Eledon is currently conducting a Phase 2 trial (BESTOW; NCT05983770), a Phase 1b trial (NCT05027906), and a long-term safety and efficacy extension study (NCT06126380) to evaluate tegoprubart for the prevention of organ rejection in patients receiving a kidney transplant. "As of this week, we have already enrolled two-thirds of the projected study participants across sites in the United States, Europe and Latin America," said David-Alexandre C. Gros, M.D., Chief Executive Officer of Eledon. "We are grateful ...

Eledon Pharmaceuticals, Inc. is a clinical stage biotechnology company that is developing immune-modulating therapies for the management and treatment of life-threatening conditions. The Company's lead investigational product is tegoprubart, an anti-CD40L antibody with high affinity for CD40 Ligand, a well-validated biological target within the costimulatory CD40/CD40L cellular pathway. The central role of CD40L signaling in both adaptive and innate immune cell activation and function positions it as an att ...

分组1: Tilray Brands - The cannabis industry is experiencing significant interest following the DEA's proposal to reschedule marijuana to a Schedule Three controlled substance, positioning Tilray Brands to benefit from potential U.S. market expansion [3][6] - Tilray has reported a 30% year-over-year revenue increase, with positive sales across its cannabis, distribution, and alcohol segments [4] - Despite facing challenges, including a bankruptcy in its portfolio affecting U.S. expansion plans, Tilray is reassessing its strategy and remains optimistic about future opportunities [5][6] 分组2: Rigel Pharmaceuticals - Rigel Pharmaceuticals is focused on developing treatments for hematologic disorders and cancer, with two FDA-approved products: Tavalisse for chronic immune thrombocytopenia and Rezlidhia for acute myeloid leukemia [8][9] - Tavalisse generated $21.1 million in net product sales last quarter, while Rezlidhia contributed $4.9 million, indicating a solid revenue stream [9] - The company has reduced its net loss by $5.3 million compared to the previous year and is actively sharing promising data from its pipeline, enhancing investor confidence [10][11] 分组3: Eledon Pharmaceuticals - Eledon Pharmaceuticals is dedicated to improving organ transplant success rates and is developing Tegoprubart to prevent rejection in kidney transplant patients [13][14] - The company reported a flat net loss year-over-year but secured $50 million in gross proceeds from private placement financing, supporting ongoing research and development [15] - Eledon is nearing the completion of patient enrollment for phase 2 trials of Tegoprubart, indicating potential for significant advancements in the near future [14][15] 分组4: Market Outlook - The three highlighted penny stocks—Tilray Brands, Rigel Pharmaceuticals, and Eledon Pharmaceuticals—are positioned for growth due to their innovative products and favorable market conditions, despite inherent risks [18]

Core Insights - Eledon Pharmaceuticals presented updated data from its ongoing Phase 1b trial of tegoprubart, showing promising safety and efficacy in preventing organ rejection in kidney transplant patients [1][2][3] Group 1: Clinical Trial Results - The overall mean estimated glomerular filtration rate (eGFR) after day 30 post-transplant was reported at 70.5 mL/min/1.73m², with mean eGFR above 60 mL/min/1.73m² at all reported time points [1][2] - Historical studies indicate that standard calcineurin inhibitor-based immunosuppression typically results in mean eGFRs of approximately 50 mL/min/1.73m² during the first year post-transplant, while tegoprubart showed mean eGFRs above 90 mL/min/1.73m² in two participants after one year [2][3] Group 2: Safety Profile - Tegoprubart demonstrated a generally safe and well-tolerated profile, with no cases of hyperglycemia, new onset diabetes, or tremor reported, which are common side effects of standard immunosuppression therapies [3] - Three subjects discontinued the study due to hair loss and fatigue, viral infection, and rejection, but there were no cases of graft loss or death [3] Group 3: Future Developments - Eledon is conducting a Phase 1b trial, a Phase 2 trial (BESTOW), and a long-term safety and efficacy extension study to further evaluate tegoprubart for kidney transplant patients [4][5] - The company anticipates completing enrollment in the Phase 2 BESTOW trial by the end of the year [2]

Core Insights - Eledon Pharmaceuticals presented updated data on tegoprubart, an anti-CD40L antibody, at the American Transplant Congress, indicating its potential for preventing organ rejection in kidney transplant patients [1][2] - The ongoing Phase 1b trial shows promising results, with an overall mean estimated glomerular filtration rate (eGFR) of 70.5 mL/min/1.73m² after day 30 post-transplant, significantly higher than the typical 50 mL/min/1.73m² reported with standard calcineurin inhibitor therapies [2][3] Company Overview - Eledon Pharmaceuticals is a clinical-stage biotechnology company focused on developing immune-modulating therapies for life-threatening conditions, with tegoprubart as its lead investigational product [5] - The company is conducting multiple clinical trials, including a Phase 1b trial, a Phase 2 trial (BESTOW), and a long-term safety and efficacy extension study [4] Clinical Trial Results - Data from 13 participants in the Phase 1b trial indicate that tegoprubart is generally safe and well tolerated, with no cases of hyperglycemia, new onset diabetes, or tremor reported [3] - Two participants who completed 12 months on therapy post-transplant demonstrated mean eGFRs above 90 mL/min/1.73m², further supporting the drug's efficacy [2] Future Plans - The company aims to continue accruing data from the ongoing Phase 1b and open-label extension studies while also enrolling participants in the Phase 2 BESTOW trial, with completion expected by the end of the year [2]

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UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36620 ELEDON PHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 20-1000967 (State or other jurisdiction of incorporation or organization) 19800 MacArthur Blvd., Suite 250 Irvine, California 92612 (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SEC ...

The change in a company's future earnings potential, as reflected in earnings estimate revisions, and the near- term price movement of its stock are proven to be strongly correlated. That's partly because of the influence of institutional investors that use earnings and earnings estimates for calculating the fair value of a company's shares. An increase or decrease in earnings estimates in their valuation models simply results in higher or lower fair value for a stock, and institutional investors typically ...

EXHIBIT 99.1 Eledon Pharmaceuticals Reports First Quarter 2024 Operating and Financial Results Completed oversubscribed $50 million private placement First participant dosed in clinical trial at University of Chicago Medicine assessing the use of tegoprubart to prevent islet cell transplant rejection in patients with type 1 diabetes Reported updated data from ongoing Phase 1b trial evaluating tegoprubart for prevention of rejection in kidney transplantation Tegoprubart used as part of immunosuppressive trea ...