 million in the prior year period [7] Market Conditions - The decline in revenue was primarily attributable to a $7.1 million decline in the Retail-Flooring and Steel Manufacturing segments, partially offset by a $4.1 million increase in the Retail-Entertainment and Flooring Manufacturing segments [4] - The company experienced sustained softness in new home construction and home refurbishment markets, which continued to weigh on the retail flooring segment [3] Company Strategy and Industry Competition - The company is rolling out a comprehensive strategy to integrate AI across the business units to modernize operations and improve efficiency [11] - The integration of AI alongside robotics and data analytics aims to reinforce cost discipline that supports the long-term strategy [12] Management Commentary on Operating Environment and Future Outlook - Management noted that despite a challenging housing market backdrop, the company delivered a solid first quarter marked by meaningful operating improvements across the businesses [11] - The company successfully refinanced one of its credit facilities in the steel manufacturing segment, strengthening its balance sheet and enhancing its ability to support future growth [3] Other Important Information - Gross profit was approximately $35.4 million for the first quarter, essentially unchanged compared to the prior year period, but gross margin increased by 90 basis points to 32.6% [8] - General and administrative expense decreased approximately $2.2 million or 7.4% to approximately $27.8 million, driven primarily by targeted cost reduction initiatives [9] - Total cash availability at the end of the first quarter was $38.7 million, consisting of cash on hand of $15.1 million and availability under various lines of credit of $23.6 million [11] Q&A Session Summary Question: Are there any questions from the participants? - There were no questions from the participants during the Q&A session [13]

Financial Data and Key Metrics Changes - Revenue for Q1 2026 was $15.5 million, a 39% increase from $11.1 million in the prior year [12] - Gross margins improved to 32.9%, up 240 basis points from 30.5% in the previous year [12] - Operating profit increased to $1.4 million from an operating loss of $0.2 million in the prior year [13] - Net profit for the quarter was $1 million, a significant increase from a net loss of $0.4 million in the prior year [14] - Adjusted EBITDA was $2 million, a 265% increase from $0.5 million in the prior year [15] - Positive cash flow from operations was $1.7 million, compared to cash used in operating activities of $0.3 million in the prior year [15] - Total debt increased to $27.3 million from $15.3 million in the prior year, with working capital debt decreasing to $10.9 million [16] Business Line Data and Key Metrics Changes - The core material handling vertical showed strong progress, with new OEM integrated high-voltage battery systems scheduled for commercial deliveries in March 2026 [7] - Deliveries were made to a global defense contractor for a new vehicle platform, indicating growth in the defense sector [7] - Robotics is viewed as a high-growth vertical, with commercial deliveries of modular 48-volt battery systems initiated in January [8] Market Data and Key Metrics Changes - A Japanese subsidiary was established to support growing demands in Japan and the Asia Pacific region [8] - The company is seeing encouraging interest across multiple verticals, including automation, robotics, and energy storage for data centers [8] Company Strategy and Development Direction - The company aims to expand manufacturing capacity in Jamestown, New York, and develop next-generation products and technologies [7] - The focus is on maintaining profitability while exploring new market verticals and enhancing product offerings [18] - The company plans to launch new products for Class Three material handling vehicles and next-generation software solutions at MODEX 2026 [10] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about maintaining strong margins and profitability into fiscal 2026 and beyond [14] - The company reaffirmed its revenue guidance of 30% growth for fiscal 2026, despite historical seasonality in Q1 [18] - Management highlighted the potential for increased revenue from airport ground support equipment and other new product developments [65] Other Important Information - The company raised gross proceeds of $28 million from an equity issuance, enhancing its financial foundation for expansion [16] - The company is transitioning to a U.S. domestic filer under SEC rules, which may broaden its investor base and improve trading liquidity [18][19] Q&A Session Summary Question: Update on customer sales funnel velocity - Management indicated that large Fortune 100 and 500 companies dominate the customer base, with good visibility on demand for the fiscal year [24] Question: Progress on stationary storage project pilots - Management confirmed pilots are scheduled, including a government-backed project, with discussions ongoing for energy storage systems [28] Question: Expected revenue contribution from defense sector - Management expects robotics to be the second-largest revenue driver, with defense also contributing meaningfully [32] Question: CapEx outlook and workforce hiring for Jamestown - Management anticipates significant CapEx spending in Q2 and Q3, with ongoing hiring of experienced personnel for the Jamestown facility [53][54] Question: Revenue contribution from Jamestown facility - Cell manufacturing is expected to start contributing in fiscal 2027, while battery systems may generate revenue in Q4 of fiscal 2026 [57] Question: Impact of semiconductor costs on margins - Management noted that input material price variations have a nuanced impact on margins, with no significant issues reported [84][87] Question: Military spending contribution to revenue - Management indicated that defense margins are expected to be higher, but scaling in volume may be slow due to qualification processes [89]

Financial Data and Key Metrics Changes - In 2025, the company closed $4.3 billion in new transactions, an increase of 87% compared to 2024, with a growing pipeline from over $5.5 billion at the end of Q1 to over $6.5 billion at the end of 2025 [6][10] - Adjusted EPS growth was 10.2% in 2025, reaching $2.70 per share, while adjusted recurring net investment income increased by 25% to $362 million [17][18] - Adjusted ROE rose by 70 basis points to 13.4% in 2025, with incremental ROE exceeding 19% [18][13] Business Line Data and Key Metrics Changes - The company reported a significant increase in investment volumes, with $3.6 billion retained on the balance sheet, up approximately 140% year-over-year from $1.5 billion in 2024 [9] - The residential solar and storage sector continues to thrive, with a joint venture totaling $500 million with Sunrun, reflecting strong demand for affordable and resilient energy solutions [14] - The grid-connected business is benefiting from a growing renewables pipeline, primarily driven by solar and storage, which now exceeds $230 billion [11] Market Data and Key Metrics Changes - The underlying demand for power and the cost-effectiveness of the company's asset classes have created an attractive investing environment, with PPA rates increasing more than 40% over the past three years [10] - Renewables now comprise 99% of the projected capacity additions in 2026, indicating a strong market trend towards sustainable energy [11] Company Strategy and Development Direction - The company aims to enhance capital efficiency and profitability, with a focus on recycling capital to reduce the payout ratio to below 50% by 2028 and below 40% by 2030 [16] - The strategy includes expanding equity commitments in CCH1 and leveraging new funding sources to optimize returns and reduce reliance on new equity issuance [22][23] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the ongoing ability to achieve profitability objectives, with a three-year guidance extending to 2028, expecting adjusted EPS in the range of $3.50-$3.60 [15][16] - The company noted that while 2026 guidance is not explicitly provided, the strong pipeline and transaction closings suggest continued growth [32] Other Important Information - The company achieved a record of 1.7 million metric tons of avoided annual CO emissions from new investments in 2025, contributing to a total of 10 million metric tons avoided to date [24] - Significant investments in talent and technology have been made to position the business for further scale, exceeding $16 billion in managed assets [25] Q&A Session Summary Question: Outlook for 2028 and growth above 10% CAGR - Management highlighted the importance of management credibility and pathways to exceed guidance through increased volume and better yields [28][29] Question: Immediate outlook for 2026 - Management indicated that while they do not expect to reach $4.3 billion in transactions again, they anticipate being higher than historical closings [33] Question: Change in guidance strategy - The switch to nominal EPS guidance allows for more precise adjustments in future quarters, reflecting increased confidence in the business [39] Question: Impact of PPA renegotiations on earnings - Management noted that positive renegotiations of PPAs could lead to higher EPS than current guidance, as these renegotiations improve long-term cash flows [73][76] Question: Approach to data center financing - Management is evaluating potential roles in the data center ecosystem, recognizing the indirect involvement through demand-driven projects [81][82]

Financial Data and Key Metrics Changes - For 2025, the company reported total revenue of $673 million, representing a 20% growth over 2024, exceeding the upper end of guidance [11] - The net loss for the year was $575 million, or $5.83 per share, with cash, cash equivalents, and marketable securities totaling $738 million as of December 31 [12] - Guidance for 2026 expects total revenue between $730 million and $760 million, reflecting an 8%-13% growth over 2025 [12][13] Business Line Data and Key Metrics Changes - Crysvita contributed $481 million in revenue, with a 17% growth over 2024, while Dojolvi generated $96 million, representing a 9% growth [11] - Evkeeza saw significant growth of 84% over 2024, contributing $59 million, and Mepsevii contributed $37 million [11] - The company anticipates Crysvita revenue in 2026 to be between $500 million and $520 million, with Dojolvi expected to generate between $100 million and $110 million [13] Market Data and Key Metrics Changes - The commercial business delivered a significant 20% year-over-year growth in 2025, with treatments now available in over 35 countries [8] - In Latin America, Crysvita's business is anchored in Brazil and Argentina, with solid reimbursement growth in Mexico and Colombia [17] - Dojolvi continues to grow steadily in the U.S. and EMEA, with recent regulatory wins in Kuwait and the U.K. [18] Company Strategy and Development Direction - The company is focused on achieving profitability by 2027 through a strategic restructuring plan that includes a 10% workforce reduction and realignment of resources towards high-impact opportunities [9][10] - The company aims to launch three additional treatments over the next two years while continuing to grow its existing commercial products [10][24] - The strategic restructuring will allow the company to maintain a diversified pipeline, not solely focused on gene therapy [54] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the upcoming year, highlighting key inflection points with potential approvals in MPS IIIA and glycogen storage disease type Ia, as well as pivotal data readouts in Angelman syndrome [4][20] - The management acknowledged the challenges posed by the FDA's incomplete response letter regarding UX111 but emphasized their commitment to providing the necessary documentation for resubmission [7][52] - The company remains optimistic about its ability to deliver meaningful growth and reach profitability, supported by a strong commercial infrastructure and ongoing product launches [20][42] Other Important Information - The company has implemented a strategic restructuring plan to reduce operating expenses and align resources with high-impact opportunities, aiming for profitability in 2027 [9][10] - The company expects R&D and SG&A expenses to decrease significantly in 2027, driven by the completion of clinical studies and reduced early-stage research efforts [15] Q&A Session Summary Question: Can you explain the choice of cognition as the primary endpoint for the Angelman study? - The decision was based on the fundamental nature of cognition and its interrelation with communication, with a focus on a broader assessment through the Multidomain Responder Index [27][28] Question: What is the baseline profile of patients in the Angelman study? - The baseline data from the phase 2 trial is reflective of the phase 3 program, and the company is comfortable with the comparability of the cohorts [33] Question: How does the company plan to achieve profitability in 2027? - The pathway to profitability includes continued growth from existing products, cost reductions, and contributions from upcoming launches [38][40] Question: What is the status of the DTX-301 program? - The DTX-301 program is ongoing, with data expected to be released this year [49] Question: Can you provide an update on the UX111 program and the IRL received? - The company is preparing to provide comprehensive documentation to address the IRL issues and is committed to resubmitting the BLA [52][53]