Lexicon Pharmaceuticals, Inc. (NASDAQ:LXRX) Q3 2021 Earnings Conference Call November 3, 2021 5:00 PM ET Company Participants Chas Schultz - Executive Director of Corporate Communications & Patient Advocacy Lonnel Coats - President and Chief Executive Officer and Director Jeff Wade - Executive Vice President, Corporate and Administrative Affairs and Chief Financial Officer Craig Granowitz - Senior Vice President and Chief Medical Officer. Conference Call Participants Yigal Nochomovitz - Citigroup Jessica Fy ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2021 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from _____________ to _____________ Commission File Number: 000-30111 Lexicon Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) (281) 863 ...

Lexicon Pharmaceuticals, Inc. (NASDAQ:LXRX) Q1 2021 Earnings Conference Call May 6, 2021 6:00 AM ET Company Participants Chas Schultz - Executive Director of Corporate Communications & Patient Advocacy Lonnel Coats - President and Chief Executive Officer and Director Jeff Wade - Executive Vice President, Corporate and Administrative Affairs and Chief Financial Officer Conference Call Participants Jessica Fye - JPMorgan Joseph Stringer - Needham & Company Operator Good morning, good afternoon and good evenin ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2021 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from _____________ to _____________ Commission File Number: 000-30111 Lexicon Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) (State o ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☑ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Fiscal Year Ended December 31, 2020 Code) or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from _____________ to _____________ Commission File Number: 000-30111 Lexicon Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delawar ...

Lexicon Pharmaceuticals, Inc. (NASDAQ:LXRX) Q4 2020 Results Conference Call March 10, 2021 5:00 PM ET Company Participants Chas Schultz - Executive Director of Corporate Communications & Patient Advocacy Lonnel Coats - President and Chief Executive Officer and Director Praveen Tyle - Executive Vice President of Research and Development Jeff Wade - Executive Vice President, Corporate and Administrative Affairs and Chief Financial Officer Conference Call Participants Carly Kenselaar - Citigroup Stephen Will ...

(Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q For the Quarterly Period Ended September 30, 2020 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from _____________ to _____________ Commission File Number: 000-30111 Lexicon Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) (Sta ...

Financial Data and Key Metrics Changes - Lexicon Pharmaceuticals reported net product revenues of $6.5 million for Q3 2020, down from $8.4 million in the same quarter of the previous year, reflecting the sale of XERMELO and related assets [44] - The company recognized a gain of $132.8 million from the sale of XERMELO, resulting in a net income of $82.6 million or $0.71 per diluted share, compared to $226.1 million or $1.95 per diluted share in Q3 2019 [46] - Research and development expenses increased to $40.1 million from $26.7 million year-over-year, while selling, general and administrative expenses decreased to $12 million from $13.9 million [45] Business Line Data and Key Metrics Changes - The company completed the sale of XERMELO and related assets, allowing it to repay its $150 million term loan in full and retire over 90% of its outstanding debt [9][10] - The focus has shifted to advancing LX9211, with plans to initiate Phase 2 clinical trials for diabetic peripheral neuropathic pain and post-herpetic neuralgia [11][12] Market Data and Key Metrics Changes - The worldwide market for neuropathic pain is estimated at approximately $6.4 billion for 2020, expected to grow over 13% annually to $13.2 billion by 2026 [19] - There is a significant unmet need in the neuropathic pain market, with an estimated 12 million people suffering from diabetic peripheral neuropathic pain and 600,000 from post-herpetic neuralgia by 2026 [20] Company Strategy and Development Direction - The company aims to operate as a more streamlined and focused entity, with a substantial reduction in expected cash burn moving into 2021 [11][12] - Lexicon plans to engage with the FDA to establish a clear pathway for the approval of sotagliflozin in type 1 diabetes, emphasizing the importance of managing the risk of diabetic ketoacidosis [15][66] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the potential of LX9211 to become a new treatment option for neuropathic pain, highlighting its independence from the opioid pathway [22][26] - The company anticipates a significant reduction in operating expenses for 2020, with full-year operating expenses expected to be between $225 million and $231 million [48] Other Important Information - The company expects to report results from the Phase 2 studies of LX9211 by the end of next year [41] - Upcoming presentations of data from the SOLOIST and SCORED Phase 3 studies of sotagliflozin are scheduled for November 16 [52] Q&A Session Summary Question: Steps to mitigate placebo effect in trials - Management detailed steps taken to mitigate the placebo effect in both diabetic peripheral neuropathy and post-herpetic neuralgia studies, including a large patient cohort and extended efficacy period [58][60] Question: Reason for not extinguishing all debt - The CFO explained that the remaining debt was part of an agreed-upon exchange, and the current level of debt is deemed optimal for future operations [62] Question: Strategy for U.S. approval of sotagliflozin - Management emphasized the need for clear guidance from the FDA regarding the management of DKA risk and the importance of ongoing dialogue with the agency [66] Question: Concerns about competitors in type 1 diabetes - Management acknowledged the possibility of competitors benefiting from their efforts but expressed confidence in their unique position and data advantage [71] Question: Discovery pipeline and new compounds - Management indicated potential for moving another asset into IND-enabling studies in 2021, while focusing primarily on LX9211 and sotagliflozin [74] Question: Q4 spending and baseline for 2021 - The CFO noted that Q4 R&D spending will be higher than in 2021 due to winding down activities related to sotagliflozin [77] Question: Patient enrollment pace for Phase 2 trials - Management acknowledged the impact of COVID-19 on enrollment but expressed commitment to accelerating patient recruitment [81]

Lexicon Pharmaceuticals, Inc. (NASDAQ:LXRX) Q2 2020 Earnings Conference Call July 30, 2020 8:00 AM ET Company Participants Kimberly Lee - Head, Investor Relations and Corporate Strategy Lonnel Coats - President and Chief Executive Officer Alex Santini - Executive Vice President and Chief Commercial Officer Pablo Lapuerta - Executive Vice President and Chief Medical Officer Praveen Tyle - Executive Vice President, Research and Development Jeff Wade - Executive Vice President, Corporate and Administrative Aff ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2020 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from _____________ to _____________ Commission File Number: 000-30111 Lexicon Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) (State or ...