Kymera's Strategy and Pipeline - Kymera is focused on developing oral degrader medicines with biologics-like activity to transform immunology treatments[7, 16] - The company's pipeline includes KT-621 (STAT6 degrader), KT-579 (IRF5 degrader), and KT-485 (IRAK4 degrader), targeting various immunological diseases[27] - Kymera expects to report Phase 2b AD study data by mid-2027 and Phase 2b asthma study data in late-2027 for KT-621[27, 92] - A Phase 1 healthy volunteer trial for KT-579 is expected to initiate in Q1 2026, with data reported in 2H 2026[27, 92] - Sanofi plans to advance KT-485 into a Phase 1 clinical trial in 2026[14, 91] KT-621 Clinical Data and Market Opportunity - KT-621 has shown deep STAT6 degradation (>95%) in healthy volunteers and AD patients[44] - In the BroADen Phase 1b AD trial, KT-621 achieved significant reductions in EASI score (-63%), Total SCORAD (-48%), Peak Pruritus NRS (-40%), and SCORAD-Itch (-44%)[53, 54, 57] - KT-621 also demonstrated improvements in patient-reported outcomes, with 61% DLQI responders and 75% POEM responders[60] - KT-621 achieved a 56% median FeNO reduction in AD patients with comorbid asthma[71] - The potential patient impact for STAT6 inhibition in Type 2 inflammation is estimated to be >140 million, representing a >$20 billion market[35] Financial Position - Kymera is capitalized with $1.6 billion in cash, providing a runway into 2029[14]

Agilent Technologies Padraig McDonnell, President & CEO J.P. Morgan Healthcare Conference January 13, 2026 2026 J.P. Morgan Healthcare Conference Safe harbor This presentation contains forward-looking statements (including, without limitation, statements on Agilent's (the "company" or "our") strategy, priorities, growth and growth opportunities, productivity, reinvestment, customer focus, evolving product mix, work environment and innovation plans; the effects of the Ignite Operating System; the size and gr ...

Financial Performance and Guidance - Cardinal Health raises its fiscal year 2026 non-GAAP diluted EPS guidance to at least $10.00, up from the previous range of $9.65 to $9.85[5] - The company anticipates approximately $3.4 billion in operating earnings for fiscal year 2026[19] - Cardinal Health expects approximately $3.25 billion in adjusted free cash flow for fiscal year 2026[20] Specialty Growth - Specialty revenue is projected to exceed $50 billion in fiscal year 2026, representing a 16% compound annual growth rate (CAGR) over three years[5, 35] - BioPharma Solutions is expected to grow over 30% in fiscal year 2026[37, 45] - Cardinal Health's MSOs contribute approximately $4.5 billion in higher-margin revenue[42] Strategic Initiatives - Cardinal Health is introducing ContinuCare Pathway to simplify diabetes supply management for pharmacies and patients, partnering with Publix Super Markets Inc[7] - The company is prioritizing growth in therapeutic areas such as autoimmune, urology, and oncology[37] - Cardinal Health aims to achieve $1 billion in higher-margin revenue from BioPharma Solutions by fiscal year 2028[43] Overall Strategy - Cardinal Health is focused on simplification, expanding in Specialty, accelerating other growth businesses, and executing GMPD Improvement Plan initiatives[34] - The company highlights a consistent track record, unique breadth of capabilities, and a resilient business model[57]

44th Annual J.P. Morgan Healthcare Conference January 13, 2026 1 Non-GAAP Financial Measures This presentation includes the presentation and discussion of certain financial information that differs from what is reported under accounting principles generally accepted in the United States ("U.S. GAAP"). These non-GAAP financial measures, including, but not limited to, adjusted EBITDA, free cash flow, free cash flow excluding transaction-related costs, and adjusted EPS, are presented in order to supplement inv ...

44th Annual J.P. Morgan Healthcare Conference 2026 Breakthrough Therapies Driving Accelerating Growth Brett Monia, Ph.D. Chief Executive Officer January 2026 | Nasdaq: IONS Forward-Looking Statements This presentation includes forward-looking statements regarding our business, financial guidance and the therapeutic and commercial potential of our commercial medicines, additional medicines in development and technologies and our expectations regarding development and regulatory milestones. Any statement desc ...

Forward Looking Statement This presentation contains contains forward-looking statements as that term is defined in Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Statements in this presentation that are not purely historical are forward-looking statements. Such forward-looking statements include, among other things, statements regarding the potential of, and expectations regarding, Edgewise's product candidates and programs, including sevasemten, EDG-7500, ...

J.P. Morgan Healthcare Conference January 13, 2026 Marc N. Casper Chairman, President and Chief Executive Officer The world leader in serving science Various remarks that we may make in the following presentation about the company's future expectations, plans and prospects constitute forward-looking statements for purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995, including statements about future revenue and financial results. Forward-looking statements are b ...

Cautionary Note Regarding Forward-Looking Statements This presentation contains forward -looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, which are based on management 's current beliefs and expectations and are subject to substantial risks and uncertainties, both known and unknown, that could cause our future results, performance or achievements to differ significant ly from that expressed or implied by such forward -looking statements. Important factors that c ...

J.P. Morgan Annual Meeting January 13, 2026 Forward-Looking Statements and Risk Factors This presentation and the accompanying oral commentary contain forward-looking statements that involve risks, uncertainties and assumptions. If the risks or uncertainties ever materialize or the assumptions prove incorrect, our results may differ materially from those expressed or implied by such forward looking statements. All statements other than statements of historical fact could be deemed forward-looking, including ...

J.P. Morgan Healthcare Conference David J. Endicott Chief Executive Officer January 13th, 2026 Safe harbor Forward-looking statements This document contains, and our officers and representatives may from time to time make, certain "forward-looking statements" within the meaning of the safe harbor provisions of the US Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as "anticipate," "intend," "commitment," "look forward," "maintain," "plan," "goal," ...