Intuitively, the case for biotechnology-related investments comes across rather obviously: the concept of healthcare should be a permanent one. And because of this permanence, the expected market value of the ecosystem should be massive. Grand View Research estimates that it would be worth $3.88 trillion by 2030. Still, the opportunistic investor may want to consider cheap biotech stocks.It comes down to adding more pieces on the table. You can always elect the high-flying names that command rich multiple p ...

UKRAINE - 2021/05/27: In this photo illustration, the Alnylam Pharmaceuticals logo seen on a ... [+] smartphone and a pc screen. (Photo Illustration by Pavlo Gonchar/SOPA Images/LightRocket via Getty Images)SOPA Images/LightRocket via Getty ImagesAlnylam Pharmaceuticals stock (NASDAQ: ALNY), a pharmaceutical company focused on RNA interference therapeutics for genetically defined diseases, has seen a significant rise of 60% in a week. This can be attributed to positive data from a late-stage clinical trial ...

Core Viewpoint - Alnylam Pharmaceuticals achieved a new 52-week high following positive results from the phase III HELIOS-B study of Amvuttra (vutrisiran), leading to a 34.5% increase in stock price [1]. Group 1: Study Results - The HELIOS-B study met its primary endpoint, showing a statistically significant reduction in all-cause mortality and recurrent cardiovascular events in both the overall and monotherapy populations [2]. - Statistically significant improvements were observed across all secondary endpoints, including key measures of disease progression at Month 30 [2]. - Vutrisiran reduced all-cause mortality in both populations up to Month 42, based on a pre-specified intent-to-treat analysis [2]. Group 2: Patient Population and Safety - The study enrolled 655 adult patients with ATTR amyloidosis and cardiomyopathy, who received either vutrisiran or placebo [3]. - Vutrisiran demonstrated a favorable safety and tolerability profile, with adverse event rates similar to the placebo group [4]. Group 3: Market Potential and Financial Performance - Alnylam plans to submit global regulatory applications starting in late 2024, aiming for vutrisiran to become the new standard of care for ATTR amyloidosis with cardiomyopathy [4]. - Amvuttra generated $195 million in sales in Q1, reflecting a 92% increase, driven by new patient uptake and switches from Onpattro [5].

Key TakeawaysAlnylam Pharmaceuticals announced a Phase-3 study of its treatment for a rare heart condition showed a significant reduction in deaths and recurrent cardiovascular events.The biopharmaceutical company said it would be seeking regulatory approval later this year, including asking the Food and Drug Administration for a priority review.The news sent shares of Alnylam soaring over 31% in early trading Monday. Shares of Alnylam Pharmaceuticals (ALNY) skyrocketed over 31% in early trading Monday afte ...

Follow Invezz on Telegram , Twitter , and Google News for instant updates >Alnylam Pharmaceuticals Inc (NASDAQ: ALNY) opened more than 30% up on Monday after reporting promising results from a late-stage trial of its heart drug. Are you looking for signals & alerts from pro-traders? Sign-up to Invezz Signals™ for FREE. Takes 2 mins.Shares of the biopharmaceutical company are now trading at a year-to-date high of $220.  Why is it significant for Alnylam Pharmaceuticals stock?Copy link to sectionVutrisiran de ...

Company Overview - Alnylam Pharmaceuticals (ALNY) shares increased by 5.3% to $165.70, with a notable trading volume, reflecting a 5.4% gain over the past four weeks [1][2] - The rise in stock price is attributed to investor optimism regarding Amvuttra's (vutrisiran) revenue potential, which recorded sales of $195 million in Q1 2024, a 92% increase [2] Financial Performance - Alnylam is expected to report a quarterly loss of $0.78 per share, representing a year-over-year change of +64.7%, with revenues projected at $450.23 million, up 41.3% from the previous year [3] - The consensus EPS estimate has been revised slightly higher in the last 30 days, indicating a positive trend that may lead to stock price appreciation [3] Industry Context - Alnylam operates within the Zacks Medical - Biomedical and Genetics industry, which includes other companies like Acadia Pharmaceuticals (ACAD), whose stock rose by 3.7% to $15.30 [4] - Acadia's consensus EPS estimate has decreased by 2.8% over the past month, but shows a significant year-over-year change of +1500% [4]

Editor's note: Seeking Alpha is proud to welcome SA's Undercovered Dozen Series as a new contributing analyst. You can become one too! Share your best investment idea by submitting your article for review to our editors. Get published, earn money, and unlock exclusive SA Premium access. Click here to find out more » cassp/E+ via Getty Images Introduction There's lots to like in our first weekly edition of The "Undercovered" Dozen. We'll be presenting ideas that were published during June 1st - 6th. So f ...

Wall Street regards the healthcare sector as a constant source of innovation, while biotechnology stands at the pinnacle of groundbreaking medical advancements. The long-term potential of robust biotech stocks to buy remains undeniable for investors. As the summer season kicks in, several biotech companies exhibit characteristics that could ignite this potential summertime surge. Promising clinical trial results, significant product launches, or strategic partnerships could drive this momentum.We should not ...

Financial Data and Key Metrics Changes - In Q1 2024, Alnylam Pharmaceuticals reported total product revenues of $365 million, reflecting a 32% year-over-year growth compared to Q1 2023 [7][26] - The gross margin on product sales was 85%, consistent with Q1 2023, but expected to decrease for the remainder of 2024 due to higher royalties on AMVUTTRA [27][28] - Non-GAAP R&D expenses increased by 13% year-over-year, driven by investments in zilebesiran and the HELIOS-B trial [27] - Non-GAAP SG&A expenses rose by 15% year-over-year, indicating operating leverage as product sales grew by 32% [27] Business Line Data and Key Metrics Changes - The TTR franchise achieved $264 million in global net product revenues, representing a 29% growth year-over-year [11][12] - The rare franchise delivered $101 million in combined global net product revenue, marking a 40% increase compared to Q1 2023 [16][17] - AMVUTTRA's U.S. sales increased by 35% year-over-year, driven by strong patient uptake [11][12] Market Data and Key Metrics Changes - The U.S. TTR sales saw a 39% increase in total demand compared to Q1 2023, despite a decrease in patients switching from ONPATTRO to AMVUTTRA [12][14] - International TTR franchise growth increased by 23% year-over-year, primarily due to AMVUTTRA demand in newly launched markets [13][14] Company Strategy and Development Direction - Alnylam aims to position itself as a leader in treating cardiovascular disease through its zilebesiran hypertension program, which has shown positive results in clinical trials [8][21] - The company is focused on advancing its pipeline with plans to file proprietary INDs for nine programs by the end of 2025, aiming to double its clinical pipeline [24][29] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in a strong start to 2024, with expectations for continued revenue growth and successful outcomes from ongoing clinical trials [7][9] - The company remains optimistic about the HELIOS-B Phase 3 study results, which are expected to support a supplemental NDA filing by the end of 2024 if positive [9][20] Other Important Information - Alnylam ended Q1 2024 with cash, cash equivalents, and marketable securities of $2.4 billion, indicating a stable financial position [28] - The company reiterated its 2024 guidance for combined net product revenues between $1.4 billion and $1.5 billion, reflecting a growth rate of 13% to 21% [29] Q&A Session Summary Question: What is the relevant improvement over the control arm for HELIOS-B? - Management emphasized that delivering outcomes in the HELIOS-B study is crucial and that they are focused on demonstrating clinical significance in terms of mortality and hospitalization [34][36] Question: What would be the organizational changes if HELIOS-B succeeds or fails? - If HELIOS-B succeeds, no changes to spending guidance are anticipated. However, if it fails, prioritization across the business would be necessary [40][41] Question: How important is the ratio between hospitalization events and deaths in HELIOS-B? - Management indicated that both hospitalization and mortality events are clinically meaningful and should trend in the same direction [70][72] Question: What proportion of patients are mixed phenotype in ATTR? - It was noted that a significant proportion of patients with wild type ATTR may have concomitant polyneuropathy, highlighting the complexity of the disease [75][76] Question: Will subgroup information be shared in the top line release for HELIOS-B? - Management confirmed that they plan to provide information on primary and secondary endpoints, including subgroup analyses, during the top line results presentation [61][80]

Financial Performance - Alnylam's combined net product revenue reached $365 million, a 32% year-over-year growth compared to Q1 2023[10] - The company's total revenue increased by 55% year-over-year, reaching $494 million in Q1 2024[37] - Alnylam is reiterating its full-year 2024 net product revenue guidance of $1400 million to $1500 million, representing a 13% to 21% growth compared to 2023[38] - Non-GAAP operating profit was $2 million, a significant improvement compared to a $110 million loss in Q1 2023[37] - Cash and investments totaled $2371 million as of March 31, 2024[37] Commercial Highlights - AMVUTTRA is a clear market leader in the treatment of hATTR-PN, with over 95% of patients complying with the dosing regimen[14] - U S TTR franchise YoY growth was +35%, driven by demand for AMVUTTRA[13] - OXLUMO YoY growth of +77% driven by strong demand[18] Pipeline Development - Topline results from the HELIOS-B Phase 3 clinical study of Vutrisiran in ATTR amyloidosis patients with cardiomyopathy are expected in late June/early July 2024[21] - Zilebesiran continues to demonstrate the potential to transform the treatment of hypertension[24] - Alnylam plans to file 3 new INDs (Investigational New Drug applications)[40]