Core Viewpoint - Mural Oncology plc has entered into a definitive agreement with XOMA Royalty Corporation for the acquisition of Mural's entire issued share capital, which is seen as beneficial for Mural shareholders following a strategic review process [1][52]. Transaction Details - The acquisition will provide Mural shareholders with a base cash price of $2.035 per share, with the potential for an additional cash amount of up to $0.205 per share based on Mural's Closing Net Cash exceeding estimated amounts [2][54]. - The total valuation of Mural's share capital in the acquisition is approximately $36.2 million, excluding any additional payments [4][56]. - The acquisition is expected to close by the end of 2025, subject to shareholder approval and High Court sanction [9][53]. Strategic Review Background - Mural Oncology is focused on developing cytokine-based immunotherapies for cancer treatment [13][63]. - Following unsuccessful clinical trials, Mural decided to explore strategic alternatives to maximize shareholder value, leading to the acquisition proposal from XOMA Royalty [14][64]. - The Mural Board evaluated various options, including liquidation and reverse takeovers, concluding that the acquisition was the best route for shareholder value [71][72]. Board Recommendations - The Mural Board, advised by Lucid Capital Markets, considers the acquisition terms fair and reasonable, recommending that shareholders vote in favor [8][73]. - Mural directors holding approximately 0.42% of shares have committed to vote in favor of the acquisition [7][74].

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from _________________ to _________________ Commission File Number: 001-41837 Mural Oncology plc (Exact Name of Registrant as Specified in its Charter) (State or othe ...

Exhibit 99.1 WALTHAM, Mass. and DUBLIN, Aug. 04, 2025 (GLOBE NEWSWIRE) — Mural Oncology plc (Nasdaq: MURA), today announced its financial results for the second quarter of 2025 and provided a business update. On April 15, 2025, Mural announced that it was discontinuing all clinical development of its lead product candidate, nemvaleukin alfa, and was commencing the exploration of strategic alternatives focused on maximizing shareholder value. The Company is continuing to explore strategic alternatives. Follo ...

WALTHAM, Mass. and DUBLIN, May 19, 2025 (GLOBE NEWSWIRE) -- In accordance with Rule 2.12 of the Irish Takeover Panel Act 1997, the Irish Takeover Rules 2022 (the “Irish Takeover Rules”), Mural Oncology plc (Nasdaq: MURA), a clinical-stage immuno-oncology company, (“Mural”) confirms that, as of the close of business on May 1, 2025, the issued share capital of Mural was 17,268,881 ordinary shares with par value US$0.01 each (the “Ordinary Shares”). In addition, as of the close of business on March 31, 2025, ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 (Exact Name of Registrant as Specified in its Charter) (State or other jurisdiction of incorporation or organization) 10 Earlsfort Terrace Dublin 2, D02 T380, Ireland Not Applicable (Address of principal executive offices) (Zip Code) Ireland 98-1748617 (I.R.S. Employer Identification No.) For the quarterly period ended March 31, ...

Key Information - The disclosure is made by Mural Oncology plc, which is the offeree in relation to its relevant securities [2][5] - The position held date is April 29, 2025, which is the latest practicable date prior to the disclosure [2] - There are no interests or short positions disclosed for Mural Oncology plc [5] Interests and Short Positions - The table indicates that there are no relevant securities owned or controlled, cash-settled derivatives, or stock-settled derivatives by the discloser [5] - Total interests and short positions are reported as NIL [5] Interests of Directors - Caroline Loew holds 43,622 ordinary shares, representing 0.25% of the total issued share capital, with a total of 865,908 underlying stock options and other rights [7] - Other directors have varying numbers of underlying shares, with a total of 967,026 ordinary shares accounted for among them [7] Other Information - There are no indemnity or option arrangements or agreements related to relevant securities that may influence dealings [8] - No supplemental forms are attached to this disclosure [11]

Core Viewpoint - Mural Oncology (MURA) announced the discontinuation of all clinical development of nemvaleukin alfa, leading to a 134% surge in its stock price as investors anticipate potential strategic alternatives to maximize shareholder value [1][3]. Company Decisions - The company will explore various strategic options, including a potential sale, merger, or other transactions, with no set timeline for this process [2]. - Mural Oncology will reduce its workforce by 90% as part of its restructuring efforts [1]. Financial Performance - As of December 31, 2024, Mural Oncology reported approximately $144.4 million in cash, cash equivalents, and marketable securities [4]. Pipeline Setbacks - The decision to halt clinical development follows the failure of the phase II ARTISTRY-6 study for melanoma and disappointing results from the phase III ARTISTRY-7 study for platinum-resistant ovarian cancer (PROC) [4][9]. - The ARTISTRY-6 study did not meet its primary goal, and the ARTISTRY-7 study showed no statistically significant improvement in overall survival compared to chemotherapy [7][9]. Market Reaction - Investors reacted positively to the announcement, likely due to hopes of recovering value lost from previous setbacks, as MURA shares have declined 25.2% year-to-date compared to the industry’s 7.1% decline [3].

Core Viewpoint - Mural Oncology has decided to discontinue all clinical development of nemvaleukin alfa following unsatisfactory results from the ARTISTRY-6 and ARTISTRY-7 trials, and will explore strategic alternatives to maximize shareholder value [1][2][3] Company Developments - Mural Oncology will reduce its workforce by approximately 90% as part of its restructuring efforts [1] - The company had approximately $144.4 million in cash, cash equivalents, and marketable securities as of December 31, 2024 [1] - Mural has engaged Lucid Capital Markets, LLC as its financial advisor to assist in exploring strategic alternatives [1][3] Clinical Trial Results - The ARTISTRY-6 trial did not achieve its primary endpoint in evaluating nemvaleukin as a monotherapy for mucosal melanoma [2] - Preliminary data from ARTISTRY-6 cohort 3, which assessed less-frequent intravenous dosing in cutaneous melanoma patients, also did not show sufficient activity to warrant continuation [2] - Interim overall survival results from the ARTISTRY-7 trial in platinum-resistant ovarian cancer contributed to the decision to halt development of nemvaleukin [2] Strategic Alternatives - Mural is considering various strategic alternatives, including potential offers for acquisition, mergers, or other business combinations [3] - The company is currently in an "offer period" as defined by the Irish Takeover Rules, which may affect the exploration of strategic alternatives [5][6] Regulatory Considerations - Mural is subject to the Irish Takeover Panel Act and must comply with specific disclosure requirements during the strategic evaluation process [5][10]

Core Insights - Mural Oncology has decided not to progress the ARTISTRY-7 phase 3 trial of nemvaleukin alfa in combination with KEYTRUDA® for platinum-resistant ovarian cancer due to lack of statistically significant improvement in overall survival compared to chemotherapy [1][6] - The median overall survival was reported as 10.1 months for the combination therapy versus 9.8 months for chemotherapy, with a hazard ratio of 0.98 indicating no significant benefit [1] - The company remains focused on its upcoming topline results from the ARTISTRY-6 trial in mucosal melanoma, expected in Q2 2025 [2][4] Company Overview - Mural Oncology is a clinical-stage immuno-oncology company developing cytokine-based immunotherapies, with a focus on leveraging its protein engineering platform [9] - The lead candidate, nemvaleukin, is designed to enhance antitumor effects while minimizing toxicities associated with traditional IL-2 therapies [7] - The company has treated over 800 patients across its broader clinical program, demonstrating a favorable safety profile for nemvaleukin [3][9] Clinical Trials - The ARTISTRY-7 trial involved 456 patients and was designed to compare nemvaleukin with pembrolizumab against investigator's choice chemotherapy, focusing on overall survival as the primary endpoint [6] - The ARTISTRY-6 trial is currently evaluating nemvaleukin in mucosal melanoma, with topline data readouts expected in Q2 2025, alongside preliminary data for cutaneous melanoma in the same timeframe [4][8]

Company Status and Growth - The company qualifies as an "emerging growth company" and may remain so until December 31, 2028, unless certain financial thresholds are exceeded, such as a market value of $700 million or annual gross revenues of $1.235 billion [555]. - The company is permitted to provide only two years of audited financial statements and is exempt from auditor attestation requirements for internal control over financial reporting while it remains an emerging growth company [558]. - The company may continue to qualify as a smaller reporting company, allowing it to take advantage of certain disclosure exemptions [556]. Financial Outlook and Shareholder Returns - The company anticipates significant additional capital will be needed in the future, which may lead to substantial dilution for existing shareholders if equity securities are issued [564]. - The company does not intend to pay dividends in the foreseeable future, with returns to shareholders likely limited to share appreciation [569]. - The company currently does not intend to pay dividends, as it lacks distributable reserves under Irish law [592]. Compliance and Regulatory Challenges - The company is subject to increased costs and demands on management resources due to compliance with public company regulations, including the Sarbanes-Oxley Act [575]. - The company is required to furnish a report on internal control over financial reporting, which is costly and challenging, and may not be completed within the prescribed timeframe [577]. Market Volatility and Share Price Influences - The company may face volatility in share price due to various factors, including adverse clinical trial results and regulatory decisions [561]. - The company’s share price may be influenced by the actions of activist shareholders, which could lead to periods of volatility [568]. - The company’s financial results may not be comparable to other public companies due to its election to adopt new accounting standards at the same time as private companies [558]. Strategic Transactions and Financial Impact - The company may engage in strategic transactions such as acquisitions, which could impact liquidity and increase expenses [580]. - Future acquisitions may require additional financing, potentially affecting financial condition and results of operations [580]. - The company is restricted from entering certain transactions for a four-year period due to a tax matters agreement [581]. Legal and Tax Considerations - Irish law may afford less protection to holders of the company's securities compared to U.S. laws [582]. - The company may face challenges in enforcing U.S. court judgments in Ireland due to the lack of a reciprocal treaty [587]. - Any takeover offer will be subject to the Irish Takeover Rules, which may restrict the company's actions during the offer period [588]. - Transfers of ordinary shares may be subject to a 1% Irish stamp duty if not held through the Depository Trust Company [589]. - Future financing arrangements may impose restrictions that could adversely affect the company's ability to obtain financing [591]. - Changes in tax laws could adversely affect the company and its shareholders, with potential retroactive applications impacting financial conditions [601]. - Non-U.S. governments may enact tax laws in response to U.S. tax rule changes, potentially affecting the company's global financial position [602]. Cash Management and Financial Strategy - The company has broad discretion in the use of cash, cash equivalents, and marketable securities, which may not enhance operating results or shareholder value [603]. - Unfavorable global economic conditions could adversely affect the company's business and financial results [598].