UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Fiscal Year Ended: December 31, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from __________________ to __________________ Commission file number: 001-37969 ENDRA Life Sciences Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 2 ...

Exhibit 99.1 ENDRA Life Sciences Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Business Update ANN ARBOR, Mich. (March 31, 2026) – ENDRA Life Sciences Inc. (NASDAQ: NDRA) ("ENDRA" or the "Company"), a pioneer in thermoacoustic biomarker imaging for early detection and monitoring of steatotic liver disease (SLD), today reported financial results for the quarter and year ended December 31, 2025, and provided a business update. Business Update ● Initiated Evaluation of Strategic Alte ...

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Key Takeaways NDRA reported strong repeatability and reproducibility data for TAEUS Liver in a clinical MASLD study.TAEUS Liver achieved 0.89 ICC and 3.3% SEM, signaling good-to-excellent measurement reliability.NDRA aims to offer MRI-comparable liver fat assessment via accessible point-of-care ultrasound.ENDRA Life Sciences (NDRA) recently announced positive findings from a clinical study assessing the measurement consistency of its TAEUS Liver device. The evaluation demonstrated strong intra-operator repe ...

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Revenue and Financial Performance - No revenue was generated from the TAEUS technology during the three months ended September 30, 2025, and 2024[110]. - The net loss for the three months ended September 30, 2025, was $1,595,959, an improvement from a net loss of $2,354,090 for the same period in 2024[130]. - Net loss narrowed to $3,858,201 for the nine months ended September 30, 2025, compared to a net loss of $7,358,943 for the same period in 2024[136]. - As of September 30, 2025, the company had an accumulated deficit of $107,296,300 and cash of $794,036[137]. - The company used $3,570,847 of cash in operating activities during the nine months ended September 30, 2025, primarily due to the net loss[140]. Expenses - Research and development expenses decreased by 46% to $432,113 for the three months ended September 30, 2025, compared to $794,444 for the same period in 2024[126]. - Sales and marketing expenses also decreased by 46% to $45,285 for the three months ended September 30, 2025, down from $83,157 in the prior year[127]. - General and administrative expenses increased by 41% to $893,305 for the three months ended September 30, 2025, compared to $631,413 for the same period in 2024[128]. - Research and development expenses decreased by 47% to $1,341,859 for the nine months ended September 30, 2025, compared to $2,552,336 for the same period in 2024[132]. - Sales and marketing expenses decreased by 62% to $183,110 for the nine months ended September 30, 2025, compared to $484,769 for the same period in 2024[133]. - General and administrative expenses decreased by 25% to $2,616,106 for the nine months ended September 30, 2025, compared to $3,483,303 for the same period in 2024[134]. - Other income increased by 134% to $282,874 for the nine months ended September 30, 2025, compared to an expense of $838,535 for the same period in 2024[135]. Financing and Capital Activities - The company closed a private placement on October 15, 2025, raising approximately $4.9 million, primarily to establish its Digital Asset Treasury strategy[109]. - Financing activities provided $1,152,684 in proceeds from issuances of common stock for the nine months ended September 30, 2025[143]. - The company is considering potential financing options, including sales of common stock, to support its commercialization plans and DAT strategy[138]. Future Plans and Strategies - Research and development expenses are expected to continue as the company pursues FDA approval for the NAFLD TAEUS system[113]. - The company plans to incur up to $750,000 of offering proceeds on a pilot validation study for the TAEUS liver device[109]. - The company anticipates continued costs associated with being a public company, including compliance with Nasdaq and SEC requirements[115]. - The company plans to advance the engineering design and development of its TAEUS technology and complete regulatory filings for marketing approval of its NAFLD TAEUS application[146]. - The company purchased 78,863.1 HYPE tokens valued at approximately $3,000,000 as part of its DAT strategy[109].

Group 1 - ENDRA Life Sciences has initiated staking of its holdings in HYPE, the native token of the Hyperliquid ecosystem, to enhance the utility and returns of its HYPE treasury [1] - The staking initiative is guided by ARCA Investment Management and secured by Anchorage Digital, indicating a strategic partnership with industry leaders [1] - CEO Alexander Tokman emphasized that the HYPE staking program represents a significant evolution in the company's digital asset strategy, focusing on productive capital deployment within a compliant framework [1]

Group 1 - U.S. stock futures are lower, with Dow futures falling more than 350 points [1] - Orion SA expects third-quarter adjusted EBITDA to be around $55 million and full-year adjusted EBITDA in the range of $220-$235 million, leading to an 18.6% drop in shares to $5.56 in pre-market trading [1] Group 2 - ENDRA Life Sciences Inc shares fell 19.4% to $6.54 after a previous 25% increase due to $4.9 million in funding commitments [4] - Canaan Inc shares tumbled 11.8% to $1.34 after a 39% jump, despite a maintained Buy rating and $4 price target from Rosenblatt analyst [4] - DBV Technologies SA shares fell 11.8% to $14.48 after gaining around 10% previously [4] - Nanobiotix SA shares tumbled 10.2% to $27.23 after a previous increase of over 28% [4] - Draganfly Inc shares dipped 9.4% to $12.47 after filing for a mixed shelf of up to $200 million [4] - Bitdeer Technologies Group shares fell 9% to $18.61 after a 15% gain [4] - Diginex Ltd shares fell 9% to $23.40 [4] - HIVE Digital Technologies shares dipped 8.1% to $6.21, despite a maintained Buy rating and $10 price target [4] - Oatly Group AB shares fell 7.8% to $13.29 after a 5% gain [4] - Bit Digital Inc shares declined 7.7% to $3.69 after a previous gain of over 6% [4] - Upexi Inc shares fell 7.7% to $5.98 [4] - Sharplink Gaming Inc shares declined 7.1% to $14.98 after adding 5% previously [4] - Nio Inc shares fell 5% to $6.82, influenced by new port fees affecting US-listed Chinese stocks [4] - Alibaba Group Holding Ltd shares declined 4% to $160.20, also impacted by new port fees [4]