Core Insights - Actinium Pharmaceuticals has presented promising preclinical results for ATNM-400, a novel targeted radiotherapy for prostate cancer, indicating its potential as a transformative treatment option for patients with unmet clinical needs following Pluvicto therapy [1][7] Group 1: Efficacy and Mechanism - ATNM-400 demonstrated a 99.8% tumor growth inhibition with a single 40 µCi/kg dose in prostate cancer models, outperforming Pluvicto [1][6] - In vivo studies showed a statistically significant (p < 0.0001) reduction in tumor volume in 22Rv1 prostate cancer models, highlighting its transformative therapeutic potential [2][5] - The drug exhibited robust antitumor activity in mice with Pluvicto-resistant tumors, administered 14 days post-Pluvicto treatment [3][6] Group 2: Targeting and Safety - ATNM-400 targets a distinct non-PSMA receptor that is highly expressed in metastatic castration-resistant prostate cancer (mCRPC), maintaining expression levels even after Pluvicto treatment [4][7] - The Ac-225 isotope used in ATNM-400 is more potent than Lu-177, capable of causing lethal double-stranded DNA breaks, and has a shorter path length, potentially resulting in fewer off-target effects [4][10] - ATNM-400 was well tolerated in studies, showing no apparent toxicities and efficient clearance from essential organs [10] Group 3: Market Context and Future Outlook - Pluvicto, marketed by Novartis, generated sales of $1.39 billion in 2024, indicating a significant market for prostate cancer therapies [1] - The company anticipates increased demand for therapies addressing patients who progress after Pluvicto, especially following its recent approval in earlier treatment settings [7] - Actinium is committed to advancing ATNM-400's development, with additional data expected later this year [7]

Core Viewpoint - The Gross Law Firm has issued a notice to shareholders of Actinium Pharmaceuticals, Inc. regarding a class action lawsuit related to misleading statements and omissions concerning the company's Iomab-B BLA application to the FDA [1][2]. Group 1: Allegations - The complaint alleges that during the class period from October 31, 2022, to August 2, 2024, the defendants made materially false and misleading statements regarding the company's Phase 3 Sierra trial data [2]. - It is claimed that the data from the Sierra trial was unlikely to meet FDA guidelines for the acceptance and approval of the Iomab-B BLA [2]. - The additional analyses provided to the FDA, which suggested improved Overall Survival, were also unlikely to satisfy FDA requirements [2]. - As a result of these issues, the FDA was expected to refuse to review the Iomab-B BLA or find it unlikely to approve the application in its current form [2]. - The defendants' positive statements about the company's business and prospects were deemed materially misleading and lacked a reasonable basis [2]. Group 2: Next Steps for Shareholders - Shareholders who purchased shares of ATNM during the specified class period are encouraged to register for the class action by May 27, 2025 [3]. - Upon registration, shareholders will be enrolled in a portfolio monitoring system to receive updates on the case [3]. - There is no cost or obligation for shareholders to participate in this class action [3]. Group 3: Law Firm Background - The Gross Law Firm is a nationally recognized class action law firm dedicated to protecting the rights of investors affected by deceit and illegal business practices [4]. - The firm aims to ensure companies adhere to responsible business practices and seeks recovery for investors who suffered losses due to misleading statements [4].

Core Viewpoint - Faruqi & Faruqi, LLP is investigating potential claims against Actinium Pharmaceuticals, Inc. due to allegations of violations of federal securities laws related to misleading statements about the company's Iomab-B BLA application and its clinical trial data [3][5]. Group 1: Legal Investigation - The firm is encouraging investors who suffered losses in Actinium between October 31, 2022, and August 2, 2024, to discuss their legal rights [1]. - A federal securities class action has been filed against Actinium, with a deadline of May 26, 2025, for investors to seek the role of lead plaintiff [3]. Group 2: Allegations Against Actinium - The complaint alleges that Actinium and its executives made false or misleading statements regarding the likelihood of FDA approval for the Iomab-B BLA based on the Sierra Trial data [5]. - It is claimed that the additional analyses provided to the FDA were unlikely to satisfy the agency's guidelines, which could lead to a refusal to review or approve the BLA [5]. Group 3: Stock Price Impact - Following the release of a press statement on August 5, 2024, which indicated the need for an additional clinical trial, Actinium's stock price fell by $3.69, or nearly 60%, closing at $2.48 [6][7].

NEW YORK, April 25, 2025 /PRNewswire/ -- Levi & Korsinsky, LLP notifies investors in Actinium Pharmaceuticals, Inc. ("Actinium" or the "Company") (NYSE: ATNM) of a class action securities lawsuit.CLASS DEFINITION: The lawsuit seeks to recover losses on behalf of Actinium investors who were adversely affected by alleged securities fraud between October 31, 2022 and August 2, 2024. Follow the link below to get more information and be contacted by a member of our team:https://zlk.com/pslra-1/actinium-lawsuit-s ...

NEW YORK, April 23, 2025 (GLOBE NEWSWIRE) -- The Gross Law Firm issues the following notice to shareholders of Actinium Pharmaceuticals, Inc. (NYSE: ATNM). Shareholders who purchased shares of ATNM during the class period listed are encouraged to contact the firm regarding possible lead plaintiff appointment. Appointment as lead plaintiff is not required to partake in any recovery. CONTACT US HERE: https://securitiesclasslaw.com/securities/actinium-loss-submission-form/?id=144420&from=3 CLASS PERIOD: Octobe ...

NEW YORK  , April 22, 2025 /PRNewswire/ -- Levi & Korsinsky, LLP notifies investors in Actinium Pharmaceuticals, Inc. ("Actinium" or the "Company") (NYSE: ATNM) of a class action securities lawsuit.CLASS DEFINITION: The lawsuit seeks to recover losses on behalf of Actinium investors who were adversely affected by alleged securities fraud between October 31, 2022 and August 2, 2024. Follow the link below to get more information and be contacted by a member of our team:https://zlk.com/pslra-1/actinium-lawsuit ...

NEW YORK, April 21, 2025 (GLOBE NEWSWIRE) -- Levi & Korsinsky, LLP notifies investors in Actinium Pharmaceuticals, Inc. ("Actinium" or the "Company") (NYSE: ATNM) of a class action securities lawsuit. CLASS DEFINITION: The lawsuit seeks to recover losses on behalf of Actinium investors who were adversely affected by alleged securities fraud between October 31, 2022 and August 2, 2024. Follow the link below to get more information and be contacted by a member of our team: https://zlk.com/pslra-1/actinium-law ...

NEW YORK, April 21, 2025 /PRNewswire/ -- The Gross Law Firm issues the following notice to shareholders of Actinium Pharmaceuticals, Inc. (NYSE: ATNM).Shareholders who purchased shares of ATNM during the class period listed are encouraged to contact the firm regarding possible lead plaintiff appointment. Appointment as lead plaintiff is not required to partake in any recovery.CONTACT US HERE:https://securitiesclasslaw.com/securities/actinium-loss-submission-form/?id=143830&from=4 CLASS PERIOD: October 31, 2 ...

Core Viewpoint - A class action lawsuit has been filed against Actinium Pharmaceuticals, Inc. for allegedly misleading investors regarding the approval prospects of its Biologics License Application for lomab-B, leading to significant stock price decline [1][4]. Summary by Relevant Sections Class Action Lawsuit - The lawsuit is filed in the U.S. District Court for the Southern District of New York on behalf of investors who acquired Actinium securities from October 31, 2022, to August 2, 2024, with a deadline of May 27, 2025, for lead plaintiff applications [1]. Regulatory Update and Stock Performance - On August 5, 2024, Actinium announced that the FDA required an additional clinical study to support its BLA for lomab-B, resulting in a stock price drop of $3.69, or approximately 59%, from $6.17 to $2.48 per share [3]. Allegations of Misleading Information - The complaint alleges that during the Class Period, Actinium misled the market into believing that the data submitted for its BLA would meet FDA guidelines for acceptance and approval [4].

NEW YORK, April 18, 2025 (GLOBE NEWSWIRE) -- Levi & Korsinsky, LLP notifies investors in Actinium Pharmaceuticals, Inc. ("Actinium" or the "Company") (NYSE: ATNM) of a class action securities lawsuit. CLASS DEFINITION: The lawsuit seeks to recover losses on behalf of Actinium investors who were adversely affected by alleged securities fraud between October 31, 2022 and August 2, 2024. Follow the link below to get more information and be contacted by a member of our team: https://zlk.com/pslra-1/actinium-law ...