NUCANA PLC UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS | | | For the Three Months Ended | | | --- | --- | --- | --- | | | | March 31, | | | | Notes | 2022 | 2021 | | | | (in thousands, except per share data) | | | | | £ | £ | | Research and development expenses | | (9,446) | (8,706) | | Administrative expenses | | (2,152) | (2,104) | | Net foreign exchange gains (losses) | | 1,131 | (677) | | Operating loss | | (10,467) | (11,487) | | Finance income | | 31 | 24 | | Loss before tax | | (10,436) ...

As filed with the Securities and Exchange Commission on April 27, 2022 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☐ SHELL COMPANY REPORT PURSUANT ...

Exhibit 99.1 NuCana Reports Fourth Quarter and Year Ended 2021 Financial Results and Provides Business Update Optimizes Development Strategy with Study Initiations and Data Announcements Expected throughout 2022 Announces Plan to Initiate Randomized Phase 2 Study for NUC-3373 in Colorectal Cancer Extends Anticipated Cash Runway into 2025 Edinburgh, United Kingdom, April 27, 2022 (GLOBE NEWSWIRE) – NuCana plc (NASDAQ: NCNA) announced financial results for the fourth quarter and year ended December 31, 2021 a ...

| --- | --- | |---------------------------------|--------------------------------------| | | | | | | | | | | | | | | Corporate Presentation | | | February 2021 Corporate Presentation | | www.nucana.com www.nucana.com | February 2022 | Disclaimer Forward-Looking Statements This presentation contains "forward-looking" statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are based on the beliefs and assumptions and on information currently available to management of NuCana ...

| --- | --- | |---------------------------------|-------------------------------------------------------------| | | | | | | | | | | | | | | | | | | | | | | | Corporate Presentation February 2021 Corporate Presentation | | www.nucana.com www.nucana.com | September 2021 | Disclaimer Forward-Looking Statements This presentation contains "forward-looking" statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are based on the beliefs and assumptions and on information current ...

| --- | --- | |---------------------------------|-------------------------------------------------------------| | | | | | | | | | | | | | | | | | | | | | | | Corporate Presentation February 2021 Corporate Presentation | | | June 2021 | | www.nucana.com www.nucana.com | | Disclaimer Forward-Looking Statements This presentation contains "forward-looking" statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are based on the beliefs and assumptions and on information curren ...

| --- | --- | |----------------|-------------------------------------------------------------| | | | | | | | | | | | | | | | | | | | | | | | Corporate Presentation February 2021 Corporate Presentation | | www.nucana.com | March 2021 | | www.nucana.com | | Disclaimer Forward-Looking Statements This presentation contains "forward-looking" statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are based on the beliefs and assumptions and on information currently available to ...

As filed with the Securities and Exchange Commission on March 4, 2021 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☐ SHELL COMPANY REPORT PURSUANT ...

| --- | --- | --- | --- | --- | --- | |--------------------------------------|-------|-------|-------|-------|----------------| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Corporate Presentation December 2020 | | | | | www.nucana.com | Disclaimer Forward-Looking Statements This presentation contains "forward-looking" statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are based on the beliefs and assumptions and on information currently avai ...

| --- | --- | --- | --- | --- | --- | |---------------------------------------|-------|-------|-------|-------|----------------| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Corporate Presentation September 2020 | | | | | | | | | | | | www.nucana.com | Disclaimer Forward-Looking Statements This presentation contains "forward-looking" statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are based on the beliefs and assumptions and on informatio ...