NASDAQ: LNTH Lantheus Investor Presentation Building on our Foundation to Power the Future of Radiopharmaceuticals May 2025 © 2025 Lantheus. All rights reserved. Safe Harbor Statements Cautionary Statement Regarding Forward-Looking Statements This document contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, that are subject to risks and uncertainties and are made pursuant to the safe harbor provisions of Section 27A of the Securities Ac ...

Summary of Lantheus Conference Call Company Overview - **Company**: Lantheus - **Industry**: Radiopharmaceuticals - **Key Executives**: Brian Markison (CEO), Bob Marshall (CFO) [1][2] Core Business and Products - Lantheus is focused on molecular imaging and aims to improve patient outcomes through its products [3] - **Key Products**: - **Polarify**: A leading PSMA imaging agent with sales of $1.58 billion last year, showing strong first-quarter sales [6] - **Definity**: A stable growth asset with first-quarter sales of nearly $80 million, expected to grow to $600 million annually by the end of the decade [8][9] - **Octavvy**: Recently acquired diagnostic product aimed at neuroendocrine tumors, expected to launch in mid-next year [22][23] Market Dynamics - The Total Addressable Market (TAM) for PSMA imaging is growing at an estimated rate of 15% to 20% annually, with a focus on earlier lines of prostate cancer therapy [7] - The TAM for Definity is projected to reach $600 million by the end of the decade, with a return to steady growth rates [10] Pipeline and Future Developments - Lantheus has a robust pipeline, including: - **MK-6240**: A tau imaging agent for Alzheimer's disease, with a TAM of approximately $1.5 billion by the end of the decade [12][13] - **NAV**: A second-generation beta amyloid product expected to outperform existing agents [18][19] - **GRPR**: A diagnostic and therapeutic agent for prostate cancer, currently in phase two trials [26][29] Financial Outlook - The company anticipates a pathway to double-digit top-line growth by 2026, driven by stabilization of Polarify, divestiture of the spec business, and new product launches [43][44] - The divestiture of the spec business, valued at $120 million, is expected to unlock additional growth potential [45] Strategic Insights - Lantheus is positioned to capitalize on the growing demand for imaging in Alzheimer's and prostate cancer, with a focus on innovative products that enhance diagnostic capabilities [12][20] - The company is actively pursuing partnerships to accelerate the development of its pipeline assets [35][36] Conclusion - Lantheus is strategically positioned in the radiopharmaceutical industry with a diverse product portfolio and a strong pipeline aimed at addressing significant medical needs in imaging and therapeutics [41][42]

Commercial Portfolio Performance - PYLARIFY achieved blockbuster status in 2024 with over $1 billion in sales[154], and Q1 2025 net sales reached $257.7 million[13] - DEFINITY remains the 1 utilized ultrasound enhancing agent, with Q1 2025 net sales of $79.2 million, a 3.5% year-over-year growth[24] Market Opportunities - The U S PSMA PET imaging market has a potential of over $3.5 billion by 2030, driven by expansion of radiotherapeutics and increasing clinical utility in BCR population[19, 20] - The U S ultrasound enhancing agent total addressable market is over $600 million[35] Pipeline Development - Lantheus is advancing an innovative pipeline of radiopharmaceuticals, including diagnostic and therapeutic candidates for prostate cancer, neuroendocrine tumors, and Alzheimer's disease[38, 40] - LNTH-2402, a GRPR-targeted radiotherapeutic, is expected to have an IND filing in Q4 2025, with Phase 1 initiation planned for 2026[109] Financial Highlights - As of March 31, 2025, Lantheus had $938.5 million in cash on hand and $98.8 million in free cash flow in Q1 2025[10] - The updated interim corporate financial guidance for the full year 2025 projects revenue between $1.550 billion and $1.585 billion, and adjusted fully diluted EPS between $6.60 and $6.70[142] Strategic Transactions - The acquisition of Evergreen Theragnostics closed in April 2025, strengthening radiodiagnostic and therapeutic capabilities[10, 165] - The acquisition of Life Molecular Imaging is expected to close by 2Q 2025, expanding the commercial portfolio and pipeline in Alzheimer's disease[10, 144]

Core Insights - Lantheus Holdings, Inc. is set to present new data on two oncology radiodiagnostic agents at the 2025 Society of Nuclear Medicine and Molecular Imaging Annual Meeting, highlighting its commitment to improving patient outcomes through advanced radiopharmaceuticals [1][12]. Presentation Details - Oral presentations will include the optimized production and quality control of the FAP imaging agent [64Cu]LNTH-1363S, presented by Gengyang Yuan on June 24, 2025 [2]. - Poster presentations will cover topics such as the positive predictive value of 18F-Piflufolastat PET/CT in recurrent prostate cancer and the first clinical evaluation of 68Ga-LNTH-1363S for PET imaging [2]. Product Information - PYLARIFY® (piflufolastat F 18) is a PSMA-targeted PET imaging agent that allows visualization of metastatic prostate cancer, with a recommended dose of 333 MBq (9 mCi) [3][4]. - PYLARIFY has been utilized in over 500,000 scans across the U.S., making it the most ordered PSMA PET imaging agent [3]. Company Overview - Lantheus is a leading company in the radiopharmaceutical sector, with nearly 70 years of experience in providing solutions that enhance disease detection and treatment [12].

Summary of Lantheus (LNTH) FY Conference Call - June 10, 2025 Company Overview - Lantheus has been in the nuclear medicine business since 1956, known for its PSMA imaging agent, Polarify, for prostate cancer [3][4] - The company operates in significant growth markets including cancer, neurodegenerative diseases (specifically Alzheimer's), therapeutic oncology, diagnostic oncology, and cardiology [4] Market Dynamics - The PSMA imaging market is experiencing growth between 15% to 20% [6] - Recent entrants in the market include LU6 and Postluma, which are affecting competitive dynamics [6] - The reimbursement environment has been inconsistent, with Lantheus losing pass-through status and transitioning to MUC pricing for Medicare outpatient services [6][7] - Speculation exists regarding future CMS decisions on pricing models, with potential impacts on Lantheus and Polarify [7][8] Competitive Landscape - Lantheus is seeing volume growth despite a challenging market environment, with expectations of a "lumpy" year until the market stabilizes [8][10] - Competitors like Pulse Luma have pricing advantages but also face issues with false positives in scans [9] - The company is focusing on expanding its presence in smaller accounts to drive adoption [12][37] Future Outlook - The outlook for Polarify pricing is uncertain, but Lantheus expects to return to market-level growth as competitive dynamics stabilize [11][12] - The company anticipates growth in smaller accounts, which are beginning to increase scan volumes significantly [12][13] - There is a noted bottleneck in large institutions, creating opportunities for smaller centers to increase their scan volumes [12][14] International Expansion - Lantheus is partnered with Curium for the sale of Polarify in Europe, with plans for expansion into Japan and discussions regarding China [28][30] - The U.S. remains the primary market, but international opportunities are being explored [28][29] Government and Reimbursement Exposure - Approximately 20% of Lantheus's patient population is exposed to government reimbursement changes, with strategic contracts in place to mitigate impacts [33][35] - The potential shift to ASP pricing could create a more level playing field among competitors [32][36] Recent Acquisitions and Synergies - The acquisition of Evergreen is expected to generate synergies quickly, particularly with the launch of Octavy, a diagnostic agent for neuroendocrine tumors [39][40] - The company is focusing on integrating its radioligand therapy pipeline with its manufacturing capabilities [40][41] Pipeline and Growth Drivers - Lantheus has a robust pipeline, including assets for Alzheimer's dementia and radioligand therapies, which are expected to drive significant growth [50][52] - The company is optimistic about the potential of its tau imaging agents, which could become increasingly important in the future [66][68] Portfolio Management - Lantheus is simplifying its organization by divesting non-core assets, such as its spec business, to focus on innovation and growth in its imaging and therapeutic segments [72][73] - The divestiture is expected to improve gross margins and allow for a more focused strategy on new assets [73] Cardiology Opportunities - Lantheus is not actively pursuing cardiology opportunities but acknowledges the potential in collaboration with GE, which is managing the program [75][76] This summary captures the key points discussed during the Lantheus FY Conference Call, highlighting the company's market position, competitive landscape, future outlook, and strategic initiatives.

Core Viewpoint - Lantheus Holdings, Inc. is set to present at the 2025 Truist Securities MedTech Conference, highlighting its commitment to improving patient outcomes through radiopharmaceutical solutions [1]. Company Overview - Lantheus is a leading company in the radiopharmaceutical sector, focused on enabling clinicians to Find, Fight, and Follow disease for better patient outcomes [3]. - The company has been providing radiopharmaceutical solutions for nearly 70 years and is headquartered in Massachusetts, with additional offices in New Jersey, Canada, Sweden, and Switzerland [3]. Event Details - Brian Markison, the Chief Executive Officer of Lantheus, will present at the conference on June 17, 2025, at 8:40 a.m. ET [1]. - A live webcast of the presentation will be accessible through the Investors section of the company's website, with a replay available for at least 30 days post-event [2].

Core Viewpoint - Lantheus Holdings, Inc. is set to present at the Goldman Sachs 46th Annual Global Healthcare Conference 2025, highlighting its commitment to improving patient outcomes through radiopharmaceuticals [1]. Company Overview - Lantheus is a leading company in the radiopharmaceutical sector, focused on enabling clinicians to Find, Fight, and Follow disease for better patient outcomes [3]. - The company has been providing radiopharmaceutical solutions for nearly 70 years and is headquartered in Massachusetts, with additional offices in New Jersey, Canada, and Sweden [3]. Event Details - Brian Markison, the Chief Executive Officer of Lantheus, will present at the conference on June 10, 2025, at 2:40 p.m. ET [1]. - A live webcast of the presentation will be accessible on the company's website, with a replay available for at least 30 days post-event [2].

Group 1 - Lantheus (NASDAQ: LNTH) shares experienced a significant decline of 25% following the release of its Q1 2025 report, indicating a disappointment in market expectations [1] - The company has reduced its earnings per share (EPS) guidance for 2025, which is attributed to costs associated with mergers and acquisitions (M&A) and the divestiture of a low-growth segment [1]

Core Viewpoint - Investors should focus on pharmaceutical stocks that are currently trading at extremely oversold levels, as indicated by the Relative Strength Index (RSI), which can signal potential rebounds [1][13]. Group 1: Sarepta Therapeutics - Sarepta Therapeutics has an RSI of 22, indicating extreme oversold conditions, and has seen its stock price drop over 40% following an earnings miss [2][3]. - The 12-month stock price forecast for Sarepta is $131.22, suggesting a potential upside of 262.48% from the current price of $36.20 [2]. - Analysts, including those from Wells Fargo, maintain a Buy rating and are optimistic about Sarepta's long-term pipeline, particularly its FDA-approved gene therapy for Duchenne muscular dystrophy [3][4]. Group 2: Krystal Biotech - Krystal Biotech's RSI has risen to 33, indicating a recovery from oversold levels, with a recent stock price of $134.53 [5][6]. - The 12-month stock price forecast for Krystal is $218.63, representing a potential upside of 62.51% [5]. - Analysts remain bullish on Krystal, with Guggenheim reiterating a Buy rating and a price target of $189, indicating nearly 40% upside potential [7][8]. Group 3: Lantheus Holdings - Lantheus Holdings has an RSI of 28, showing signs of being oversold after a 25% drop following an earnings miss [9][10]. - The 12-month stock price forecast for Lantheus is $132.67, suggesting a potential upside of 68.04% from the current price of $78.95 [9]. - Truist Financial has reiterated a Buy rating with a price target of $117, indicating more than 45% upside potential, supported by the company's strong product portfolio [11][10].

LOS ANGELES, May 8, 2025 /PRNewswire/ -- The DJS Law Group announces that it is investigating claims on behalf of investors of Lantheus Holdings, Inc. ("Lantheus" or "the Company") (NASDAQ: LNTH) for violations of the securities laws. DJS Law Group INVESTIGATION DETAILS: The investigation focuses on whether the Company issued misleading statements and/or failed to disclose information pertinent to investors. Lantheus reported its financial results for the first quarter of 2025 on May 7, 2025. Along wit ...