Merck (OTCPK:MKGA.F) FY Conference January 12, 2026 02:15 PM ET Speaker0to the 44th J.P. Morgan Healthcare Conference. I'm Richard Vosser, European Pharma Analyst with J.P. Morgan. It's my great pleasure to host and introduce the CEO, Belén Garijo, from Merck KGaA, Darmstadt, Germany, and their presentation today at the conference. Just before I hand over to Belén, just a few housekeeping remarks. If you want to ask a question, put your hand up and we can take it in the room, or you can put your questions o ...

Apellis Pharmaceuticals (NasdaqGS:APLS) FY Conference January 12, 2026 02:15 PM ET Company ParticipantsCedric Francois - CEOVolker Wendel - Founder and CEOTim Sullivan - CFOConference Call ParticipantsNone - AnalystAnupam Rama - Senior Biotech AnalystAnupam RamaAlrighty, let's get started. Thanks, everyone, for joining. This is the 44th Annual JPMorgan Healthcare Conference. My name is Anupam Rama. I'm one of the senior biotech analysts here at JPMorgan. I'm joined by my squad: Priyanka Grover, Joyce Zhou, ...

Edwards Lifesciences (NYSE:EW) FY Conference January 12, 2026 02:15 PM ET Company ParticipantsScott Ullem - CFOBernard Zovighian - CEOConference Call ParticipantsRobbie Marcus - AnalystRobbie MarcusWelcome, everyone. I'm Robbie Marcus, the MedTech analyst at JPMorgan. Very happy to introduce our next speaker, Bernard Zovighian, at Edwards. Bernard is going to do a presentation followed by some Q&A.Bernard ZovighianThank you, Robbie, for hosting. Good morning, everyone. Great to see all of you. I'm very exci ...

Waystar (NasdaqGS:WAY) FY Conference January 12, 2026 02:15 PM ET Company ParticipantsAlexei Gogolev - Head of Vertical SaaS and HealthTech TeamMatt Hawkins - CEOAlexei GogolevHello, everyone. This is Alexei Gogolev, head of Vertical SaaS and HealthTech Team here at J.P. Morgan Equity Research. Today, I'm delighted to have CEO Matt Hawkins at Waystar present at our conference. Matt, welcome, and look forward to your presentation.Matt HawkinsThank you, and good morning to everybody. I look forward to sharing ...

Pacific Biosciences of California (NasdaqGS:PACB) FY Conference January 12, 2026 01:30 PM ET Company ParticipantsChristian Henry - CEOModeratorHello, everyone, and welcome to the 44th Annual JPMorgan Healthcare Conference. My name is Max Marks, and I'm an associate on the JPM Healthcare Investment Banking team. It is my pleasure to introduce Christian Henry, CEO of PacBio.Christian HenryThank you. Thank you, Max. Thank you to the JPMorgan team for the opportunity to present today. As Max said, my name is Ch ...

Medtronic FY Conference Summary Company Overview - **Company**: Medtronic (NYSE: MDT) - **Industry**: Medical Technology (MedTech) - **Focus Areas**: Cardiovascular, Neuroscience, Medical-Surgical, Diabetes Key Business Insights - Medtronic is positioned to accelerate revenue and earnings growth through innovation and strategic portfolio management [2][4] - The company has a diversified portfolio targeting high-growth, high-margin opportunities, with a total market opportunity of $100 billion [2] - Medtronic's diabetes business, generating nearly $3 billion in revenue, is planned to be separated via an IPO by the end of the calendar year [2] Generational Growth Drivers 1. **Pulsed Field Ablation (PFA)**: - Represents a $13 billion market opportunity, growing at 25% annually [5][6] - Expected to reach $2 billion in trailing revenue by the first half of fiscal 2027 [6] - Focus on increasing catheter utilization and expanding software offerings [6] 2. **Symplicity (Hypertension Treatment)**: - Addresses uncontrolled hypertension affecting 50% of adult Americans [8][9] - Over 18 million U.S. patients are eligible, with a 1% market penetration representing a multi-billion-dollar opportunity [9] - Plans to innovate with a transradial approach and combined denervation techniques [9][10] 3. **AltaViva (Neuromodulation Device)**: - Targets urge urinary incontinence (UUI) with a potential $1 billion revenue opportunity from a 1% penetration of the eligible patient pool [10][11] - Significant physician training and direct-to-consumer awareness initiatives are underway [11] 4. **Hugo (Robotic-Assisted Surgery)**: - Recently received FDA clearance for urology indications, with plans to expand into hernia and gynecology [12][14] - Differentiated by modularity, open console design, and integration with digital ecosystems [14][15] Operational Improvements - Implementation of the Medtronic Performance System has enhanced operational execution and quality outcomes [3] - Achieved a 5% gross cost improvement in COGS, with backorder levels at all-time lows [3] - Focus on margin expansion and increased R&D investment to fuel future growth [2][16] Strategic Initiatives - Commitment to tuck-in M&A to supplement organic growth, particularly in high-growth areas [17][41] - R&D spending is targeted to increase from 8.5% to 10% of revenue, prioritizing generational growth opportunities and high-growth franchises [26][29] - The diabetes business spin-off aims to simplify operations and redirect capital to higher-return areas [30] Market Position and Competitive Landscape - Medtronic is focused on maintaining leadership in established franchises while pursuing new market opportunities [39][40] - The company is positioned to capture significant market share in emerging areas like renal denervation and surgical robotics [40][54] Financial Outlook - Anticipated revenue growth driven by the successful launch of new products and strategic investments [16][39] - The company is optimistic about achieving durable revenue acceleration and margin improvement over the coming years [16][19] Conclusion - Medtronic is at a pivotal moment, leveraging its innovation-driven approach and strategic initiatives to enhance its market position and drive future growth [17][18]

Summary of ResMed's Conference Call Company Overview - **Company**: ResMed - **Market Cap**: Approximately $37 billion [2] - **Revenue**: $5.3 billion in the trailing 12 months with gross margins around 59-62% and net operating profit margins above 30% [3][30] - **Business Segments**: - Sleep health and breathing health solutions - Software business contributing 12% of revenue [3][4] - **Geographic Distribution**: 58% of revenue from the US, Canada, and Latin America; strong presence in Europe and Asia [3] Investment Opportunity - **Target Markets**: Large addressable markets including sleep apnea, insomnia, and chronic obstructive pulmonary disease [4][5] - **Megatrends**: - Integration of sleep apnea detection in wearables by Big Tech (e.g., Apple, Samsung) [5][44] - Increased patient flow into healthcare due to new GLP-1 drugs [6][22] - **Innovation and Operating Excellence**: Strong cash flow generation of $1.8 billion in the last 12 months, with a focus on R&D, share buybacks, and acquisitions [6][30] Product Innovations - **New Products**: - AirTouch N30i and AirTouch F30i masks with fabric technology for improved comfort [12][53] - AI-enabled medical devices to enhance patient adherence to therapy [13][15] - **Digital Health Initiatives**: Launch of a digital sleep health concierge named Dawn to assist patients in managing their sleep health [16] Market Dynamics - **Competitive Landscape**: - ResMed maintains a strong lead over competitors in the US and globally, with a focus on innovation and patient adherence [35][36] - A major competitor has returned to the market, but ResMed has continued to grow its market share [37] - **Regulatory Environment**: - CPAP therapy excluded from the latest round of competitive bidding, which is seen as a positive for the industry [38][39] Patient Engagement and Education - **Primary Care Physician Education**: - 60,000 CME courses on sleep apnea have been downloaded, with 77% of physicians indicating they will change their practice protocols [26] - **Patient Adherence**: - Patients on GLP-1 medications show higher adherence rates to CPAP therapy, with a 10.8% higher probability of starting CPAP treatment [23][50] Financial Performance - **Capital Distribution**: Over $3.7 billion distributed in the last three years, with a focus on R&D and shareholder returns [30][31] - **Share Repurchases**: Plans for at least $600 million in share repurchases in fiscal year 2026 [31] Future Outlook - **Growth Projections**: Anticipated high single-digit growth with continued leverage on the P&L [33] - **Manufacturing Expansion**: New facilities in the US to support increased manufacturing capacity, aligning with the "Made in America" initiative [29] Conclusion - ResMed is positioned as a compelling investment opportunity due to its strong market presence, innovative product offerings, and strategic focus on patient engagement and education [34]

BioCryst Pharmaceuticals (NasdaqGS:BCRX) FY Conference January 12, 2026 01:30 PM ET Company ParticipantsBabar Ghias - CFOBill Sheridan - Chief Development OfficerCharlie Gayer - CEOConference Call ParticipantsNone - AnalystJess Fye - AnalystJess FyeGreat. Welcome. Good morning, everyone. My name's Jess Fye. I'm a biotech analyst at JPMorgan. We're so glad to have you here at the 44th Annual JPMorgan Healthcare Conference. We're continuing the conference with BioCryst. And first, you're going to hear a prese ...

Summary of Ultragenyx Pharmaceutical FY Conference Call Company Overview - **Company**: Ultragenyx Pharmaceutical (NasdaqGS:RARE) - **Focus**: Development of treatments for rare diseases, with a strategy centered on potent biology and innovative drug development methods [1][2] Core Points and Arguments Product Development and Pipeline - **Commercial Products**: Since going public in 2014, Ultragenyx has four commercial products approved, generating revenue in over 30 countries [2] - **Setrusumab Program**: Recent trials for Setrusumab were disappointing, missing primary endpoints but showing improvements in bone mineral density and patient-reported outcomes [3][4][10] - **Trial Designs**: Two phase 3 studies (Orbit and COSMIC) were conducted, with Orbit being placebo-controlled and COSMIC being active-controlled for younger patients [5][6] - **Fracture Rates**: In the Orbit study, the fracture rates did not show significant differentiation between treatment and placebo groups, raising questions about the drug's efficacy [11][12] - **Bone Mineral Density**: Setrusumab demonstrated substantial improvements in bone mineral density, particularly in trabecular bone, but the expected reduction in fractures was not achieved [10][14] Future Developments - **Gene Therapy Programs**: - **Sanfilippo Syndrome**: A gene therapy program is expected to file for approval soon, with strong data supporting its efficacy [17] - **DTX401 for Glycogen Storage Disease**: A BLA filing was completed, showing significant demand and positive outcomes in reducing cornstarch needs for patients [18][19] - **GTX-102 for Angelman Syndrome**: Phase 3 data is anticipated in the second half of the year, with promising results in developmental improvements [20][21] Financial Outlook - **Revenue Growth**: Expected revenue of $62-$674 million, reflecting a 20% growth rate, with plans for expense and headcount reductions to maintain profitability goals by 2027 [24][25][26] - **Cash Position**: The company has $735 million in cash and anticipates receiving two PRVs before the sunset clause in September [26] Important but Overlooked Content - **Patient-Centric Focus**: Pain management and functional improvements are prioritized by patients, even if regulatory endpoints focus on fracture rates [30][31] - **Regulatory Navigation**: The company is working to understand the data better before approaching regulatory bodies, particularly regarding the discrepancies in fracture rates and patient activity levels [32][34] - **Long-Term Data**: There is an expectation for long-term follow-up data to provide further insights into the efficacy of treatments, particularly for Setrusumab [36] Conclusion Ultragenyx is navigating challenges in its product pipeline while maintaining a strong focus on patient outcomes and revenue growth. The company is poised for significant developments in gene therapy and aims to achieve profitability by 2027, despite setbacks in recent clinical trials.

Summary of Sotera Health Company FY Conference Call Company Overview - **Company Name**: Sotera Health Company (NasdaqGS:SHC) - **Mission**: Safeguarding global health through its three business units: Sterigenics, Nordion, and Nelson Labs [2][3] - **Global Presence**: Over 5,000 customers in 50 countries, 3,100 employees, and 62 facilities across 13 countries [3] - **Customer Base**: Engages with 40 of the top 50 medical device companies and 9 of the top 10 pharmaceutical companies [3] Business Segments Sterigenics - **Largest Business Unit**: Represents about two-thirds of the company's revenue [4] - **EBITDA Margins**: Approximately 50% [4] - **Sterilization Methods**: 39% ethylene oxide, 49% gamma, and 12% eBeam [5] - **Service Model**: Operates as a service business, where customers drop off products for sterilization [5] Nordion - **Product Business**: World's largest provider of Cobalt-60, critical for sterilization [6] - **EBITDA Margins**: Approximately 60% [7] - **Cobalt Sourcing**: Obtains Cobalt-60 from reactors in multiple countries including China, Canada, and Russia [6] Nelson Labs - **Testing Services**: Leader in microbiological and analytical chemistry testing with about 3,000 customers [7] - **Revenue Composition**: 48% routine testing, 37% validation, and 15% advisory services [8] Financial Performance - **Revenue Growth**: Surpassed $1.16 billion in revenue, with a minimum growth of over 5% [10] - **CAGR**: 7% growth in top line and adjusted EBITDA since going public in 2020 [11] - **Free Cash Flow**: Targeting $500 million to $600 million in cumulative free cash flow from 2025 to 2027 [20] - **Leverage Ratio**: Aiming to reduce net leverage from 3.3 times to a target of 2-3 times [12] Strategic Priorities 1. **Customer Service Excellence**: Focus on providing end-to-end solutions [13] 2. **Growth Market Segmentation**: Targeting high-growth segments within med tech and pharma [14] 3. **Operational Excellence**: Enhancing free cash flow through disciplined capital deployment [15] 4. **Long-term Value Creation**: Aiming for consistent top-line growth of 5%-7% annually [17] Market Outlook - **Growth Projections**: Sterigenics expected to grow mid-single to high-single digits, Nelson Labs mid-single digits, and Nordion low-single to mid-single digits [18] - **Pricing Strategy**: Anticipating a price increase of 3%-4% across the company [30] Regulatory Environment - **NESHAP Standards**: New regulations for ethylene oxide have been extended to April 2028, impacting smaller competitors [33] - **Litigation Updates**: Favorable rulings in Georgia regarding ethylene oxide litigation, with ongoing cases in California [52][54] Investment Rationale - **Market Position**: Leader in a growing $18 billion addressable market with strong margins and cash flow [24] - **Regulatory Expertise**: Established expertise in navigating highly regulated markets [24] - **Growth Potential**: Continued investment in capacity and operational improvements expected to drive future growth [25] Conclusion - **Company Confidence**: Strong execution and commitment to delivering growth and cash flow, positioning Sotera Health as a compelling investment opportunity for the future [55]