Core Viewpoint - AB Science provides an update on its AB8939 program, a novel microtubule destabilizer and ALDH inhibitor, currently in Phase 1 trials for treating acute myeloid leukemia (AML) [2]. Group 1: Product Profile and Mechanism - AB8939 is a next-generation synthetic microtubule destabilizer and stem cell-targeted ALDH1/2 inhibitor, designed for refractory/relapsing AML treatment [3]. - The drug destabilizes microtubules and is not affected by multidrug resistance mechanisms, as it does not bind to PgP and is not degraded by myeloperoxidase [4]. - AB8939 inhibits ALDH1/2, promoting the repopulation of normal progenitors in the bone marrow [5]. Group 2: Clinical Efficacy and Market Potential - AB8939 demonstrates activity across refractory AML cell lines and shows an additive effect when combined with first-line treatments like cytarabine, azacitidine, and venetoclax [6]. - The drug has potential efficacy in AML with MECOM gene rearrangement, a patient subset known for extreme resistance to chemotherapy and poor survival prognosis [7]. - The addressable market for AB8939 in relapsed/refractory AML is estimated to exceed EUR 2 billion annually [7]. Group 3: Market Size Data - In the USA and Canada, there are approximately 23,700 incidence cases of AML, with a 50% relapse or refractory rate, leading to a market size of EUR 1 billion [8]. - Europe has around 27,600 incidence cases, with a market size of EUR 770 million [8]. - The Asia-Pacific region reports 27,800 incidence cases, with a market size of EUR 250 million [8]. Group 4: Clinical Development and Intellectual Property - The Phase 1 trial aims to determine the maximum tolerated dose (MTD) of AB8939, with 28 patients enrolled in the first step and 10 in the second step [11]. - Future steps include evaluating the MTD after 14 consecutive days of treatment in combination with venetoclax or azacitidine [12]. - AB8939's intellectual property rights in AML are secured until 2036, with potential extension until 2044 for specific chromosome abnormalities [18].

Core Insights - AllianceBernstein L.P. and AllianceBernstein Holding L.P. reported a preliminary increase in assets under management (AUM) to $813 billion in November 2024, up from $793 billion at the end of October, representing a 2.5% month-over-month growth driven by market appreciation, despite net outflows [1][2]. AUM Breakdown - Total AUM as of November 30, 2024, includes: - Total Equity: $343 billion, up from $333 billion in October, with actively managed equity at $272 billion and passive equity at $71 billion [2]. - Total Fixed Income: $303 billion, an increase from $296 billion in October, with taxable fixed income at $215 billion and tax-exempt fixed income at $77 billion [2]. - Alternatives/Multi-Asset Solutions: $167 billion, up from $164 billion in October [2]. - By channel, net inflows in Retail and Private Wealth were outweighed by Institutional net outflows [1].

Group 1 - AllianceBernstein L.P. and AllianceBernstein Holding L.P. announced that Seth Bernstein, President and CEO, will participate in the Goldman Sachs 2024 US Financial Services Conference on December 10, 2024 [1] - A live audio webcast of the conference will be available on AB's website, with a replay accessible shortly after the event [2] - AllianceBernstein is a leading global investment management firm providing high-quality research and diversified investment services to various clients [3] Group 2 - As of September 30, 2024, AllianceBernstein Holding owned approximately 39.3% of AllianceBernstein, while Equitable Holdings, Inc. owned an approximate 61.6% economic interest in the firm [4]

Group 1 - Investment operations may involve the use of specific portfolio management techniques, including credit [1]

Innovative portfolios combining individual stocks and bonds in one holistic tax-managed SMANASHVILLE, Tenn., Nov. 19, 2024 /PRNewswire/ -- AllianceBernstein L.P. ("AB") (NYSE: AB), a leading global investment management firm, has launched the AB Tax Advantaged Balanced Direct Index portfolio, combining equities and municipal bonds into a core separately managed account.AB will provide a multi-asset solution within a single account — custom tailored to client tax situation and risk preferences — to deliver b ...

AllianceBernstein Holding L.P. (AB) has announced assets under management (AUM) for October 2024. The company’s preliminary month-end AUM of $806 billion reflects a 2% decrease from the end of September 2024.The fall was primarily due to market depreciation. In October, firmwide net flows were stable.At the end of October, AllianceBernstein’s Equity AUM declined 2.1% sequentially to $333 billion. Alternatives/Multi-Asset Solutions AUM (including certain multi-asset services and solutions) was down 2.4% to $ ...

NASHVILLE, Tenn., Nov. 13, 2024 /PRNewswire/ -- AllianceBernstein L.P. ("AB") (NYSE: AB), a leading global investment management firm, today announced plans to expand its insurance business through a non-exclusive partnership with Reinsurance Group of America, Incorporated ("RGA") (NYSE: RGA).AB has been named as one of the lead investors in Ruby Reinsurance Company ("Ruby Re"), a reinsurance sidecar vehicle sponsored by RGA and focused on the U.S. asset-intensive market. As part of this transaction, AB int ...

NASHVILLE, Tenn., Nov. 12, 2024 /PRNewswire/ -- AllianceBernstein L.P. ("AB") and AllianceBernstein Holding L.P. ("AB Holding") (NYSE: AB) today announced that preliminary assets under management decreased to $793 billion during October 2024 from $806 billion at the end of September. The 2% decrease in month-end AUM was entirely driven by market depreciation, as firmwide net flows were flat in October. By channel, net inflows in Private Wealth and Retail were offset by Institutional net outflows. Alliance ...

In the wake of a very bullish response to the re-election of Donald Trump and a stellar rally before Election Day, most investors will be feeling rather upbeat heading into the holiday season.Freelance Financial Writer | Investments | Markets | Personal Finance | RetirementI create written content used in various formats including articles, blogs, emails, and social media for financial advisors and investment firms in a cost-efficient way. My passion is putting a narrative to financial data. Working with te ...

Momentum investing is essentially the opposite of the tried-and-tested Wall Street adage -- "buy low and sell high." Investors following this investing style typically avoid betting on cheap stocks and waiting long for them to recover. They believe instead that one could make far more money in lesser time by "buying high and selling higher."Everyone likes betting on fast-moving trending stocks, but it isn't easy to determine the right entry point. These stocks often lose momentum when their future growth po ...