Core Insights - Palisade Bio is advancing its precision medicine approach for ulcerative colitis (UC) through a collaboration with Strand Life Sciences, focusing on PDE4-related biomarkers [1][2][9] - The company aims to refine patient selection strategies to optimize clinical outcomes for UC patients by integrating clinical biomarkers, disease activity measures, and transcriptomics data [3][4][10] Collaboration and Research Progress - The collaboration with Strand Life Sciences has led to the identification of promising PDE4-related biomarkers associated with UC pathology, which are crucial for targeted therapeutic interventions [1][9] - Ongoing research is dedicated to developing innovative selection strategies for biomarkers that overlap with UC pathophysiology, enhancing the precision medicine approach [3][9] Future Outlook - Palisade Bio's CEO, JD Finley, expressed the company's ambition to lead in developing precision medicine solutions for inflammatory and fibrotic diseases, aiming to create value for investors while helping patients [5] - Dr. Mitch Jones, CMO at Palisade Bio, reaffirmed the commitment to advancing precision medicine solutions for UC and other inflammatory indications through collaborative efforts [10]

– Collaboration advancing Palisade Bio's precision medicine approach through access to cutting-edge expertise and tools in bioinformatics Carlsbad, CA, June 21, 2024 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (Nasdaq: PALI) ("Palisade", "Palisade Bio" or the "Company"), a biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, today provided an update on key areas of progress for its previously announced strategic ...

Palisade Bio (PALI) Conference June 17, 2024 08:30 AM ET Speaker0 Okay. We are ready to get started. Good afternoon, and welcome back to the Virtual Investor twenty twenty four Pitch Conference. My name is Janine Thomas. I am CEO of JTCIR, and I will be the moderator for today's event. So for this event, each presenting company will provide a five to seven minute elevator pitch followed by a q and a session. We had a great morning session. And to kick off our afternoon session, I am pleased to be joined by ...

A downtrend has been apparent in Palisade Bio, Inc. (PALI) lately. While the stock has lost 29.7% over the past four weeks, it could witness a trend reversal as a hammer chart pattern was formed in its last trading session. This could mean that the bulls have been able to counteract the bears to help the stock find support. The formation of a hammer pattern is considered a technical indication of nearing a bottom with likely subsiding of selling pressure. But this is not the only factor that makes a bullish ...

Carlsbad, CA, June 11, 2024 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (Nasdaq: PALI) ("Palisade" or the "Company"), biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, today announced that the Canadian Intellectual Property Office (CIPO) has issued a Notice of Allowance for patent application number 3,174,137 titled, "Gut Microbiota Bioactivated PDE4 Inhibitor Precursors." This patent covers the composition o ...

As part of the event, J.D. Finley, Chief Executive Officer of Palisade Bio, will provide an "elevator pitch" and outline the Company's upcoming milestones. Additionally, investors and interested parties will have the opportunity to submit questions live during the event. Participating companies will answer as many questions as possible in the time allowed. Palisade Bio is a biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and ...

As part of the event, J.D. Finley, Chief Executive Officer of Palisade Bio, will provide an "elevator pitch" and outline the Company's upcoming milestones. Additionally, investors and interested parties will have the opportunity to submit questions live during the event. Participating companies will answer as many questions as possible in the time allowed. About Palisade Bio Carlsbad, CA, June 10, 2024 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (Nasdaq: PALI) ("Palisade" or the "Company"), biopharmaceutical com ...

Core Insights - PALI-2108 is a promising orally delivered, colon-specific PDE4 inhibitor prodrug for Ulcerative Colitis (UC) treatment, demonstrating safety, efficacy, and tolerability in preclinical studies [1][3][8] - The company plans to initiate Phase 1 human clinical trials for PALI-2108 by the end of 2024 [1] Group 1: Preclinical Data and Efficacy - Preclinical studies showed PALI-2108 exhibited a dose-dependent efficacy response in two DSS colitis mouse models, achieving efficacy comparable to intolerable doses of apremilast for human use [1][8] - Significant advancements were made in assessing on-target PDE4 binding within colon tissue, utilizing a cellular thermal shift assay (CETSA) [3] - In a DSS colitis mouse model, PALI-2108 significantly prevented colon length reduction and improved various disease activity scores in a dose-dependent manner [8] Group 2: Safety and Therapeutic Window - PALI-2108 demonstrated no systemic toxicity in dogs, indicating a large therapeutic window due to its local activation [8] - A single oral dose of PALI-2108 prevented emesis observed with lower doses of the active PDE4 moiety, showcasing an enhanced therapeutic profile [5][8] Group 3: Company Overview - Palisade Bio is focused on developing novel therapeutics for autoimmune, inflammatory, and fibrotic diseases, aiming to transform treatment landscapes with targeted approaches [9]

Core Insights - PALI-2108 is a promising orally delivered, colon-specific PDE4 inhibitor prodrug for Ulcerative Colitis (UC) treatment, demonstrating safety, efficacy, and tolerability in preclinical studies [1][3][8] - The company plans to initiate Phase 1 human clinical trials for PALI-2108 by the end of 2024 [1] Preclinical Data - PALI-2108 showed a dose-dependent efficacy response in two DSS colitis mouse models, achieving results comparable to intolerable doses of apremilast for human use [1][8] - The study utilized an acute colitis model in mice, with treatments of PALI-2108 at doses of 20, 40, and 80 mg/kg administered twice daily, alongside cyclosporin A and apremilast [4][8] - Significant improvements were observed in body weight score, stool consistency score, fecal blood score, and overall disease activity index (DAI) score [8] Safety and Tolerability - PALI-2108 demonstrated no systemic toxicity in dogs, indicating a large therapeutic window due to its local activation [5][8] - The prodrug effectively prevented emesis that was observed with lower doses of the active PDE4 moiety, showcasing enhanced therapeutic potential [5] Company Overview - Palisade Bio is focused on developing novel therapeutics for autoimmune, inflammatory, and fibrotic diseases, aiming to transform treatment landscapes with targeted approaches [9]

Carlsbad, CA, May 14, 2024 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (NASDAQ:PALI) ("Palisade", "Palisade Bio" or the "Company"), a biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, today reported its financial results for the first quarter 2024 and provided a business update. Recent Highlights "Our team remains focused on advancing PALI-2108 towards our first-in-human study, which is on track to start late ...