Gaithersburg, Maryland--(Newsfile Corp. - March 26, 2026) - Shuttle Pharmaceuticals Holdings, Inc. (NASDAQ: SHPH) ("Shuttle Pharma" or the "Company"), today announced a major advancement to its molecule.ai platform, significantly expanding its capabilities in therapeutic discovery and positioning the Company at the forefront of AI-driven drug development.The latest release introduces new models that enable users to more effectively evaluate, prioritize, and advance therapeutic candidates. By integrating en ...

Core Viewpoint - E.F. Hutton & Co. acted as the exclusive placement agent for Shuttle Pharmaceuticals' $3.5 million public offering, aimed at supporting the company's AI-driven platform for molecular discovery and drug development [1][2]. Group 1: Offering Details - Shuttle Pharmaceuticals entered into a securities purchase agreement for the issuance of 2,238,800 shares of common stock and pre-funded warrants to purchase 4,761,200 shares, resulting in gross proceeds of approximately $3.5 million before fees and expenses [2]. - The offering closed on March 10, 2026, with Shuttle Pharmaceuticals planning to allocate up to $1.5 million of the net proceeds for marketing efforts, while the remainder will be used for working capital and general corporate purposes [3]. Group 2: Company and Executive Commentary - Joseph T. Rallo, CEO of E.F. Hutton & Co., expressed satisfaction in supporting Shuttle Pharmaceuticals, highlighting the transaction's alignment with the company's operational priorities and development objectives [4]. - The securities were offered under a registration statement filed with the SEC on February 11, 2026, which became effective on February 17, 2026, and the offering was conducted via a prospectus that is part of this registration statement [4]. Group 3: Company Background - E.F. Hutton & Co. is an investment bank and broker-dealer based in Manhattan, providing a range of advisory and financing solutions to various clients, including corporates and public-private partnerships [6]. - The firm offers comprehensive investment banking services, including capital markets, PIPEs, private placements, M&A advisory, and strategic financing, with a global presence across multiple regions [6].

Core Viewpoint - Shuttle Pharmaceuticals Holdings, Inc. has announced a public offering of common stock and pre-funded warrants, aiming to raise approximately $3,500,000 for various corporate purposes [1][2]. Group 1: Offering Details - The company will issue 2,238,800 shares of common stock and pre-funded warrants to purchase 4,761,200 shares of common stock [1]. - The offering is expected to close on or about March 9, 2026, pending customary closing conditions [1]. Group 2: Use of Proceeds - Up to $1.5 million of the net proceeds will be allocated for future marketing efforts [2]. - The remaining funds will be used for working capital and general corporate purposes [2]. Group 3: Company Overview - Shuttle Pharmaceuticals owns Molecule.ai, an AI-driven platform for molecular discovery and early-stage drug development [4]. - The platform integrates modern AI techniques with structured scientific workflows to enhance the efficiency of chemical exploration and decision-making in drug development [4].

As filed with the Securities and Exchange Commission on February 11, 2026 Registration No. 333-293363 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 To FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SHUTTLE PHARMACEUTICALS HOLDINGS, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Delaware 2834 82-5089826 (I.R.S. Employer Identification No.) 401 Pr ...

FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 As filed with the Securities and Exchange Commission on February 10, 2026 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SHUTTLE PHARMACEUTICALS HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 2834 82-5089826 (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identification No.) 401 ...

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Core Insights - Shuttle Pharmaceuticals Holdings, Inc. supports Utah's initiative to allow AI systems to authorize prescription refills without direct physician involvement, marking a significant regulatory advancement in healthcare [1][2]. Group 1: AI in Healthcare - The pilot program in Utah, powered by Doctronic, enables AI to refill commonly prescribed medications for chronic conditions, aiming to save patients time and money, especially in rural areas with physician shortages [2]. - The initiative reflects a broader trend in healthcare where AI is increasingly trusted to automate repetitive, high-volume decisions, allowing human experts to focus on more complex tasks [3]. Group 2: Molecule.ai Platform - Shuttle Pharma's Molecule.ai platform aims to minimize inefficiencies in drug development by applying AI to predict molecular properties, model drug-target interactions, and prioritize compounds, potentially reducing the time required for manual experimentation from months to days at a lower cost [4][11]. - The platform is designed to automate resource-intensive steps in drug discovery, similar to how Utah's AI refill system automates routine prescribing decisions, thereby enabling scientists to concentrate on innovative breakthroughs [5]. Group 3: Economic Impact - The healthcare and biopharmaceutical industries face rising costs, limited human resources, and increasing demand, and AI is seen as a pathway to sustainability [7]. - AI can reduce the time to identify viable drug candidates, lower the costs associated with failed experiments, and decrease the human labor spent on repetitive tasks [8]. Group 4: Safety and Oversight - Concerns regarding AI's potential to overlook critical warning signs highlight the necessity for AI systems to be designed for accountability and safety, which is addressed by the Molecule.ai platform through features like uncertainty quantification and human-in-the-loop workflows [9][6]. - The regulatory framework in Utah serves as a model for ensuring that AI operates within defined boundaries, escalating complex cases to human oversight [6]. Group 5: Future Outlook - Results from Utah's AI prescription pilot are expected to influence future state and federal AI policies, potentially establishing a national model for AI regulation in healthcare [12]. - The vision for Shuttle Pharma's Molecule.ai platform is to create AI that accelerates drug discovery, reduces costs, and delivers better therapies to patients in a safe and responsible manner [13].

As filed with the Securities and Exchange Commission on December 11, 2025 Registration No. 333-291628 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 (Amendment No. 1) REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SHUTTLE PHARMACEUTICALS HOLDINGS, INC. (Exact name of registrant as specified in its charter) David E. Danovitch, Esq. Aaron M. Schleicher, Esq. Sullivan & Worcester LLP 1251 Avenue of the Americas, 19 Floor New York, NY 10020 (212) 660-3060 From time to ...

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Core Viewpoint - Shuttle Pharmaceuticals Holdings, Inc. has successfully completed the acquisition of Molecule.ai, enhancing its technological capabilities in drug discovery and development [1][2][4]. Acquisition Details - The acquisition involved the purchase of substantially all assets and liabilities of Molecule.ai for a total price of $8 million, which includes an initial payment of $3 million and an additional contingent payment of $2 million based on performance milestones [2][3]. - The remaining purchase price will be a combination of cash and Shuttle common stock, to be determined by Molecule at its discretion and delivered over time [2]. Strategic Importance - This acquisition is seen as a strategic milestone for Shuttle Pharmaceuticals, aimed at advancing precision radiotherapy solutions and enhancing its drug discovery pipeline through Molecule.ai's AI platform [4]. - The integration of Molecule.ai's technology is expected to accelerate molecular innovation and improve efficiency in drug development processes [4]. Company Background - Shuttle Pharmaceuticals is a clinical-stage pharmaceutical company focused on developing novel drugs that enhance the efficacy of cancer therapy, particularly in sensitizing cancer cells to radiation [5].