Data highlighted in oral presentation at the European Association for the Study of the Liver (EASL) Congress WARMISTER, Pa., June 06, 2024 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (NASDAQ:ABUS) ("Arbutus" or the "Company"), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop a functional cure for people with chronic hepatitis B virus (cHBV) infection, announced new preliminary end-of-treatment (EOT) data from the Phase 2a clinical trial (IM-PROVE II, A ...

Data highlighted in oral presentation at the European Association for the Study of the Liver (EASL) Congress WARMISTER, Pa., June 06, 2024 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS) (“Arbutus” or the “Company”), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop a functional cure for people with chronic hepatitis B virus (cHBV) infection, announced new preliminary end-of-treatment (EOT) data from the Phase 2a clinical trial (IM-PROVE II, ...

At the end of treatment, 33.3% of patients receiving imdusiran for 48 weeks, interferon (IFN) for 24 weeks and ongoing nucleoside analogue (NA) therapy achieved undetectable levels of HBsAg that were maintained in 100% of these patients 24 weeks after completing imdusiran and IFN treatment Of the patients who have stopped all therapy, six still have undetectable levels of HBsAg and HBV DNA, with two of these patients reaching 12 weeks off all therapy All six patients have seroconverted and have high titers ...

Core Insights - The Phase 2a clinical trial IM-PROVE I demonstrated that imdusiran combined with pegylated interferon (IFN) and ongoing nucleoside analogue (NA) therapy resulted in significant reductions in HBsAg levels, with 33.3% of patients achieving undetectable HBsAg at the end of treatment, which was maintained in 100% of these patients 24 weeks post-treatment [1][2][3] Group 1: Clinical Trial Results - 33.3% of patients receiving imdusiran for 48 weeks and IFN for 24 weeks achieved undetectable HBsAg levels at the end of treatment, sustained in 100% of these patients 24 weeks after treatment [1][2] - Among patients who discontinued all therapy, six maintained undetectable levels of HBsAg and HBV DNA, with two achieving this status for 12 weeks off therapy [1][2] - All six patients with sustained HBsAg loss have seroconverted, showing high levels of anti-HBsAg antibodies, indicating potential immune control [2][3] Group 2: Safety and Tolerability - The combination of imdusiran and IFN was generally safe and well-tolerated, with no serious adverse events related to either treatment [4] - The most common treatment-emergent adverse events included transient ALT elevations and injection site bruising, consistent with known safety profiles [4][5] Group 3: Company Overview and Future Directions - Arbutus Biopharma is focused on developing a functional cure for chronic hepatitis B virus (cHBV) infection, with imdusiran being a key component of their therapeutic strategy [9][10] - The company is conducting multiple Phase 2a trials to evaluate imdusiran in combination with other immunomodulators, aiming to enhance treatment efficacy [5][10] - The global burden of chronic HBV infection is significant, with over 250 million people affected worldwide, highlighting the urgent need for effective treatments [8]

VANCOUVER, British Columbia, June 03, 2024 (GLOBE NEWSWIRE) -- Mr. Peter Bull and Arbutus Distributors Ltd. (“Arbutus”), a private investment and holding company controlled by Mr. Bull, announced today that Mr. Bull and Arbutus disposed of an aggregate of 2,050,000 common shares (the “Subject Shares”) of ADENTRA Inc. (“ADENTRA”) at a sale price of $38.06 per Subject Share for aggregate gross proceeds of $78,023,000 on the Toronto Stock Exchange through a block sale on May 31, 2024 (the “Transaction”). ADENT ...

WARMINSTER, Pa., May 22, 2024 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (NASDAQ:ABUS) ("Arbutus" or the "Company"), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop a functional cure for people with chronic hepatitis B virus (cHBV) infection, today announced that two abstracts have been accepted for poster and oral presentations at the European Association for the Study of the Liver (EASL) Congress 2024 taking place June 5 - 8, 2024 in Milan, Italy. T ...

WARMINSTER, Pa., May 22, 2024 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS) (“Arbutus” or the “Company”), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop a functional cure for people with chronic hepatitis B virus (cHBV) infection, today announced that two abstracts have been accepted for poster and oral presentations at the European Association for the Study of the Liver (EASL) Congress 2024 taking place June 5 - 8, 2024 in Milan, Italy. ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from to Commission File Number: 001-34949 ARBUTUS BIOPHARMA CORPORATION (Exact Name of Registrant as Specified in Its Charter) British Columbia, Canada 98-0597776 (State or O ...

Arbutus Biopharma Corporation (NASDAQ:ABUS) Q1 2024 Earnings Conference Call May 2, 2024 8:45 AM ET Company Participants Lisa Caperelli - Vice President, Investor Relations Mike McElhaugh - Interim President and Chief Executive Officer and Director Mike Sofia - Chief Medical Officer Karen Sims - Chief Medical Officer David Hastings - Chief Financial Officer Conference Call Participants Dennis Ding - Jefferies Thomas Yip - H.C. Wainwright Roy Buchanan - Citizens JMP Keay Nakae - Chardan Operator Good day, an ...

Arbutus Biopharma (ABUS) came out with a quarterly loss of $0.10 per share in line with the Zacks Consensus Estimate. This compares to loss of $0.10 per share a year ago. These figures are adjusted for non-recurring items.A quarter ago, it was expected that this biopharmaceutical company would post a loss of $0.12 per share when it actually produced a loss of $0.12, delivering no surprise.Over the last four quarters, the company has surpassed consensus EPS estimates just once.Arbutus, which belongs to the Z ...