Henry Schein (HSIC) Q1 2025 Earnings Call May 05, 2025 08:00 AM ET Speaker0 Good morning, ladies and gentlemen. Welcome to Henry Schein's First Quarter twenty twenty five Earnings Conference Call. At this time, all participants are in listen only mode. Later, we'll conduct a question and answer session. Please press the star key followed by one on your touch tone phone if you'd like to ask a question at the end of the call. If anyone should require operator assistance during the call, please press the star ...

Recursion Pharmaceuticals (RXRX) Q1 2025 Earnings Call May 05, 2025 08:00 AM ET Speaker0 Hi, everybody. My name is Chris Gibson, cofounder and CEO of Recursion, and I'm delighted to welcome you to our learnings call this morning. We're gonna go ahead and get started. Perfect. So, of course, important to note that we're gonna be providing forward looking information today, so please understand all of these important caveats. So I wanna begin by just talking a little bit about Recursion's mission, which is to ...

BioNTech (BNTX) Q1 2025 Earnings Call May 05, 2025 08:00 AM ET Speaker0 Welcome to BioNTech's First Quarter twenty twenty five Earnings Call. I would like to hand the call over to Michael Horowitz, Director of Investor Relations. Please go ahead. Speaker1 Thank you. Good morning and good afternoon. Thank you for joining BioNTech's First Quarter twenty twenty five Earnings Call. As a reminder, the slides we will be using during this call and the corresponding press release we issued this morning can be found ...

Twist Bioscience (TWST) Q2 2025 Earnings Call May 05, 2025 08:00 AM ET Company Participants Angela Bitting - SVP - Corporate Affairs & Chief Corporate Responsibility OfficerEmily Leproust - CEO and Co-FounderPatrick Finn - President & COOAdam Laponis - Chief Financial OfficerSubbu Nambi - Managing DirectorDoug Schenkel - Managing DirectorPuneet Souda - Senior MDTom Peterson - Senior Research Associate Conference Call Participants Luke Sergott - AnalystMatthew Sykes - AnalystVijay Kumar - AnalystMatt Larew - ...

Twist Bioscience (TWST) Q2 2025 Earnings Call May 05, 2025 08:00 AM ET Speaker0 day. Thank you for standing by. Welcome to Twist Bioscience's Second Quarter Financial Results Conference Call. At this time, all participants are in a listen only mode. After the speakers' presentation, there will be a question and answer session. Please note that today's conference is being recorded. I would now like to turn the call over to Angela Bidding, SVP of Corporate Affairs. Please go ahead. Speaker1 Thank you, operato ...

Financial Data and Key Metrics Changes - Total product revenues for Q1 2025 were $121.5 million, representing a year-over-year growth of 62% compared to $75 million in Q1 2024 [16][17] - Net loss for Q1 2025 was $59.4 million or $1.22 per share, an improvement from a net loss of $68.4 million or $1.44 per share in Q1 2024 [20] - Cash and cash equivalents at the end of Q1 2025 were $300.9 million, down from $315.4 million at year-end [20] Business Line Data and Key Metrics Changes - Avelity net product sales were $96.2 million for Q1 2025, representing 80% year-over-year growth from $53.4 million in Q1 2024 [17] - Sunosi net product revenues were $25.2 million for Q1 2025, a 17% year-over-year increase from $21.6 million in Q1 2024 [17][18] - Avelity led the market in TRx growth in Q1 with approximately 167,000 prescriptions, reflecting 76% year-over-year growth [21] Market Data and Key Metrics Changes - Avelity coverage remained stable in Q1 with 78% of all lives covered across channels and 63% in the commercial segment [22] - Sunosi total prescriptions were over 46,000, representing a 12% growth versus Q1 2024 [23] - Payer coverage for Sunosi was stable with 83% of lives covered across channels [25] Company Strategy and Development Direction - The company aims to advance three novel NDA stage product candidates: AXS-fourteen for fibromyalgia, AXS-five for Alzheimer's disease agitation, and AXS-twelve for narcolepsy [6][10] - The company is focused on executing multiple Phase III clinical programs to broaden the potential of current products and candidates [6] - The company anticipates a strong launch for Cymbravo, with positive feedback from healthcare providers regarding its clinical profile [25] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to navigate trade policy developments, stating that any potential impact would be immaterial [13] - The company expects 2025 to be a catalyst-rich year with potentially five marketed products across six indications by 2026 [15] - Management remains optimistic about achieving cash flow positivity based on the current operating plan [20][96] Other Important Information - The company has submitted an NDA for AXS-fourteen and anticipates a decision in Q2 2025 [7] - AXS-five has been granted breakthrough therapy designation by the FDA, with an sNDA submission planned for Q3 2025 [9] - The company is closely monitoring the competitive landscape, particularly regarding new entrants in the narcolepsy treatment space [35] Q&A Session Summary Question: Recent interactions with the FDA regarding developmental agents - Management indicated that dialogue with the FDA remains status quo and no changes have been noted regarding review teams or agency responsiveness [30] Question: DTC advertising plans for Avelity - A national campaign is expected to launch later this year, with a focus on engaging patients [34] Question: Coverage expectations for Avelity - Management aims to increase the number of covered lives and reduce utilization management barriers [68] Question: Expected cadence of coverage for Cymbravo - Management is focused on securing access quickly, acknowledging the competitive market [48] Question: Sales potential for AXS-fourteen in fibromyalgia - Management is enthusiastic about the market opportunity, with approximately 17 million people diagnosed in the U.S. [63] Question: Profitability outlook for 2025 - Management remains confident in achieving cash flow positivity but has not provided specific guidance on timing for profitability [96]

Financial Data and Key Metrics Changes - First quarter net sales were $263.2 million, up approximately 18% year over year, primarily driven by volume growth [19][25] - Adjusted gross margin in the first quarter was 45.7%, compared to 45.3% in the prior year period [19][26] - Adjusted EBITDA in the first quarter was $35.5 million, up approximately $5 million or 16% year over year [19][28] - Capital expenditures for the first quarter were $26.5 million, with cash on hand of $243.7 million at the end of the quarter [28] Business Line Data and Key Metrics Changes - The company signed a new distribution agreement with Pet Food Experts, which is expected to improve growth moving forward [19] - The total e-commerce business was up 43% in the quarter, indicating strong performance in online sales [12] - The company has a 96% market share within the gently cooked fresh frozen branded dog food segment [21] Market Data and Key Metrics Changes - Freshpet competes in the $54 billion U.S. pet food category, holding a 3.5% market share within the $37 billion U.S. dog food and treats segment [20] - Household penetration as of March 30 was 14.1 million households, up 13% year over year [22] - The average buy rate was $110, up 6% year over year [22] Company Strategy and Development Direction - The company plans to adapt its strategies to target higher-income consumers through increased advertising investment and tailored media strategies [9] - Freshpet will launch a new entry price point bag product under the Freshpet Complete Nutrition label to attract cost-conscious consumers [10] - The company aims to balance capacity and organizational capability investments with anticipated demand to meet long-term margin and cash generation targets [11] Management's Comments on Operating Environment and Future Outlook - Management noted a significant shift in the macro environment impacting growth, but Freshpet continues to outperform the category across all demographics [5] - The company expects net sales for 2025 to be between $1.12 billion and $1.15 billion, representing approximately 15% to 18% growth year over year [13][29] - Management remains optimistic about long-term growth potential despite current economic uncertainties, believing there will be pent-up demand for pets when conditions improve [15][34] Other Important Information - The company is monitoring tariffs closely, with only 5% of U.S. COGS coming from imported raw materials, minimizing the impact on the P&L [32] - Capital expenditures are projected to be approximately $225 million for the year, down from previous estimates [33] Q&A Session Summary Question: Updated guidance range in light of economic conditions - Management considered various scenarios and believes the current consumer environment will continue for the balance of the year, but is prepared to take actions if conditions worsen [36][39] Question: Incremental changes in value products and marketing strategies - The company is accelerating plans to improve affordability and mainstream the brand, focusing on media targeting and creative adjustments [45][46] Question: Market progression and growth challenges - Freshpet is outperforming the category across income groups, but consumer uncertainty is causing hesitance in trading up to premium pet food [56][58] Question: Inventory health and destocking risks - Inventory across most channels is in good shape, with no significant destocking issues expected [84][86] Question: Contingency plans if growth slows - The company has flexibility to adjust capital expenditures and staffing of production lines based on growth performance [94][96]

Financial Data and Key Metrics Changes - The company reported record attendance at its annual meeting, with 19,700 participants, up from 16,200 the previous year [2] - The company achieved record sales figures, with Candid at $317,000 compared to $283,000 the previous year [3] Business Line Data and Key Metrics Changes - Brooks reported sales of $310,000, marking an all-time record for the company [4] - Jazz Wear's sales doubled to around $250,000 compared to the previous year [4] Market Data and Key Metrics Changes - The company noted a significant increase in attendance and sales across all business lines, indicating strong market demand [5] Company Strategy and Development Direction - The management emphasized the importance of maintaining a diverse and capable board, with a focus on long-term relationships and investments, particularly in Japan [38][46] - The company is positioning itself for future opportunities, with a significant cash reserve of over $300 billion, representing about 27% of total assets, which is historically high [51] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the U.S. economy, despite current challenges, and highlighted the importance of adapting to changes while maintaining a long-term perspective [95][99] - The company is prepared for future investment opportunities, emphasizing that attractive deals will arise over time [60][61] Other Important Information - The company raised significant funds for charity through the sale of a commemorative book, showcasing its commitment to social responsibility [20][23] Q&A Session All Questions and Answers Question: Has your view on trade barriers changed? - Management discussed the historical context of trade barriers and emphasized the importance of balanced trade for global prosperity [26][30] Question: Do you think the Bank of Japan's rate hike will deter further investments in Japan? - Management expressed confidence in their Japanese investments and indicated a long-term commitment to holding these positions [36][38] Question: Is the high cash reserve a derisking strategy or for future capital allocation? - Management clarified that the cash reserve is not solely for Greg Abel's future flexibility but is a strategic position to capitalize on attractive investment opportunities as they arise [51][52] Question: With high interest rates, do you still believe in being greedy when others are fearful? - Management reiterated the advantages of investing in stocks over real estate due to the ease of transactions and opportunities in the stock market [64][66] Question: How will AI affect the insurance industry? - Management acknowledged AI as a game changer but emphasized a cautious approach to its integration into their operations [75][78] Question: How did the acquisition of Portillo's Hotdogs fit into the portfolio? - Management was not directly involved in the acquisition and noted that it was owned by a private equity firm, not Berkshire [80][92]

Financial Data and Key Metrics Changes - The company reported a 15% increase in net income and a 14% increase in earnings per share for FY 2024 [20] - Revenue remained relatively flat, with expenses increasing by about 2%, leading to a 3% decline in adjusted pre-provision net revenue [20] - Return on assets improved from 77 basis points in the prior year to 88 basis points in FY 2024 [20] - The efficiency ratio increased due to flat revenue and higher expenses, while charge-offs and credit quality remained strong at 10 basis points, significantly better than the industry average [21] Business Line Data and Key Metrics Changes - The bank's deposit franchise showed strong performance, with average non-interest bearing deposits as a percentage of total deposits higher than the top quartile in the industry [21] - Credit quality remained robust, with net loan losses staying very low, better than the top quartile [22] - The commercial real estate portfolio grew at a disciplined rate, with loss rates close to zero over the past five years [24] Market Data and Key Metrics Changes - The bank's capital position is about the median of its peer group, expected to strengthen as depreciation in the securities portfolio accretes back into capital over time [26] - The bank has consistently ranked among the best in customer relationships, receiving numerous awards since 2009 [27] Company Strategy and Development Direction - The company focuses on serving local communities and maintaining strong credit quality, with a particular emphasis on middle-market businesses [19] - The management is closely monitoring the economic environment, especially regarding tariffs and potential recession impacts, while aiming to support customers through challenging times [28] Management Comments on Operating Environment and Future Outlook - Management expressed optimism about the year ahead despite concerns regarding the economy and potential impacts from tariffs [28] - The company aims to maintain its strong credit culture to weather any economic challenges that may arise [23] Other Important Information - The bank's performance in FY 2024 reflected a recovery from the previous year's challenges, including the impact of bank failures on funding costs and net interest margins [20] - The bank's management structure is locally oriented, enhancing its ability to serve community needs effectively [19] Q&A Session Summary Question: What is the outlook for the commercial real estate portfolio? - Management noted that while there are concerns in the commercial real estate sector, particularly in office and multifamily segments, they do not anticipate material losses from their portfolio, which has been managed conservatively [24] Question: How does the bank plan to address potential economic downturns? - The bank intends to stay close to its customers and provide support during challenging times, leveraging its strong credit culture to navigate uncertainties [28] Question: What are the results of the recent shareholder votes? - All director nominees received over 97% approval, the appointment of Ernst and Young as auditors was approved by approximately 98%, and the executive compensation resolution received about 95% approval [30][31]

Financial Data and Key Metrics Changes - Core FFO for Q1 was reported at $1.21 per diluted share, reflecting a 2.1% year-over-year increase in same store NOI [13] - Revenues from same store communities increased by 3.5% compared to the same quarter of 2024, with occupancy rising by 120 basis points to 95.8% [13][14] - Same store expenses increased by 5.8% year-over-year, primarily due to property taxes [14] Business Line Data and Key Metrics Changes - The average physical occupancy for the same store portfolio improved to 96%, with renewal retention around 57% [5] - Blended leasing spreads increased by 70 basis points in Q1, with new lease spreads improving from negative 1.1% to positive 2.4% in April [5][6] - North Dakota led the portfolio with blended leasing spreads of 5.3% year-to-date, while Minneapolis showed positive leasing spreads [7][8] Market Data and Key Metrics Changes - Apartment demand remains resilient, with only a 2.2% expected expansion of apartment stock in the markets, down from 3.8% the previous year [9] - Institutional quality assets in Colorado and Minneapolis are pricing at mid to high 4% and low 5% cap rates, respectively [10] - The company’s footprint in the Midwest and Mountain West regions continues to benefit from a lack of new supply [6][10] Company Strategy and Development Direction - The company is maintaining discipline in all areas within its control and is ready to take advantage of opportunities to advance its platform [8] - Focus remains on enhancing the differentiated Mountain West and Midwest geography, with a robust balance sheet and capital positioning [11] - The company is evaluating new investment opportunities while being mindful of market exposures and leverage [11] Management's Comments on Operating Environment and Future Outlook - Management reaffirmed guidance for the full year, expecting to achieve a midpoint of $4.98 per share for core FFO and 2.25% year-over-year same store NOI growth [15][16] - The macroeconomic environment is expected to continue impacting results, but strong demand trends are anticipated to improve new lease rates as the year progresses [8][10] - Management expressed optimism about the demand in Denver, expecting an inflection point in rents towards the end of the year [39] Other Important Information - The company reported a total liquidity of over $223 million, including cash on hand and a line of credit [16] - Retention rates are expected to improve, with April showing a jump to about 58% [32][63] Q&A Session Summary Question: Midwest apartment market performance - Management acknowledged strong performance in the Midwest, particularly in North Dakota and Omaha, and confirmed that they expected strong growth [20] Question: Occupancy projections for 2025 - Management projected occupancy around 95% for the year, with current occupancy at 96% [23] Question: Operating expenses and lumpiness - Management indicated that lumpiness in operating expenses is expected primarily in the first and fourth quarters, with increased assessments in certain jurisdictions [30] Question: Denver market outlook - Management noted a 200 basis point improvement in new lease spreads in Denver from March to April, with expectations for an inflection point in rents by the end of the year [39] Question: Impact of agriculture on local economies - Management stated that while agriculture is significant, the primary economic drivers in their markets are healthcare and education [56] Question: Retention rates compared to peers - Management explained that lower retention rates in Denver were impacting overall figures, but strong retention was observed in other markets [62]