Core Points - Amarin Corporation has regained compliance with Nasdaq's continued listing standards for minimum share price, confirming an average closing share price of at least $1.00 over the last 10 consecutive business days as of April 28, 2025 [2][3] - The company is now fully compliant with all Nasdaq listing requirements and will continue to be listed and traded on the Nasdaq Capital Market [3] - Amarin's focus remains on maximizing the global value of its products VASCEPA and VAZKEPA for patients [3] Company Overview - Amarin is an innovative pharmaceutical company specializing in cardiovascular disease management, with offices in Bridgewater, New Jersey, Dublin, Ireland, and Zug, Switzerland, among other locations [3] - The company is committed to enhancing the scientific understanding of cardiovascular risk that persists beyond traditional therapies and advancing treatment options [3]

Group 1 - Amarin Corporation plc will host a conference call on May 7, 2025, at 8:00 a.m. ET to discuss its first quarter 2025 results [1] - The financial results will be released in the pre-market hours on the same day [1] - The call will include a Q&A session with the management team, including President & CEO Aaron Berg [1] Group 2 - Amarin is an innovative pharmaceutical company focused on cardiovascular disease management, with offices in multiple countries including the United States, Ireland, and Switzerland [3] - The company aims to enhance the scientific understanding of cardiovascular risks that persist beyond traditional therapies [3] - Amarin maintains communication with investors through its website and investor relations section, providing access to various materials and updates [4]

DUBLIN and BRIDGEWATER, N.J., April 09, 2025 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ:AMRN), today confirmed that April 11, 2025 will be the effective date for the Company's previously announced Ratio Change on its American Depositary Shares ("ADS") -- an action in which the Company will effect a ratio change from one (1) ADS representing one (1) ordinary share to a new ratio of one (1) ADS representing twenty (20) ordinary shares (the "Ratio Change"). The objective of this action is to increase t ...

DUBLIN, Ireland and BRIDGEWATER, N.J., April 07, 2025 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ:AMRN) today announced the appointment of Michael Torok, Co-Founder and Managing Director of investment firm JEC Capital Partners, as a member of the Board of Directors, effective immediately. “On behalf of the board, I welcome Michael. His financial expertise, experience on other boards and, as a fellow shareholder, his shared priority to continue focusing on strategies to maximize shareholder value, mak ...

– Data Further Advance Understanding of VASCEPA®/VAZKEPA® Potential Mechanism of Action and Utility as A Complementary Therapy for Residual Risk Reduction in Combination with Statins in Important Patient Sub-Categories – DUBLIN and BRIDGEWATER, N.J., March 31, 2025 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ:AMRN) today highlighted key data presentations at ACC.25 showcasing the mechanistic activity of eicosapentaenoic acid (EPA) on lipoprotein(a) [Lp(a)]-enriched plasma and the effects of a glucagon ...

Financial Data and Key Metrics Changes - In Q4 2024, Amarin reported total net revenue of $62.3 million, a decrease from $74.7 million in Q4 2023, with U.S. product revenue dropping to $44.2 million from $64.9 million due to lower net selling prices and decreased volume [33][34] - The company ended 2024 with a strong cash position of $294 million and no debt, reflecting prudent cash management and a focus on strengthening the financial foundation [28][39] Business Line Data and Key Metrics Changes - U.S. product revenue decline was attributed to the loss of CVS commercial exclusivity, leading to a shift in business mix and higher rebates [34][74] - European product revenue increased to $4 million, driven by growth in Spain and the UK, while partnership revenue from the rest of the world rose to $11.9 million, a $7.7 million increase year-over-year [34][35] Market Data and Key Metrics Changes - VASCEPA revenues in Europe gradually increased throughout 2024, with significant contributions from Spain, the UK, and Central Eastern Europe [19] - The company secured pricing and reimbursement in 10 European markets, with ongoing efforts to expand access in various regions [19][20] Company Strategy and Development Direction - The company aims to maintain its NASDAQ listing through an ADS ratio change, which is intended to increase the per-share market price to comply with NASDAQ's minimum bid price requirement [14][43] - Amarin is focused on driving momentum in Europe and the rest of the world, leveraging patent protection until 2039 and exploring opportunities for additional products in the cardiovascular and cardiometabolic areas [63][80] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in generating further momentum in 2025, emphasizing the importance of addressing cardiovascular disease, which remains a leading global health challenge [66][68] - The company acknowledged the challenges posed by the generic market but highlighted the resilience of the U.S. business and the significant untapped potential for VASCEPA globally [30][34] Other Important Information - The company successfully extended its intellectual property position in Europe, enhancing exclusivity for VASCEPA through 2039 [15] - Amarin has supported over 500 publications to advance the understanding of icosapent ethyl's clinical benefits, which has driven regulatory progress globally [11][48] Q&A Session Summary Question: Factors influencing U.S. net price in Q4 - Management noted that the U.S. market is increasingly generic, with a mix of business changing over time, impacting net prices [72] - The shift in business mix due to CVS commercial moving from exclusive to not covered was a significant driver of the revenue changes [74] Question: Outlook on building the pipeline - Management indicated a focus on executing with VASCEPA while remaining opportunistic regarding business development, particularly in cardiovascular and cardiometabolic areas [78][80] Question: Driving rest of the world revenue growth - Management highlighted that they are early in most regions, with ongoing efforts to establish medical advocacy and access, particularly in China and Australia [84][90]

Financial Data and Key Metrics Changes - In 2024, the company reported total revenues of $228.6 million, with a cash position of $294 million and no debt, indicating a strong financial foundation [7][20] - The fourth quarter of 2024 saw total net revenue of $62.3 million, a decrease from $74.7 million in the same quarter of 2023, primarily due to lower net selling prices and decreased volume [22][23] - The GAAP net loss for Q4 2024 was $48.6 million, compared to a loss of $5.8 million in the prior year, largely due to the impact of generic competition [26] Business Line Data and Key Metrics Changes - U.S. product revenue in Q4 2024 was $44.2 million, down from $64.9 million in Q4 2023, affected by lower selling prices and volume declines [23][24] - European product revenue increased to $4 million, driven by growth in Spain and the UK, marking a $2.5 million increase year-over-year [24] - Revenue from partnerships in the rest of the world reached $11.9 million, a $7.7 million increase compared to the previous year, reflecting ongoing market launches [25] Market Data and Key Metrics Changes - The company has secured approvals for Vascepa in 49 markets globally, with ongoing efforts to establish pricing and reimbursement agreements [8][9] - In Europe, the commercialization strategy has led to increased revenues, particularly in Spain, the UK, and Central Eastern Europe [12][13] - The U.S. market continues to show resilience, with 74% of the Vascepa branded business coming from exclusives, covering approximately 43 million lives [14] Company Strategy and Development Direction - The company aims to maintain its NASDAQ listing through an ADS ratio change, reflecting its commitment to realizing the full value potential of Amarin [10][30] - Strategic focus includes expanding Vascepa's market presence in Europe and other regions, leveraging patent protection until 2039 [42] - Continued investment in research to enhance understanding of Vascepa's therapeutic value and its role in reducing cardiovascular risk is a priority [43] Management's Comments on Operating Environment and Future Outlook - Management acknowledges the challenges posed by the generic market but remains optimistic about the untapped potential of Vascepa globally [21][41] - The company is focused on driving momentum in Europe and maximizing profitability in the U.S. while maintaining financial discipline [42][44] - There is a strong belief in the product's value as a complementary therapy to existing lipid-lowering treatments, addressing residual cardiovascular risk [36][39] Other Important Information - The company has successfully reduced operating expenses by 26% year-over-year, reflecting ongoing cost optimization initiatives [20][26] - The ADS ratio change is intended to comply with NASDAQ's minimum bid price requirement, ensuring continued access to public equity capital markets [30][31] Q&A Session Summary Question: Factors influencing U.S. net price in Q4 - Management noted that the U.S. market is increasingly generic, with a mix of business that fluctuates, impacting net prices [49][50] - The shift in business mix due to CVS moving from exclusive to not covered has led to higher rebates and volume impacts [52] Question: Outlook on building the pipeline - The company remains focused on executing with Vascepa while being opportunistic about potential business development opportunities in cardiovascular and cognitive metabolic areas [56][57] Question: Driving revenue growth in the rest of the world - Management highlighted that they are early in the launch phase in many regions, with ongoing efforts to establish medical advocacy and access [61][63]

Regulatory Approvals and Market Access - VASCEPA has received regulatory approval under the REDUCE-IT indication in 49 countries, including the U.S. and 27 EU Member States[445] - In Mainland China, VASCEPA received approval under the MARINE indication on June 1, 2023, and under the REDUCE-IT indication on June 28, 2024[460] - The company has filed 19 dossiers to gain market access in European countries, with reimbursement being a requisite for commercial success[454] - VASCEPA has been launched commercially in Canada since February 2020, with reimbursement obtained from all major private and public payors[462] - The company has received marketing authorization from the Medicines and Healthcare Products Regulatory Agency for VAZKEPA in England, Wales, and Scotland[445] - The company has filed for regulatory review in 22 countries and regions and received approval in 15 countries and regions outside of the U.S. and EMA, including Mainland China, Switzerland, Australia, New Zealand, and Israel[463] - The company entered into agreements with CSL Seqirus for commercialization in Australia and New Zealand, and with Lotus Pharmaceuticals for South Korea and Southeast Asia, expanding its market presence[464] - In the MENA region, VASCEPA has been launched in several countries, including Lebanon and the United Arab Emirates, with ongoing registration in additional countries[461] Sales and Revenue Performance - Approximately 27 million estimated normalized total prescriptions of VASCEPA have been reported since its commercial launch in 2013[447] - Product revenue is primarily derived from VASCEPA sales, with revenues recognized upon delivery to distributors, and the net price for direct sales being significantly higher than sales to commercial partners[475] - Total revenue, net decreased by $78.3 million, or 26%, to $228.6 million in 2024 from $306.9 million in 2023[499] - Product revenue, net fell by $80.7 million, or 28%, to $204.6 million in 2024, primarily due to a 39% decrease in VASCEPA sales in the U.S.[501] - U.S. product revenue, net decreased to $166.7 million in 2024 from $273.9 million in 2023, impacted by generic competition and a loss of a major Pharmacy Benefit Manager[502] - The overall icosapent ethyl market in the U.S. decreased by 2% in 2024, with the company's market share dropping to approximately 53% from 57%[503] - Product revenue, net from Europe increased to $13.7 million in 2024 from $3.3 million in 2023, primarily from the UK and Spain[504] - Licensing and royalty revenue includes upfront payments and milestone payments related to distribution agreements for VASCEPA outside the U.S.[476] - Licensing and royalty revenue increased by $2.4 million, or 11%, to $24.0 million in 2024[506] Financial Performance and Expenses - The Organizational Restructuring Program resulted in a 30% reduction in the total employee base, leading to an annual operating cost reduction of $50 million[467] - Research and development expenses include costs for clinical trials, independent monitoring, and salaries, with expenses recognized as incurred[479] - Selling, general and administrative expenses decreased by $47.6 million, or 24%, from $199.9 million in 2023 to $152.3 million in 2024[512] - Research and development expenses decreased by $1.4 million, or 6%, from $22.2 million in 2023 to $20.9 million in 2024[513] - Restructuring expenses from the July 2023 ORP included severance pay and other related costs[480] - Restructuring expenses were nil in 2024 compared to $11.0 million in 2023, reflecting a 100% decrease due to the implementation of the ORP[515] - Cost of goods sold rose by $5.9 million, or 4%, to $147.2 million in 2024, reflecting increased costs associated with supply management and inventory[508] - Approximately $8.0 million of inventory was expensed in 2024 due to unsellable inventory, compared to $5.1 million in 2023[509] - Overall gross margin on product sales decreased to 28% in 2024 from 50% in 2023, with a gross margin of 50% and 66% when excluding restructuring inventory and write-off charges[511] Cash Flow and Liquidity - Cash and cash equivalents and short-term investments totaled $294.5 million as of December 31, 2024[519] - Net cash used in operating activities was $(31.0) million in 2024, a decrease from $6.9 million provided in 2023[520] - The accumulated deficit as of December 31, 2024, was $1.7 billion, with expectations of variable quarterly net cash outflows due to various factors[524] - The company has no indebtedness and believes its liquidity will be sufficient to fund projected operations for at least one year[527] - A share repurchase program was announced to purchase up to $50.0 million of the company's ordinary shares, pending market conditions[526] Clinical and Research Developments - VASCEPA is the first and only drug approved by the U.S. FDA as an adjunct to maximally tolerated statin therapy for reducing persistent cardiovascular risk in select high-risk patients[445] - The REDUCE-IT study has been pivotal, with over 50 clinical treatment guidelines recognizing the use of icosapent ethyl for cardiovascular risk reduction[469] - The company continues to evaluate its deferred tax assets, concluding that they are not likely to be realizable as of December 31, 2024 and 2023[494] - Interest income, net, increased by $1.5 million, or 13%, from $11.9 million in 2023 to $13.4 million in 2024[516]

Financial Performance - Total revenues for Q4 2024 were $62.3 million, a decrease of 17% compared to $74.7 million in Q4 2023[8] - Operating expenses for Q4 2024 were $43.0 million, down 18% from $49.7 million in Q4 2023[8] - The company reported a net loss of $48.6 million for Q4 2024, compared to a net loss of $5.8 million in Q4 2023[11] - Adjusted net loss for Q4 2024 was $8.7 million, compared to an adjusted net loss of $0.9 million in Q4 2023[12] - Non-GAAP adjusted net loss for Q4 2024 was $8.744 million, compared to a loss of $0.906 million in Q4 2023[36] - Product revenue for the year ended December 31, 2024, was $204.590 million, a decrease of 28.3% from $285.299 million in 2023[34] - Gross margin for the year ended December 31, 2024, was $81.382 million, down from $165.541 million in 2023[34] - Net loss for the year ended December 31, 2024, was $82.183 million, compared to a loss of $59.112 million in 2023[34] - Operating loss for Q4 2024 was $52.522 million, compared to a loss of $4.837 million in Q4 2023[34] Cash Position and Assets - The company ended 2024 with a cash position of $294.2 million, an 8% decrease from $320.7 million at the end of 2023[8] - Cash and cash equivalents decreased to $121.038 million as of December 31, 2024, from $199.252 million a year earlier[32] - Total assets as of December 31, 2024, were $685.349 million, down from $831.684 million in 2023[32] - Total stockholders' equity decreased to $486.176 million as of December 31, 2024, from $552.097 million in 2023[32] Revenue Breakdown - U.S. net product revenue for Q4 2024 was $44.2 million, compared to $64.9 million in Q4 2023, reflecting a significant decline[14] - European net product revenue increased to $4.0 million in Q4 2024 from $1.5 million in Q4 2023, showing growth in that market[14] - Total revenue for Q4 2024 was $62.306 million, down 16.5% from $74.713 million in Q4 2023[34] Strategic Plans - The company plans to implement a 1-for-20 ADS ratio change to maintain its Nasdaq listing, effective around April 11, 2025[4] - The VASCEPA/VAZKEPA franchise is expanding into six additional global markets, including Italy, China, and Australia[3] - The company aims to capitalize on the significant opportunity in Europe, targeting over 5 million high-risk patients with established cardiovascular disease[15] - The company plans to expand access and reimbursement for VAZKEPA across global markets, with expectations for strategic collaborations in 2025[27]

Core Points - Amarin Corporation plans to change the ratio of its American Depositary Shares (ADS) from 1:1 to 1:20 to comply with Nasdaq's minimum bid price requirement of $1.00 per share [1][3] - The effective date for this ratio change is expected to be around April 11, 2025 [1] - The adjustment will not affect the ordinary shares of Amarin, and the ADSs will continue to trade under the symbol "AMRN" on The Nasdaq Capital Market [2] Summary by Sections Ratio Change Details - The ratio change aims to increase the per share market price of the Company's ADSs to maintain its listing on Nasdaq [3] - Holders of uncertificated ADSs will not need to take action as the exchange will occur automatically, while registered holders of certificated ADSs must surrender their shares for the new ratio [3][4] - No fractional new ADSs will be issued; instead, fractional entitlements will be aggregated and sold, with net cash proceeds distributed to ADS holders [4] Market Impact - The trading price of the Company's ADSs is expected to increase proportionally due to the ratio change, although there is no assurance that the price will be equal to or greater than twenty times the pre-adjustment price [5] Company Overview - Amarin is an innovative pharmaceutical company focused on cardiovascular disease management and aims to enhance the understanding and treatment of cardiovascular risks [6]