Financial Performance - The company achieved a 4% increase in sales, reaching $13.884 billion, compared to the prior year[12] - Adjusted Operating Income (AOI) increased by 3% year-over-year to $505 million[12] - Adjusted EPS increased by 5% year-over-year to $0.91 per share[12] - The company's year-to-date (YTD) free cash flow reached $929 million[31] Segment Highlights - Prepared Foods saw a sales increase of 3.4% to $2.515 billion and an AOI increase of $43 million[14] - Chicken segment sales increased by 3.5% to $4.220 billion and AOI increased by $38 million[19] - Pork segment sales increased by 3% to $1.506 billion and AOI increased by $14 million[27] - Beef segment sales increased by 6.9% to $5.603 billion, but experienced an AOI loss of $151 million, a decrease of $82 million[23] Financial Position - The company's leverage ratio improved year-over-year and quarter-over-quarter, reaching 2.1x[33] - Capital expenditures for the quarter totaled $227 million[34] FY25 Guidance - The company projects sales growth of 2%-3% for fiscal year 2025[37] - Total AOI is projected to be between $2.1 billion and $2.3 billion[37]

Q2 2025 Financial Performance - Revenue reached $1,109 million, an 11% reported growth and 9% organic growth[1] - Operating profit was $373 million, representing 34% of revenue[1] - Diluted earnings per share (EPS) grew by 49% to $3.63, with a comparable growth of 17%[1] - CAG (Companion Animal Group) Diagnostics Recurring revenue reported growth of 9% and organic growth of 7%, with a 730 bps reported and 130 bps comparable year-over-year change in basis points[1] Segment Revenue Growth - CAG revenue was $1,022 million, with 11% reported growth and 10% organic growth[1] - Water revenue reached $51 million, showing 9% reported growth and 8% organic growth[1] - LPD (Livestock, Poultry and Dairy) revenue was $32 million, with 5% reported growth and 3% organic growth[1] 2025 Financial Outlook - Revenue is projected to be between $4,205 million and $4,280 million, representing 7.7% to 9.7% reported growth and 7.0% to 9.0% organic growth[6,7] - Operating margin is expected to be 31.3% to 31.6%, with a reported margin expansion of 240 to 270 bps and a comparable margin expansion of 50 to 80 bps[6,7] - EPS is forecasted to be $12.40 to $12.76, indicating 16% to 20% reported growth and 9% to 13% comparable growth[6,7] U S Companion Animal Practice Growth (As of June 30, 2025) - U S companion animal practices experienced a 6.1% year-over-year growth in total practice revenue[9] - Total visits to U S companion animal practices decreased by 3.4% year-over-year[9] - Clinical visits decreased by 2.5%, while non-wellness visits decreased by 2.7% year-over-year[9] - Diagnostic revenue per clinical visit increased by 4.5% year-over-year[14]

Financial Performance - Revenue increased by 22.7% year-over-year in Q2 2025[10] - Adjusted EBITDA grew by 59.5% year-over-year in Q2 2025[10] - Organic Revenue increased by 0.4% year-over-year[10] - The company repurchased approximately 1.6 million shares of its common stock for $6.9 million at an average price of $4.24 per share in Q2 2025[10, 37] - Emerald reaffirms full year 2025 revenue guidance in the range of $450 million to $460 million and Adjusted EBITDA in the range of $120 million to $125 million[10, 11] Business Segments - Connections segment accounted for approximately 90% of FY 2024 revenue[14, 15] - Content segment accounted for approximately 5% of FY 2024 revenue[14, 19] - Commerce segment accounted for approximately 5% of FY 2024 revenue[14, 19] Market and Growth - B2B US Marketing spend for events and sponsorships is expected to grow by a CAGR of +7% through 2030[25, 28] - The company estimates a total global addressable market of $20 billion[11] Capital Allocation - The company targets a long-term net leverage ratio between 20x and 30x[48] - The company declared a dividend of $0015 per share for the quarter ending September 30 2025[10, 48]

Financial Performance Highlights - SiriusPoint's Gross Premiums Written (GPW) increased by 10% year-over-year in Q2 2025[19, 47] - The Core Combined Ratio improved by 38 percentage points to 895% in Q2 2025[19] - Underlying Earnings Per Share (EPS) rose by 120% year-over-year to $066 in Q2 2025[19, 47] - Book Value Per Share (BVPS) excluding Accumulated Other Comprehensive Income (AOCI) grew by 4% in Q2 2025 and 10% year-to-date, reaching $1564[19] - The Underlying Return on Equity (ROE) was 170% in Q2 2025, contributing to 154% at HY 2025[19] Segment Results - The Insurance & Services segment experienced a 14% increase in Gross Premiums Written (GPW) in Q2 2025, resulting in an 18% growth for HY 2025[63] - The Reinsurance segment's Gross Premiums Written (GPW) grew by 5% in Q2 2025, contributing to a 2% growth year-to-date[67] Capital and Balance Sheet - The BSCR ratio is estimated at 223% in Q2 2025[13, 19] - The debt-to-capital ratio decreased slightly to 244% at Q2 2025[97, 102] - Common shareholders' equity increased 4% to $19 billion[50]

Q2 2025 Financial Performance - Revenue decreased by $3.3 million, a -0.4% decline[7] - Organic revenue declined by -7.0%, with BSI down -7.2% and BEST down -4.8%[7] - Non-GAAP EPS was $0.32, a decrease of -38.5%, including a $0.06 FX headwind[7, 39] - Non-GAAP operating margin decreased to 9.0%, down -480 bps[7] H1 2025 Financial Performance - Revenue increased by $76.4 million, a 5.0% increase[9] - Organic revenue declined by -2.3%, with BSI down -1.4% and BEST down -11.5%[9] - Acquisition contributed +6.5% to revenue[9] - Non-GAAP EPS was $0.78, a decrease of -25.7%, including a $0.08 FX headwind[9, 42] - Non-GAAP operating margin decreased to 10.9%, down -300 bps[9] FY 2025 Outlook - Revenue is projected to be between $3.43 billion and $3.50 billion, representing a growth of +2% to +4%[48] - Organic revenue is expected to decline by -2% to -4%[48] - M&A is expected to contribute approximately +3.5% to revenue[48] - Non-GAAP EPS is projected to be between $1.95 and $2.05, a decline of -15% to -19%[48]

Financial Performance & VYJUVEK Launch - VYJUVEK revenue since launch exceeds $525 million[8] - Second quarter 2025 product revenue reached $96 million, compared to $70.3 million in the second quarter of 2024[43] - Gross margin in the second quarter was 93%[10, 43] - Gross to net in the second quarter was 17%[10] VYJUVEK Expansion & Approvals - VYJUVEK received approval in Japan for DEB patients from birth, with launch expected in the fourth quarter of 2025[11, 14] - Over 575 reimbursement approvals in the U S[10] - U S compliance to weekly therapy while on drug at 82% as of end of 2Q 2025[10] - European launch is on track for later this quarter, with over 575 identified DEB patients in Germany and France[15, 16] Pipeline Development - 36% objective response rate was observed with KB707 monotherapy in advanced NSCLC patients[22] - 40% AAT positive cells after KB408[26] - Functional AAT delivery to the lungs was confirmed in the third patient dosed with KB408, showing a 79.3% reduction in free neutrophil elastase in ELF after a single dose[25, 26] Financial Guidance - Non-GAAP R&D and SG&A expense guidance for the full year 2025 is $150 million to $175 million[44]

Vormatrigine Efficacy and Development - RADIANT study showed a 56.3% overall median seizure reduction with vormatrigine[21] - A significant proportion of patients achieved ≥50% seizure reduction, independent of baseline seizure burden[26] - Vormatrigine is being developed as a potential stand-alone agent, with POWER3 study expected to initiate in 1H 2026[40, 42] - POWER2 study is staged to initiate this quarter and complete enrollment in 2H 2026, with a sample size of approximately 400 patients[37] Safety and Tolerability - In the RADIANT study, 59% of patients experienced ≥1 treatment-emergent adverse event (TEAE) with vormatrigine 30 mg[33] - 4.9% of patients experienced severe adverse events (AEs) and serious AEs (SAEs) with vormatrigine 30 mg[33] - 1.6% of patients experienced a related SAE with vormatrigine 30 mg[33] Pipeline and Catalysts - The company has assets in late stage development, with clinical readouts expected in the next 4 quarters[7] - Topline results for the RADIANT Phase 2 study are expected by mid-2025[8] - Finalization of the POWER1 Phase 2/3 study is expected in Q4 2025[8] - Candidate declaration for PRAX-100 (SCN2A LoF) is expected by mid-2025, and for PRAX-080 (PCDH19) and PRAX-090 (SYNGAP1) by year-end 2025[8] Financial Position - The company has a cash runway into 2028[7]

Financial Performance & Guidance - BioCryst's Q2 2025 was strong, driven by increased ORLADEYO demand[14] - ORLADEYO revenue is expected to meet the previous guidance range of $580-600 million for FY25, even excluding Q4 2025 EU revenue[16] - The company anticipates achieving full-year operating profit in 2026 and positive net income & cash flows in 2026+[58] - Cash, cash equivalents, restricted cash & investments totaled $287 million as of June 30, 2025[63] - The company paid down $50 million of its senior credit facility in July 2025[62] ORLADEYO & Market Dynamics - Market research indicates a growing patient preference for oral administration of HAE long-term prophylaxis (LTP) since 2023[17] - Monte Carlo simulation projects ORLADEYO reaching a steady state of over 2,000 patients in the US by 2028[25] - ORLADEYO revenue advances to royalty-free tier (>$550M)[61] - The blended royalty rate for ORLADEYO is expected to decline to approximately 4% at peak sales once OMERS reaches its cap[67] Pipeline Development - The PDUFA target date for the pediatric NDA for ORLADEYO is December 12, 2025[32] - An IND has been cleared by the FDA for BCX17725, a targeted KLK5 inhibitor for treating Netherton syndrome (NS)[37]

Q2 2025 Financial Performance - Q2 2025 revenue reached $771 million, reflecting a 9% increase as reported and an 8% increase in constant currency[11] - Constant currency recurring revenue grew by 11%[11] - Constant currency instrument revenue grew by 4%[11] - Q2 2025 Non-GAAP EPS was $2.95, a 12% increase[11] - Waters division revenue grew by 10% in constant currency, while TA division revenue decreased by 6% in constant currency[33] Regional Performance (Constant Currency) - Asia experienced a 14% revenue growth, with China also at 14%[13] - Americas saw a 2% revenue growth[13] - Europe showed an 8% revenue growth[13] Full Year and Q3 2025 Guidance - The company projects full-year 2025 constant currency revenue growth between 5% and 7%[20] - The company projects Q3 2025 constant currency revenue growth between 4% and 7%[20] - Full-year 2025 Non-GAAP EPS is projected to be between $12.95 and $13.05[20] - Q3 2025 Non-GAAP EPS is projected to be between $3.15 and $3.25[20] Biosciences & Diagnostic Solutions Synergies - The company anticipates $200 million in cost synergies by year 3[26] - The company anticipates $290 million in revenue synergies by year 5[26]

Financial Performance & Projections - Axsome reported Net Product Revenue of $150 million in 2Q 2025, a 72% increase compared to $872 million in 2Q 2024 [21] - AUVELITY Net Product Sales reached $1196 million in 2Q 2025, an 84% increase from $650 million in 2Q 2024 [21] - SUNOSI Net Product Revenue was $30 million in 2Q 2025, a 40% increase compared to $221 million in 2Q 2024 [21] - SYMBRAVO Net Product Sales were $04 million in 2Q 2025 [21] - The company estimates a combined peak sales potential of $165 billion across its differentiated portfolio [16] Clinical & Regulatory Milestones - The company commercially launched SYMBRAVO in the US in June 2025 [20] - Positive topline results were achieved from the EMERGE Phase 3 trial of SYMBRAVO in oral CGRP non-responders in 1Q 2025 [20] - Positive topline results were achieved from the FOCUS Phase 3 trial of solriamfetol in ADHD in adults in 1Q 2025 [20] - Topline results were achieved from the PARADIGM Phase 3 trial of solriamfetol in MDD in 1Q 2025 [20] - An sNDA submission for AXS-05 in Alzheimer's disease agitation is expected in 3Q 2025 [20] - An NDA submission for AXS-12 in narcolepsy is expected in 4Q 2025 [20] Market & Pipeline - The company is developing new indications across approved products and has Phase 3 development programs ongoing [13] - The company plans to initiate a Phase 3 trial of solriamfetol in ADHD in pediatric patients in 4Q 2025 [20] - The company plans to initiate a Phase 3 trial of solriamfetol in MDD with EDS in 4Q 2025 [20] - The company plans to initiate a Phase 3 trial of AXS-14 in fibromyalgia in 4Q 2025 [20] - The company plans to initiate a Phase 2/3 trial of AXS-05 in smoking cessation in 4Q 2025 [20]