UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36544 Sage Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 27-4486580 (State or Other Jurisdictio ...

Sage Therapeutics, Inc. (NASDAQ:SAGE) Q3 2022 Earnings Conference Call November 8, 2022 8:00 AM ET Company Participants Helen Rubinstein - Director, IR Barry Greene - Chief Executive Officer Kimi Iguchi - Chief Financial Officer Jim Doherty - Chief Development Officer Chris Benecchi - Chief Business Officer Jeff Jonas - Chief Innovation Officer Conference Call Participants Yasmeen Rahimi - Piper Sandler Ritu Baral - Cowen Salveen Richter - Goldman Sachs Paul Matteis - Stifel Laura Chico - Wedbush Jay Olson ...

Sage Therapeutics, Inc. (NASDAQ:SAGE) Q2 2022 Earnings Conference Call August 2, 2022 8:00 AM ET Company Participants Helen Rubinstein - IR Barry Greene - CEO Albert Robichaud - Chief Scientific Officer Chris Benecchi - Chief Business Officer Kimi Iguchi - CFO Conference Call Participants Ritu Baral - Cowen Paul Matteis - Stifel Ami Fadia - Needham Jay Olson - Oppenheimer Swapnil Malekar - Piper Sandler Yatin Suneja - Guggenheim Marc Goodman - SVB Leerink Gospel Enyindah-Asonye - Morgan Stanley Gary Nachman ...

Sage Therapeutics, Inc. (NASDAQ:SAGE) Q1 2022 Earnings Conference Call May 3, 2022 8:00 AM ET Company Participants Helen Rubinstein - Investor Relations Barry Greene - Chief Executive Officer Jim Doherty - Chief Development Officer Kimi Iguchi - Chief Financial Officer Chris Benecchi - Chief Commercial Officer Conference Call Participants Laura Chico - Wedbush Tiffany Sun - JPMorgan Ritu Baral - Cowen Yatin Suneja - Guggenheim Evan Hua - BMO Capital Markets Vamil Divan - Mizuho Neena Bitritto-Garg - Citi S ...

Investor Presentation May 2022 Safe Harbor Statement • The slides presented today and the accompanying oral presentations contain forward-looking statements, which may be identified by the use of words such as "may," "might," "will," "should," "can,","expect," "plan," "anticipate," "believe," "estimate," "project," "intend," "future," "opportunity", "goal", "mission", "potential," "target", or "continue," and other similar expressions. • Forward-looking statements in this presentation include statements reg ...

SAGE-718 Ongoing Study Designs March 2022 DIMENSION Study - SAGE-718 Placebo-controlled study in patients with early Huntington's disease Status Enrolling Objectives • To evaluate the effect of SAGE-718 on cognitive performance in participants with HD • To evaluate the effect of SAGE-718 on daily function in participants with HD Indication Huntington's Disease Cognitive Impairment Primary Endpoint • Change from baseline in Composite score of the Huntington's Disease Cognitive Assessment Battery (HD-CAB) Pha ...

Investor Presentation February 2022 Safe Harbor Statement • The slides presented today and the accompanying oral presentations contain forward-looking statements, which may be identified by the use of words such as "may," "might," "will," "should," "can,","expect," "plan," "anticipate," "believe," "estimate," "project," "intend," "future," "opportunity", "goal", "mission", "potential," "target", or "continue," and other similar expressions. • Forward-looking statements in this presentation include statement ...

Sage Therapeutics, Inc. (NASDAQ:SAGE) Q4 2021 Earnings Conference Call February 24, 2022 8:00 AM ET Company Participants Helen Rubinstein - Director, IR Barry Greene - CEO Jim Doherty - CDO Kimi Iguchi - CFO Chris Benecchi - CCO Conference Call Participants Andrea Tan - Goldman Sachs Tiffany Sun - JPMorgan Yasmeen Rahimi - Piper Sandler Laura Chico - Wedbush Securities Ami Fadia - Needham & Company Paul Matteis - Stifel Tazeen Ahmad - Bank of America Yatin Suneja - Guggenheim Douglas Tsao - H.C. Wainwright ...

J.P. Morgan Healthcare Conference January 2022 Safe Harbor Statement • The slides presented today and the accompanying oral presentations contain forward-looking statements, which may be identified by the use of words such as "may," "might," "will," "should," "can,","expect," "plan," "anticipate," "believe," "estimate," "project," "intend," "future," "opportunity", "goal", "mission", "potential," "target", or "continue," and other similar expressions. • Forward-looking statements in this presentation includ ...

Investor Presentation November 2021 Safe Harbor Statement • The slides presented today and the accompanying oral presentations contain forward-looking statements, which may be identified by the use of words such as "may," "might," "will," "should," "can,","expect," "plan," "anticipate," "believe," "estimate," "project," "intend," "future," "opportunity", "goal", "mission", "potential," "target", or "continue," and other similar expressions. • Forward-looking statements in this presentation include statement ...