Core Insights - PDS Biotechnology Corporation announced promising clinical results for its immunotherapy, Versamune® HPV, in combination with PDS01ADC and a PD-L1 immune checkpoint inhibitor for treating recurrent/metastatic HPV-associated cancers [1][2][4] Group 1: Clinical Results - The median overall survival (mOS) for immune checkpoint inhibitor (ICI) naïve patients was reported at 42.4 months, significantly higher than the historical range of 7-12 months [1][5] - In HPV16-positive ICI resistant patients, the mOS was 17 months, compared to the historical result of 3-4 months [1][9] - The objective response rate (ORR) for HPV16-positive ICI naïve patients was 75%, while the historical ORR for this group was 11-24% [1][5] Group 2: Trial Details - The clinical trial was a single-center, non-randomized study led by the National Cancer Institute (NCI), involving 50 patients with recurrent/metastatic HPV-positive cancers [2][6] - Among the enrolled patients, 52% were men, with a median age of 56 years, and 37 patients were HPV16-positive [2][6] - The trial evaluated Versamune® HPV at a fixed dose, PDS01ADC at both high (16.8 ug/kg) and low (8.0 ug/kg) doses, and bintrafusp alfa (BA) at high and low doses [3] Group 3: Future Directions - The company plans to initiate the VERSATILE-003 Phase 3 trial of Versamune® HPV combined with pembrolizumab for recurrent/metastatic HPV16-positive head and neck squamous cell carcinoma [2][7] - The results support the continued investigation of both Versamune® HPV and PDS01ADC in ongoing and future clinical trials [6][7]

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Core Insights - PDS Biotechnology Corporation is a late-stage immunotherapy company focused on enhancing the immune system's ability to target and eliminate cancers [4] - The company will participate in a fireside chat at the B. Riley Securities Precision Oncology & Radiopharma Conference on February 28, 2025 [1][2] Company Overview - PDS Biotechnology is developing its lead investigational targeted immunotherapy, Versamune® HPV, in combination with a standard immune checkpoint inhibitor and a triple combination including PDS01ADC, an IL-12 fused antibody drug conjugate [4] - The company plans to initiate a pivotal clinical trial for advanced HPV16-positive head and neck squamous cell cancers [4] Event Details - The fireside chat will take place from 11:30 AM to 12:00 PM ET at the Lotte New York Palace Hotel, New York, NY [2] - PDS Biotech leadership will also conduct one-on-one meetings during the conference [2] Additional Information - An archived transcript of the fireside chat will be available on the company's Investor Relations section one week after the event [3]

Financial Data and Key Metrics Changes - Precision Drilling reported annual revenue of CAD 1.9 billion, essentially flat year-over-year, with adjusted EBITDA of CAD 521 million, a 15% decrease year-over-year [10] - Funds from operations were CAD 463 million, a 13% decrease, while cash from operations remained similar to the prior year at CAD 482 million [11] - The company achieved a debt reduction of CAD 176 million and completed CAD 75 million in share repurchases, representing 4% of outstanding shares [11] Business Line Data and Key Metrics Changes - In the U.S. drilling segment, average rig activity was 34 rigs in Q4, a decrease of 1 rig from Q3, with daily operating margins of USD 9,165, below guidance [13] - Canadian drilling activity averaged 55 rigs, an increase of 1 rig from Q4 2024, with daily operating margins of CAD 14,559, an increase of approximately CAD 2,131 from Q3 2024 [14] - Internationally, average drilling activity was 8 rigs with average day rates of USD 49,636, consistent with the prior year [16] Market Data and Key Metrics Changes - The Canadian market outlook remains positive, with indications of increased activity during the breakup period, expected to exceed last year's record levels [41] - The U.S. land market has been challenging, with gas-directed activity declining and oil-directed activity impacted by various factors [32][36] - Internationally, oil activity is expected to remain flat for 2025, with no suspension requests in Saudi Arabia and firm operations in Kuwait [46] Company Strategy and Development Direction - The company’s 2025 strategic priorities focus on maximizing free cash flow, reducing debt, and enhancing shareholder returns through share repurchases [4] - Precision aims to grow revenue in existing service lines and strengthen its competitive position through operational excellence and market penetration of its products [9] - The company is transitioning its strategy to allocate more cash towards share buybacks while considering growth-focused investments [31] Management's Comments on Operating Environment and Future Outlook - Management expressed cautious optimism regarding gas opportunities in the U.S. while acknowledging challenges in the oil market due to operator capital discipline and commodity price volatility [34][36] - The Canadian market is expected to see increased demand, particularly with LNG Canada starting up, which should enhance rig demand [42] - Management remains focused on maintaining operational efficiency and leveraging technology to improve market positioning [38][85] Other Important Information - Capital expenditures for the quarter were CAD 59 million, with a total of CAD 217 million for the year, slightly above guidance due to equipment delivery timing [18] - The company has a capital plan of CAD 225 million for 2025, with a focus on sustaining infrastructure and upgrades [18] - As of December 31, long-term debt was CAD 748 million, with a net debt-to-EBITDA ratio of approximately 1.4x [20] Q&A Session Summary Question: Can you speak to contract duration for idle but contracted rigs in the U.S.? - Management noted that there has been significant churn in the U.S. market, with many contracts being short-term, indicating downside risk for the first couple of quarters [52][54] Question: What assumptions support expected activity growth in the second half of the year? - Management highlighted conversations with customers indicating a comfort level for gas prices in the high 3s to mid-4s range, suggesting potential rig count stability and opportunities in Q2 and Q3 [56][58] Question: How do you see Canadian activity levels progressing throughout the year? - Management indicated that Q1 margins are impacted by rig reactivations and a shift in rig mix, but they expect pricing traction and improved margins as the year progresses [60][66] Question: What is the impact of tariffs on your operations? - Management expressed that the reduced tariff levels have less impact compared to larger macroeconomic factors, and they have strategies in place to manage potential tariff-related costs [71][73] Question: Is there any indication of private equity returning to the E&P space? - Management confirmed that there is capital returning to the E&P space, which is a positive sign for future activity levels [78] Question: How do you view the tuck-in acquisition opportunities in the current market? - Management acknowledged that while the market for consolidation exists, valuation remains a challenge, and they are focused on pursuing opportunities at the right price [92][94]

Core Viewpoint - Precision Drilling reported quarterly earnings of $0.76 per share, significantly missing the Zacks Consensus Estimate of $1.40 per share, and down from $3.45 per share a year ago, indicating a -45.71% earnings surprise [1][2] Financial Performance - The company posted revenues of $334.62 million for the quarter ended December 2024, which was 1.70% below the Zacks Consensus Estimate and down from $372.34 million year-over-year [2] - Over the last four quarters, Precision Drilling has surpassed consensus EPS estimates two times and topped revenue estimates only once [2] Stock Performance - Precision Drilling shares have declined approximately 6.7% since the beginning of the year, contrasting with the S&P 500's gain of 3.2% [3] - The stock currently holds a Zacks Rank 5 (Strong Sell), indicating expectations of underperformance in the near future [6] Earnings Outlook - The current consensus EPS estimate for the upcoming quarter is $1.91 on revenues of $367.84 million, and for the current fiscal year, it is $8.46 on revenues of $1.37 billion [7] - The trend of estimate revisions for Precision Drilling has been unfavorable leading up to the earnings release [6] Industry Context - The Oil and Gas - Drilling industry is currently ranked in the bottom 26% of over 250 Zacks industries, suggesting that the outlook for the industry could materially impact the stock's performance [8] - Empirical research indicates a strong correlation between near-term stock movements and trends in earnings estimate revisions, which could be a useful measure for investors [5]

Core Viewpoint - Precision Drilling Corporation is set to release its 2024 fourth quarter and year-end results on February 12, 2025, followed by a conference call on February 13, 2025 [1] Company Overview - Precision Drilling is a leading provider of safe and environmentally responsible services to the energy industry, offering access to a fleet of Super Series drilling rigs [5] - The company has developed an industry-leading digital technology portfolio known as Alpha™, which utilizes advanced automation software and analytics for efficient results [5] - Precision's services are complemented by the EverGreen™ suite of environmental solutions, aimed at reducing the environmental impact of operations [5] - The company also provides well service rigs, camps, and rental equipment, supported by technical services and experienced personnel [5] - Precision is headquartered in Calgary, Alberta, Canada, and is listed on the Toronto Stock Exchange under the symbol "PD" and on the New York Stock Exchange under "PDS" [6]

PRINCETON, N.J., Dec. 03, 2024 (GLOBE NEWSWIRE) -- PDS Biotechnology Corporation (Nasdaq: PDSB) (“PDS Biotech” or the “Company”), a late-stage immunotherapy company focused on transforming how the immune system targets and kills cancers and the development of infectious disease vaccines, today announced a Key Opinion Leader (“KOL”) event to discuss the pathology and growing prevalence of HPV16-positive head and neck squamous cell carcinoma (“HNSCC") as well as the Company’s upcoming VERSATILE-003 Phase 3 cl ...

Austin, Nov. 19, 2024 (GLOBE NEWSWIRE) -- The Drill Bit Market Size was valued at USD 2.28 billion in 2023 and is anticipated to reach USD 4.12 billion by 2032, growing at a compound annual growth rate (CAGR) of 6.81% from 2024 to 2032. Book Your Sample PDF for Drill Bit Market Report @ https://www.snsinsider.com/sample-request/2410 Drill Bit Market Report Scope: Report AttributesDetailsMarket Size in 2023USD 2.28 billionMarket Size by 2032USD 4.12 billionCAGRCAGR of 6% by 2024-2032Base Year2023Forecast Pe ...

Analyst’s Disclosure: I/we have a beneficial long position in the shares of ESI:CA either through stock ownership, options, or other derivatives. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article. My articles, blog posts, and comments on this platform do not constitute investment recommendations, but rather express my personal opinions ...

PRINCETON, N.J., Nov. 06, 2024 (GLOBE NEWSWIRE) -- PDS Biotechnology Corporation (Nasdaq: PDSB) (“PDS Biotech” or the “Company”), a late-stage immunotherapy company focused on transforming how the immune system targets and kills cancers and the development of infectious disease vaccines, today announced that the Company will host a conference call to report financial results for the quarter ended September 30, 2024, and provide a clinical program update on Thursday, November 14, 2024, at 8:30 a.m. Eastern T ...